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Items: 1 to 20 of 109


Gene Transfer of Calcium-Binding Proteins into Adult Cardiac Myocytes.

Thompson BR, Cohen H, Angulski ABB, Metzger JM.

Methods Mol Biol. 2019;1929:187-205. doi: 10.1007/978-1-4939-9030-6_12.


Exacerbation of dystrophic cardiomyopathy by phospholamban deficiency mediated chronically increased cardiac Ca2+ cycling in vivo.

Law ML, Prins KW, Olander ME, Metzger JM.

Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1544-H1552. doi: 10.1152/ajpheart.00341.2018. Epub 2018 Aug 17.


TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility.

Vetter AD, Houang EM, Sell JJ, Thompson BR, Sham YY, Metzger JM.

Biophys J. 2018 Apr 10;114(7):1646-1656. doi: 10.1016/j.bpj.2018.02.015.


Investigation of human iPSC-derived cardiac myocyte functional maturation by single cell traction force microscopy.

Wheelwright M, Win Z, Mikkila JL, Amen KY, Alford PW, Metzger JM.

PLoS One. 2018 Apr 4;13(4):e0194909. doi: 10.1371/journal.pone.0194909. eCollection 2018.


Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension.

Prins KW, Tian L, Wu D, Thenappan T, Metzger JM, Archer SL.

J Am Heart Assoc. 2017 May 31;6(6). pii: e006195. doi: 10.1161/JAHA.117.006195.


Molecular inotropy mediated by cardiac miR-based PDE4D/PRKAR1α/phosphoprotein signaling.

Bedada FB, Martindale JJ, Arden E, Metzger JM.

Sci Rep. 2016 Nov 11;6:36803. doi: 10.1038/srep36803.


Intracoronary Poloxamer 188 Prevents Reperfusion Injury in a Porcine Model of ST-Segment Elevation Myocardial Infarction.

Bartos JA, Matsuura TR, Tsangaris A, Olson M, McKnite SH, Rees JN, Haman K, Shekar KC, Riess ML, Bates FS, Metzger JM, Yannopoulos D.

JACC Basic Transl Sci. 2016 Jun;1(4):224-234.


Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice.

Prins KW, Asp ML, Zhang H, Wang W, Metzger JM.

JACC Basic Transl Sci. 2016 Apr;1(3):122-130. Epub 2016 Apr 18.


The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.

Hampton C, Zhou X, Priest BT, Pai LY, Felix JP, Thomas-Fowlkes B, Liu J, Kohler M, Xiao J, Corona A, Price O, Gill C, Shah K, Rasa C, Tong V, Owens K, Ormes J, Tang H, Roy S, Sullivan KA, Metzger JM, Alonso-Galicia M, Kaczorowski GJ, Pasternak A, Garcia ML.

J Pharmacol Exp Ther. 2016 Oct;359(1):194-206. doi: 10.1124/jpet.116.235150. Epub 2016 Jul 18.


Sarcomere neutralization in inherited cardiomyopathy: small-molecule proof-of-concept to correct hyper-Ca2+-sensitive myofilaments.

Thompson BR, Martindale J, Metzger JM.

Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H36-43. doi: 10.1152/ajpheart.00981.2015. Epub 2016 May 13.


Effects of Modified Parvalbumin EF-Hand Motifs on Cardiac Myocyte Contractile Function.

Asp ML, Sjaastad FV, Siddiqui JK, Davis JP, Metzger JM.

Biophys J. 2016 May 10;110(9):2094-105. doi: 10.1016/j.bpj.2016.03.037.


A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.

Davis J, Davis LC, Correll RN, Makarewich CA, Schwanekamp JA, Moussavi-Harami F, Wang D, York AJ, Wu H, Houser SR, Seidman CE, Seidman JG, Regnier M, Metzger JM, Wu JC, Molkentin JD.

Cell. 2016 May 19;165(5):1147-1159. doi: 10.1016/j.cell.2016.04.002. Epub 2016 Apr 21.


Standard Operating Procedures (SOPs) for Evaluating the Heart in Preclinical Studies of Duchenne Muscular Dystrophy.

Duan D, Rafael-Fortney JA, Blain A, Kass DA, McNally EM, Metzger JM, Spurney CF, Kinnett K.

J Cardiovasc Transl Res. 2016 Feb;9(1):85-6. doi: 10.1007/s12265-015-9669-6. Epub 2015 Dec 30.


Membrane-stabilizing copolymers confer marked protection to dystrophic skeletal muscle in vivo.

Houang EM, Haman KJ, Filareto A, Perlingeiro RC, Bates FS, Lowe DA, Metzger JM.

Mol Ther Methods Clin Dev. 2015 Nov 11;2:15042. doi: 10.1038/mtm.2015.42. eCollection 2015.


Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes.

Bedada FB, Wheelwright M, Metzger JM.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1829-38. doi: 10.1016/j.bbamcr.2015.11.005. Epub 2015 Nov 11. Review.


Early Detection of Myocardial Bioenergetic Deficits: A 9.4 Tesla Complete Non Invasive 31P MR Spectroscopy Study in Mice with Muscular Dystrophy.

Cui W, Jang A, Zhang P, Thompson B, Townsend D, Metzger JM, Zhang J.

PLoS One. 2015 Aug 11;10(8):e0135000. doi: 10.1371/journal.pone.0135000. eCollection 2015.


Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A-mediated C-terminal dystrophin cleavage fragment.

Barnabei MS, Sjaastad FV, Townsend D, Bedada FB, Metzger JM.

Sci Transl Med. 2015 Jul 1;7(294):294ra106. doi: 10.1126/scitranslmed.aaa4804.


Myocardial performance and adaptive energy pathways in a torpid mammalian hibernator.

Heinis FI, Vermillion KL, Andrews MT, Metzger JM.

Am J Physiol Regul Integr Comp Physiol. 2015 Aug 15;309(4):R368-77. doi: 10.1152/ajpregu.00365.2014. Epub 2015 May 27.


Contemporary cardiac issues in Duchenne muscular dystrophy. Working Group of the National Heart, Lung, and Blood Institute in collaboration with Parent Project Muscular Dystrophy.

McNally EM, Kaltman JR, Benson DW, Canter CE, Cripe LH, Duan D, Finder JD, Groh WJ, Hoffman EP, Judge DP, Kertesz N, Kinnett K, Kirsch R, Metzger JM, Pearson GD, Rafael-Fortney JA, Raman SV, Spurney CF, Targum SL, Wagner KR, Markham LW; Working Group of the National Heart, Lung, and Blood Institute; Parent Project Muscular Dystrophy.

Circulation. 2015 May 5;131(18):1590-8. doi: 10.1161/CIRCULATIONAHA.114.015151. No abstract available. Erratum in: Circulation. 2015 Jun 23;131(25):e539. Groh, William J [added].


Bundled postconditioning therapies improve hemodynamics and neurologic recovery after 17 min of untreated cardiac arrest.

Bartos JA, Matsuura TR, Sarraf M, Youngquist ST, McKnite SH, Rees JN, Sloper DT, Bates FS, Segal N, Debaty G, Lurie KG, Neumar RW, Metzger JM, Riess ML, Yannopoulos D.

Resuscitation. 2015 Feb;87:7-13. doi: 10.1016/j.resuscitation.2014.10.019. Epub 2014 Nov 20.

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