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Items: 1 to 20 of 44

1.

Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans.

Cruces-Sande M, Vila-Bedmar R, Arcones AC, González-Rodríguez Á, Rada P, Gutiérrez-de-Juan V, Vargas-Castrillón J, Iruzubieta P, Sánchez-González C, Formentini L, Crespo J, García-Monzón C, Martínez-Chantar ML, Valverde ÁM, Mayor F Jr, Murga C.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep 24;1864(12):3655-3667. doi: 10.1016/j.bbadis.2018.09.027. [Epub ahead of print]

PMID:
30261289
2.

Phosphorylation of p38 by GRK2 at the Docking Groove Unveils a Novel Mechanism for Inactivating p38MAPK.

Peregrin S, Jurado-Pueyo M, Campos PM, Sanz-Moreno V, Ruiz-Gomez A, Crespo P, Mayor F Jr, Murga C.

Curr Biol. 2018 Aug 6;28(15):2513. doi: 10.1016/j.cub.2018.07.033. No abstract available.

PMID:
30086307
3.

G protein-coupled receptor kinase 2 (GRK2) as an integrative signalling node in the regulation of cardiovascular function and metabolic homeostasis.

Mayor F Jr, Cruces-Sande M, Arcones AC, Vila-Bedmar R, Briones AM, Salaices M, Murga C.

Cell Signal. 2018 Jan;41:25-32. doi: 10.1016/j.cellsig.2017.04.002. Epub 2017 Apr 4. Review.

PMID:
28389415
4.

Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels.

Lucas E, Vila-Bedmar R, Arcones AC, Cruces-Sande M, Cachofeiro V, Mayor F Jr, Murga C.

Cardiovasc Diabetol. 2016 Nov 10;15(1):155.

5.

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.

Singhmar P, Huo X, Eijkelkamp N, Berciano SR, Baameur F, Mei FC, Zhu Y, Cheng X, Hawke D, Mayor F Jr, Murga C, Heijnen CJ, Kavelaars A.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3036-41. doi: 10.1073/pnas.1516036113. Epub 2016 Feb 29.

6.

Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2.

Lucas E, Cruces-Sande M, Briones AM, Salaices M, Mayor F Jr, Murga C, Vila-Bedmar R.

Arch Physiol Biochem. 2015;121(5):163-77. doi: 10.3109/13813455.2015.1107589. Epub 2015 Dec 7. Review.

7.

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.

Vila-Bedmar R, Cruces-Sande M, Lucas E, Willemen HL, Heijnen CJ, Kavelaars A, Mayor F Jr, Murga C.

Sci Signal. 2015 Jul 21;8(386):ra73. doi: 10.1126/scisignal.aaa4374.

8.

Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns.

Lucas E, Jurado-Pueyo M, Fortuño MA, Fernández-Veledo S, Vila-Bedmar R, Jiménez-Borreguero LJ, Lazcano JJ, Gao E, Gómez-Ambrosi J, Frühbeck G, Koch WJ, Díez J, Mayor F Jr, Murga C.

Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2448-56. doi: 10.1016/j.bbadis.2014.09.004. Epub 2014 Sep 18.

9.

Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2.

Garcia-Guerra L, Vila-Bedmar R, Carrasco-Rando M, Cruces-Sande M, Martín M, Ruiz-Gómez A, Ruiz-Gómez M, Lorenzo M, Fernández-Veledo S, Mayor F Jr, Murga C, Nieto-Vázquez I.

J Mol Cell Biol. 2014 Aug;6(4):299-311. doi: 10.1093/jmcb/mju025. Epub 2014 Jun 13.

10.

A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia.

Willemen HL, Campos PM, Lucas E, Morreale A, Gil-Redondo R, Agut J, González FV, Ramos P, Heijnen C, Mayor F Jr, Kavelaars A, Murga C.

Biochem J. 2014 May 1;459(3):427-39. doi: 10.1042/BJ20130172.

11.

Increased nitric oxide bioavailability in adult GRK2 hemizygous mice protects against angiotensin II-induced hypertension.

Avendaño MS, Lucas E, Jurado-Pueyo M, Martínez-Revelles S, Vila-Bedmar R, Mayor F Jr, Salaices M, Briones AM, Murga C.

Hypertension. 2014 Feb;63(2):369-75. doi: 10.1161/HYPERTENSIONAHA.113.01991. Epub 2013 Nov 4.

PMID:
24191280
12.

Roles of GRK2 in cell signaling beyond GPCR desensitization: GRK2-HDAC6 interaction modulates cell spreading and motility.

Penela P, Lafarga V, Tapia O, Rivas V, Nogués L, Lucas E, Vila-Bedmar R, Murga C, Mayor F Jr.

Sci Signal. 2012 May 15;5(224):pt3. doi: 10.1126/scisignal.2003098.

PMID:
22589388
13.

GRK2 contribution to the regulation of energy expenditure and brown fat function.

Vila-Bedmar R, Garcia-Guerra L, Nieto-Vazquez I, Mayor F Jr, Lorenzo M, Murga C, Fernández-Veledo S.

FASEB J. 2012 Aug;26(8):3503-14. doi: 10.1096/fj.11-202267. Epub 2012 Apr 19.

PMID:
22516294
14.

The origin of behavioral bursts in decision-making circuitry.

Sorribes A, Armendariz BG, Lopez-Pigozzi D, Murga C, de Polavieja GG.

PLoS Comput Biol. 2011 Jun;7(6):e1002075. doi: 10.1371/journal.pcbi.1002075. Epub 2011 Jun 23.

15.

G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance.

Mayor F Jr, Lucas E, Jurado-Pueyo M, Garcia-Guerra L, Nieto-Vazquez I, Vila-Bedmar R, Fernández-Veledo S, Murga C.

Arch Physiol Biochem. 2011 Jul;117(3):125-30. doi: 10.3109/13813455.2011.584693. Epub 2011 May 26. Review.

PMID:
21615207
16.

Receptors, signaling networks, and disease.

Cuesta N, Martín-Cófreces NB, Murga C, van Santen HM.

Sci Signal. 2011 Feb 22;4(161):mr3. doi: 10.1126/scisignal.2001687.

PMID:
21343616
17.

Aural myiasis in an infant.

Casanova-Roman M, Sanchez-Legaza E, Sanchez-Porto A, Murga C.

Infez Med. 2010 Sep;18(3):175-6.

18.

G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity.

Garcia-Guerra L, Nieto-Vazquez I, Vila-Bedmar R, Jurado-Pueyo M, Zalba G, Díez J, Murga C, Fernández-Veledo S, Mayor F Jr, Lorenzo M.

Diabetes. 2010 Oct;59(10):2407-17. doi: 10.2337/db10-0771. Epub 2010 Jul 13.

19.

The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets.

Penela P, Murga C, Ribas C, Lafarga V, Mayor F Jr.

Br J Pharmacol. 2010 Jun;160(4):821-32. doi: 10.1111/j.1476-5381.2010.00727.x. Review.

20.

GRK6, a gatekeeper of visceral hyperalgesia.

Murga C, Mayor F Jr.

Brain Behav Immun. 2009 Jan;23(1):16-7. doi: 10.1016/j.bbi.2008.10.002. Epub 2008 Oct 17. No abstract available.

PMID:
18977289

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