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Items: 1 to 20 of 76

1.

Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish.

Marín-Juez R, Jong-Raadsen S, Yang S, Spaink HP.

J Endocrinol. 2014 Aug;222(2):229-41. doi: 10.1530/JOE-14-0178. Epub 2014 Jun 5.

PMID:
24904114
2.

Deficiency in hematopoietic phosphatase ptpn6/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos.

Kanwal Z, Zakrzewska A, den Hertog J, Spaink HP, Schaaf MJ, Meijer AH.

J Immunol. 2013 Feb 15;190(4):1631-45. doi: 10.4049/jimmunol.1200551. Epub 2013 Jan 18.

3.

Hepatocyte-specific Ptpn6 deletion protects from obesity-linked hepatic insulin resistance.

Xu E, Charbonneau A, Rolland Y, Bellmann K, Pao L, Siminovitch KA, Neel BG, Beauchemin N, Marette A.

Diabetes. 2012 Aug;61(8):1949-58. doi: 10.2337/db11-1502. Epub 2012 Jun 14.

4.

Etiology of the metabolic syndrome: potential role of insulin resistance, leptin resistance, and other players.

Zimmet P, Boyko EJ, Collier GR, de Courten M.

Ann N Y Acad Sci. 1999 Nov 18;892:25-44. Review.

PMID:
10842650
5.

Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARγ.

Xu E, Forest MP, Schwab M, Avramoglu RK, St-Amand E, Caron AZ, Bellmann K, Shum M, Voisin G, Paquet M, Montoudis A, Lévy E, Siminovitch KA, Neel BG, Beauchemin N, Marette A.

Hepatology. 2014 May;59(5):1803-15. doi: 10.1002/hep.26957. Epub 2014 Apr 1.

PMID:
24327268
6.

Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: a potential mechanism for hyperinsulinaemia-associated leptin resistance.

Kellerer M, Lammers R, Fritsche A, Strack V, Machicao F, Borboni P, Ullrich A, Häring HU.

Diabetologia. 2001 Sep;44(9):1125-32.

PMID:
11596667
7.

Insulin resistance, hyperinsulinemia, and hypertension: causes, consequences, or merely correlations?

Hall JE, Brands MW, Zappe DH, Alonso Galicia M.

Proc Soc Exp Biol Med. 1995 Apr;208(4):317-29. Review.

PMID:
7700881
8.

Insulin resistance and hyperinsulinemia in hypertension.

Weidmann P, Böhlen L, de Courten M.

J Hypertens Suppl. 1995 Aug;13(2):S65-72. Review.

PMID:
8576790
9.

Disease model: hyperinsulinemia and insulin resistance. Part A-targeted disruption of insulin signaling or glucose transport.

Sone H, Suzuki H, Takahashi A, Yamada N.

Trends Mol Med. 2001 Jul;7(7):320-2. Review.

PMID:
11425641
10.

GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish.

Jiménez-Amilburu V, Jong-Raadsen S, Bakkers J, Spaink HP, Marín-Juez R.

J Endocrinol. 2015 Jan;224(1):1-15. doi: 10.1530/JOE-14-0539. Epub 2014 Oct 17.

PMID:
25326603
11.

Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse?

Shanik MH, Xu Y, Skrha J, Dankner R, Zick Y, Roth J.

Diabetes Care. 2008 Feb;31 Suppl 2:S262-8. doi: 10.2337/dc08-s264. Review.

PMID:
18227495
12.

Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain.

Catalano KJ, Maddux BA, Szary J, Youngren JF, Goldfine ID, Schaufele F.

PLoS One. 2014 Sep 26;9(9):e108693. doi: 10.1371/journal.pone.0108693. eCollection 2014.

13.

Insulin resistance, hyperinsulinemia, and coronary artery disease: a complex metabolic web.

DeFronzo RA.

J Cardiovasc Pharmacol. 1992;20 Suppl 11:S1-16. Review.

PMID:
1284137
14.

Modulators of insulin action and their role in insulin resistance.

Pirola L, Johnston AM, Van Obberghen E.

Int J Obes Relat Metab Disord. 2003 Dec;27 Suppl 3:S61-4. Review.

PMID:
14704748
15.

Hemorheological aspects of the metabolic syndrome: markers of insulin resistance, obesity or hyperinsulinemia?

Brun JF, Aloulou I, Varlet-Marie E.

Clin Hemorheol Microcirc. 2004;30(3-4):203-9.

PMID:
15258344
16.

Hyperinsulinemia superimposed on insulin resistance does not elevate blood pressure.

Verma S, Leung YM, Yao L, Battell M, Dumont AS, McNeill JH.

Am J Hypertens. 2001 May;14(5 Pt 1):429-32.

PMID:
11368463
17.

Molecular mechanisms of insulin resistance that impact cardiovascular biology.

Wang CC, Goalstone ML, Draznin B.

Diabetes. 2004 Nov;53(11):2735-40. Review.

18.

Insulin resistance, hyperinsulinemia, and renal injury: mechanisms and implications.

Sarafidis PA, Ruilope LM.

Am J Nephrol. 2006;26(3):232-44. Epub 2006 May 29. Review.

PMID:
16733348
19.

Insulin resistance, the insulin resistance syndrome, and cardiovascular disease.

Reaven GM.

Panminerva Med. 2005 Dec;47(4):201-10. Review.

PMID:
16489319
20.

Central obesity in rhesus monkeys: association with hyperinsulinemia, insulin resistance and hypertriglyceridemia?

Bodkin NL, Hannah JS, Ortmeyer HK, Hansen BC.

Int J Obes Relat Metab Disord. 1993 Jan;17(1):53-61.

PMID:
8383642

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