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Items: 1 to 20 of 352

1.

TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro.

Larsson J, Blank U, Helgadottir H, Björnsson JM, Ehinger M, Goumans MJ, Fan X, Levéen P, Karlsson S.

Blood. 2003 Nov 1;102(9):3129-35. Epub 2003 Jul 3.

2.

Quiescence of hematopoietic stem cells and maintenance of the stem cell pool is not dependent on TGF-beta signaling in vivo.

Larsson J, Blank U, Klintman J, Magnusson M, Karlsson S.

Exp Hematol. 2005 May;33(5):592-6.

PMID:
15850837
3.
4.

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable.

Levéen P, Larsson J, Ehinger M, Cilio CM, Sundler M, Sjöstrand LJ, Holmdahl R, Karlsson S.

Blood. 2002 Jul 15;100(2):560-8.

5.

TGF-beta type II receptor-deficient thymocytes develop normally but demonstrate increased CD8+ proliferation in vivo.

Levéen P, Carlsén M, Makowska A, Oddsson S, Larsson J, Goumans MJ, Cilio CM, Karlsson S.

Blood. 2005 Dec 15;106(13):4234-40. Epub 2005 Aug 30.

6.

Release from quiescence of primitive human hematopoietic stem/progenitor cells by blocking their cell-surface TGF-beta type II receptor in a short-term in vitro assay.

Fortunel N, Hatzfeld J, Kisselev S, Monier MN, Ducos K, Cardoso A, Batard P, Hatzfeld A.

Stem Cells. 2000;18(2):102-11.

7.

The role of Smad signaling in hematopoiesis.

Larsson J, Karlsson S.

Oncogene. 2005 Aug 29;24(37):5676-92. Review.

PMID:
16123801
8.

Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function.

Schniewind B, Groth S, Sebens Müerköster S, Sipos B, Schäfer H, Kalthoff H, Fändrich F, Ungefroren H.

Oncogene. 2007 Jul 19;26(33):4850-62. Epub 2007 Feb 12.

PMID:
17297450
9.

Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice.

Oe S, Lemmer ER, Conner EA, Factor VM, Levéen P, Larsson J, Karlsson S, Thorgeirsson SS.

Hepatology. 2004 Nov;40(5):1098-105.

PMID:
15389868
10.

Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation.

Itoh F, Itoh S, Carvalho RL, Adachi T, Ema M, Goumans MJ, Larsson J, Karlsson S, Takahashi S, Mummery CL, Dijke PT, Kato M.

Lab Invest. 2009 Jul;89(7):800-10. doi: 10.1038/labinvest.2009.37. Epub 2009 Apr 27.

11.

Smad5 is dispensable for adult murine hematopoiesis.

Singbrant S, Moody JL, Blank U, Karlsson G, Umans L, Zwijsen A, Karlsson S.

Blood. 2006 Dec 1;108(12):3707-12. Epub 2006 Aug 8.

12.

Complex and context dependent regulation of hematopoiesis by TGF-beta superfamily signaling.

Söderberg SS, Karlsson G, Karlsson S.

Ann N Y Acad Sci. 2009 Sep;1176:55-69. doi: 10.1111/j.1749-6632.2009.04569.x. Review.

PMID:
19796233
13.
14.

Control of hematopoietic stem/progenitor cell fate by transforming growth factor-beta.

Fortunel NO, Hatzfeld JA, Monier MN, Hatzfeld A.

Oncol Res. 2003;13(6-10):445-53.

PMID:
12725536
15.

Transforming growth factor-beta- and Activin-Smad signaling pathways are activated at distinct maturation stages of the thymopoeisis.

Rosendahl A, Speletas M, Leandersson K, Ivars F, Sideras P.

Int Immunol. 2003 Dec;15(12):1401-14.

PMID:
14645149
16.

Transient disruption of autocrine TGF-beta signaling leads to enhanced survival and proliferation potential in single primitive human hemopoietic progenitor cells.

Fan X, Valdimarsdottir G, Larsson J, Brun A, Magnusson M, Jacobsen SE, ten Dijke P, Karlsson S.

J Immunol. 2002 Jan 15;168(2):755-62.

17.

Mouse embryonic stem cells with aberrant transforming growth factor beta signalling exhibit impaired differentiation in vitro and in vivo.

Goumans MJ, Ward-van Oostwaard D, Wianny F, Savatier P, Zwijsen A, Mummery C.

Differentiation. 1998 Jul;63(3):101-13.

PMID:
9697304
18.

RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation.

Purton LE, Dworkin S, Olsen GH, Walkley CR, Fabb SA, Collins SJ, Chambon P.

J Exp Med. 2006 May 15;203(5):1283-93. Epub 2006 May 8. Erratum in: J Exp Med. 2006 Jun 12;203(6):1615.

19.

Gene expression profiling demonstrates that TGF-beta1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-beta signaling.

Karlsson G, Liu Y, Larsson J, Goumans MJ, Lee JS, Thorgeirsson SS, Ringnér M, Karlsson S.

Physiol Genomics. 2005 May 11;21(3):396-403. Epub 2005 Mar 15.

PMID:
15769904
20.

Suppression of tumor metastasis by blockade of transforming growth factor beta signaling in bone marrow cells through a retroviral-mediated gene therapy in mice.

Shah AH, Tabayoyong WB, Kundu SD, Kim SJ, Van Parijs L, Liu VC, Kwon E, Greenberg NM, Lee C.

Cancer Res. 2002 Dec 15;62(24):7135-8.

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