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Items: 1 to 20 of 100

1.

Synthesis, biological evaluation and molecular docking studies of new amides of 4-chlorothiocolchicine as anticancer agents.

Klejborowska G, Urbaniak A, Maj E, Preto J, Moshari M, Wietrzyk J, Tuszynski JA, Chambers TC, Huczyński A.

Bioorg Chem. 2020 Apr;97:103664. doi: 10.1016/j.bioorg.2020.103664. Epub 2020 Feb 13.

2.

Synthesis, biological evaluation and molecular docking studies of new amides of 4-bromothiocolchicine as anticancer agents.

Klejborowska G, Urbaniak A, Preto J, Maj E, Moshari M, Wietrzyk J, Tuszynski JA, Chambers TC, Huczyński A.

Bioorg Med Chem. 2019 Dec 1;27(23):115144. doi: 10.1016/j.bmc.2019.115144. Epub 2019 Oct 8.

3.

Synthesis, antiproliferative activity, and molecular docking studies of 4-chlorothiocolchicine analogues.

Klejborowska G, Moshari M, Maj E, Majcher U, Preto J, Wietrzyk J, Tuszynski JA, Huczyński A.

Chem Biol Drug Des. 2020 Jan;95(1):182-191. doi: 10.1111/cbdd.13618. Epub 2019 Sep 20.

PMID:
31483093
4.

Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents.

Majcher U, Klejborowska G, Kaik M, Maj E, Wietrzyk J, Moshari M, Preto J, Tuszynski JA, Huczyński A.

Cells. 2018 Nov 19;7(11). pii: E216. doi: 10.3390/cells7110216.

5.

Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes.

Majcher U, Urbaniak A, Maj E, Moshari M, Delgado M, Wietrzyk J, Bartl F, Chambers TC, Tuszynski JA, Huczyński A.

Bioorg Chem. 2018 Dec;81:553-566. doi: 10.1016/j.bioorg.2018.09.004. Epub 2018 Sep 12.

PMID:
30248507
6.

Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives.

Majcher U, Klejborowska G, Moshari M, Maj E, Wietrzyk J, Bartl F, Tuszynski JA, Huczyński A.

Cells. 2018 Nov 1;7(11). pii: E192. doi: 10.3390/cells7110192.

7.

Synthesis and biological evaluation of novel benzo[c]acridine-diones as potential anticancer agents and tubulin polymerization inhibitors.

Behbahani FS, Tabeshpour J, Mirzaei S, Golmakaniyoon S, Tayarani-Najaran Z, Ghasemi A, Ghodsi R.

Arch Pharm (Weinheim). 2019 Jun;352(6):e1800307. doi: 10.1002/ardp.201800307. Epub 2019 Apr 23.

PMID:
31012156
8.

Design, synthesis and molecular modeling of new 4-phenylcoumarin derivatives as tubulin polymerization inhibitors targeting MCF-7 breast cancer cells.

Batran RZ, Kassem AF, Abbas EMH, Elseginy SA, Mounier MM.

Bioorg Med Chem. 2018 Jul 23;26(12):3474-3490. doi: 10.1016/j.bmc.2018.05.022. Epub 2018 May 16.

PMID:
29793751
9.

Colchicine-like β-acetamidoketones as inhibitors of microtubule polymerization: Design, synthesis and biological evaluation of in vitro anticancer activity.

Karimikia E, Behravan J, Zarghi A, Ghandadi M, Omid Malayeri S, Ghodsi R.

Iran J Basic Med Sci. 2019 Oct;22(10):1138-1146. doi: 10.22038/ijbms.2019.34760.8242.

10.

Design, Synthesis, In Vitro Anti-cancer Activity, ADMET Profile and Molecular Docking of Novel Triazolo[3,4-a]phthalazine Derivatives Targeting VEGFR-2 Enzyme.

El-Helby AA, Sakr H, Ayyad RRA, El-Adl K, Ali MM, Khedr F.

Anticancer Agents Med Chem. 2018;18(8):1184-1196. doi: 10.2174/1871520618666180412123833.

PMID:
29651967
11.
12.

Synthesis and biological evaluation of pyrimidine bridged combretastatin derivatives as potential anticancer agents and mechanistic studies.

Kumar B, Sharma P, Gupta VP, Khullar M, Singh S, Dogra N, Kumar V.

Bioorg Chem. 2018 Aug;78:130-140. doi: 10.1016/j.bioorg.2018.02.027. Epub 2018 Feb 28.

PMID:
29554587
13.

Design, synthesis, biological evaluation and molecular docking studies of new chalcone derivatives containing diaryl ether moiety as potential anticancer agents and tubulin polymerization inhibitors.

Wang G, Liu W, Gong Z, Huang Y, Li Y, Peng Z.

Bioorg Chem. 2020 Jan;95:103565. doi: 10.1016/j.bioorg.2019.103565. Epub 2019 Dec 31.

PMID:
31927336
14.

Synthesis, antiproliferative activity and molecular docking of Colchicine derivatives.

Huczyński A, Majcher U, Maj E, Wietrzyk J, Janczak J, Moshari M, Tuszynski JA, Bartl F.

Bioorg Chem. 2016 Feb;64:103-12. doi: 10.1016/j.bioorg.2016.01.002. Epub 2016 Jan 12.

PMID:
26794327
15.

Synthesis, biological evaluation, and molecular docking studies of cinnamic acyl 1,3,4-thiadiazole amide derivatives as novel antitubulin agents.

Yang XH, Wen Q, Zhao TT, Sun J, Li X, Xing M, Lu X, Zhu HL.

Bioorg Med Chem. 2012 Feb 1;20(3):1181-7. doi: 10.1016/j.bmc.2011.12.057. Epub 2012 Jan 5.

PMID:
22261027
16.

Synthesis, biological evaluation and molecular docking studies of aminochalcone derivatives as potential anticancer agents by targeting tubulin colchicine binding site.

Wang G, Peng Z, Zhang J, Qiu J, Xie Z, Gong Z.

Bioorg Chem. 2018 Aug;78:332-340. doi: 10.1016/j.bioorg.2018.03.028. Epub 2018 Apr 3.

PMID:
29627654
17.

In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand.

Pallante L, Rocca A, Klejborowska G, Huczynski A, Grasso G, Tuszynski JA, Deriu MA.

Front Chem. 2020 Feb 21;8:108. doi: 10.3389/fchem.2020.00108. eCollection 2020.

18.

Synthesis and biological evaluation of indole-2-carbohydrazides and thiazolidinyl-indole-2-carboxamides as potent tubulin polymerization inhibitors.

Kazan F, Yagci ZB, Bai R, Ozkirimli E, Hamel E, Ozkirimli S.

Comput Biol Chem. 2019 Jun;80:512-523. doi: 10.1016/j.compbiolchem.2019.05.002. Epub 2019 May 11.

PMID:
31185422
19.

Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.

Liu YN, Wang JJ, Ji YT, Zhao GD, Tang LQ, Zhang CM, Guo XL, Liu ZP.

J Med Chem. 2016 Jun 9;59(11):5341-55. doi: 10.1021/acs.jmedchem.6b00071. Epub 2016 May 20.

PMID:
27172319
20.

Synthesis, biological evaluation, and molecular docking investigation of 3-amidoindoles as potent tubulin polymerization inhibitors.

Chen P, Zhuang YX, Diao PC, Yang F, Wu SY, Lv L, You WW, Zhao PL.

Eur J Med Chem. 2019 Jan 15;162:525-533. doi: 10.1016/j.ejmech.2018.11.038. Epub 2018 Nov 17.

PMID:
30472600

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