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Items: 1 to 20 of 101

1.

A Novel Prodrug Approach for Central Nervous System-Selective Estrogen Therapy.

Prokai-Tatrai K, Prokai L.

Molecules. 2019 Nov 19;24(22). pii: E4197. doi: 10.3390/molecules24224197. Review.

2.

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders.

Prokai L, Nguyen V, Szarka S, Garg P, Sabnis G, Bimonte-Nelson HA, McLaughlin KJ, Talboom JS, Conrad CD, Shughrue PJ, Gould TD, Brodie A, Merchenthaler I, Koulen P, Prokai-Tatrai K.

Sci Transl Med. 2015 Jul 22;7(297):297ra113. doi: 10.1126/scitranslmed.aab1290.

3.

10β,17α-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug Preferentially Producing 17α-Estradiol in the Brain for Targeted Neurotherapy.

Prokai-Tatrai K, Nguyen V, Prokai L.

ACS Chem Neurosci. 2018 Nov 21;9(11):2528-2533. doi: 10.1021/acschemneuro.8b00184. Epub 2018 Jun 5.

4.

Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery.

Merchenthaler I, Lane M, Sabnis G, Brodie A, Nguyen V, Prokai L, Prokai-Tatrai K.

Sci Rep. 2016 Aug 1;6:30721. doi: 10.1038/srep30721.

5.

A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease.

Tschiffely AE, Schuh RA, Prokai-Tatrai K, Prokai L, Ottinger MA.

Horm Behav. 2016 Jul;83:39-44. doi: 10.1016/j.yhbeh.2016.05.009. Epub 2016 May 19.

6.

Drugs with estrogen-like potency and brain activity: potential therapeutic application for the CNS.

Cyr M, Calon F, Morissette M, Grandbois M, Di Paolo T, Callier S.

Curr Pharm Des. 2000 Aug;6(12):1287-312. Review.

PMID:
10903393
7.

Treatment with a brain-selective prodrug of 17β-estradiol improves cognitive function in Alzheimer's disease mice by regulating klf5-NF-κB pathway.

Yan W, Wu J, Song B, Luo Q, Xu Y.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Jul;392(7):879-886. doi: 10.1007/s00210-019-01639-w. Epub 2019 Mar 16.

PMID:
30879099
8.

An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease.

Tschiffely AE, Schuh RA, Prokai-Tatrai K, Ottinger MA, Prokai L.

Horm Behav. 2018 Feb;98:16-21. doi: 10.1016/j.yhbeh.2017.11.015. Epub 2017 Dec 22.

9.

From the 90's to now: A brief historical perspective on more than two decades of estrogen neuroprotection.

Engler-Chiurazzi EB, Singh M, Simpkins JW.

Brain Res. 2016 Feb 15;1633:96-100. doi: 10.1016/j.brainres.2015.12.044. Epub 2015 Dec 29.

10.

Reprint of: From the 90׳s to now: A brief historical perspective on more than two decades of estrogen neuroprotection.

Engler-Chiurazzi EB, Singh M, Simpkins JW.

Brain Res. 2016 Aug 15;1645:79-82. doi: 10.1016/j.brainres.2016.06.016. Epub 2016 Jun 16. Review.

11.

Comparison of estrogen-derived ortho-quinone and para-quinol concerning induction of oxidative stress.

Rivera-Portalatin NM, Vera-Serrano JL, Prokai-Tatrai K, Prokai L.

J Steroid Biochem Mol Biol. 2007 Jun-Jul;105(1-5):71-5. Epub 2007 May 17.

12.

Tissue-selective estrogen complexes for postmenopausal women.

Mirkin S, Komm BS.

Maturitas. 2013 Nov;76(3):213-20. doi: 10.1016/j.maturitas.2013.06.003. Epub 2013 Jul 11. Review.

PMID:
23849704
13.

Emerging hormonal treatments for menopausal symptoms.

Genazzani AR, Komm BS, Pickar JH.

Expert Opin Emerg Drugs. 2015 Mar;20(1):31-46. doi: 10.1517/14728214.2015.986093. Epub 2015 Jan 5. Review.

PMID:
25557757
14.

Neuroprotective effects of estrogen in CNS injuries: insights from animal models.

Raghava N, Das BC, Ray SK.

Neurosci Neuroecon. 2017;6:15-29. doi: 10.2147/NAN.S105134. Epub 2017 Jul 4.

15.

Estrogen, cognition and female ageing.

Genazzani AR, Pluchino N, Luisi S, Luisi M.

Hum Reprod Update. 2007 Mar-Apr;13(2):175-87. Epub 2006 Nov 29. Review.

PMID:
17135285
17.

Practical one-pot conversion of 17beta-estradiol to 10beta-hydroxy- (p-quinol) and 10beta-chloro-17beta-hydroxyestra-1,4-dien-3-one.

Lista L, Manini P, Napolitano A, Pezzella A, d'Ischia M.

Steroids. 2006 Aug;71(8):670-3. Epub 2006 May 30.

PMID:
16730767
18.

Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection.

Prokai L, Prokai-Tatrai K, Perjesi P, Zharikova AD, Perez EJ, Liu R, Simpkins JW.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11741-6. Epub 2003 Sep 22.

19.

Estrogens and neuroprotection in retinal diseases.

Kumar DM, Simpkins JW, Agarwal N.

Mol Vis. 2008 Aug 11;14:1480-6. Review. Retraction in: Mol Vis. 2008;14:2204.

20.

Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury.

Engler-Chiurazzi EB, Brown CM, Povroznik JM, Simpkins JW.

Prog Neurobiol. 2017 Oct;157:188-211. doi: 10.1016/j.pneurobio.2015.12.008. Epub 2016 Feb 15. Review.

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