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Items: 1 to 20 of 95

1.

Synthesis, biological evaluation and molecular docking studies of new amides of 4-bromothiocolchicine as anticancer agents.

Klejborowska G, Urbaniak A, Preto J, Maj E, Moshari M, Wietrzyk J, Tuszynski JA, Chambers TC, Huczyński A.

Bioorg Med Chem. 2019 Dec 1;27(23):115144. doi: 10.1016/j.bmc.2019.115144. Epub 2019 Oct 8.

2.

Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents.

Majcher U, Klejborowska G, Kaik M, Maj E, Wietrzyk J, Moshari M, Preto J, Tuszynski JA, Huczyński A.

Cells. 2018 Nov 19;7(11). pii: E216. doi: 10.3390/cells7110216.

3.

Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives.

Majcher U, Klejborowska G, Moshari M, Maj E, Wietrzyk J, Bartl F, Tuszynski JA, Huczyński A.

Cells. 2018 Nov 1;7(11). pii: E192. doi: 10.3390/cells7110192.

4.

Synthesis, antiproliferative activity, and molecular docking studies of 4-chlorothiocolchicine analogues.

Klejborowska G, Moshari M, Maj E, Majcher U, Preto J, Wietrzyk J, Tuszynski JA, Huczyński A.

Chem Biol Drug Des. 2020 Jan;95(1):182-191. doi: 10.1111/cbdd.13618. Epub 2019 Sep 20.

PMID:
31483093
5.

Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes.

Majcher U, Urbaniak A, Maj E, Moshari M, Delgado M, Wietrzyk J, Bartl F, Chambers TC, Tuszynski JA, Huczyński A.

Bioorg Chem. 2018 Dec;81:553-566. doi: 10.1016/j.bioorg.2018.09.004. Epub 2018 Sep 12.

PMID:
30248507
6.

Design, synthesis and molecular modeling of new 4-phenylcoumarin derivatives as tubulin polymerization inhibitors targeting MCF-7 breast cancer cells.

Batran RZ, Kassem AF, Abbas EMH, Elseginy SA, Mounier MM.

Bioorg Med Chem. 2018 Jul 23;26(12):3474-3490. doi: 10.1016/j.bmc.2018.05.022. Epub 2018 May 16.

PMID:
29793751
7.

Design, Synthesis, In Vitro Anti-cancer Activity, ADMET Profile and Molecular Docking of Novel Triazolo[3,4-a]phthalazine Derivatives Targeting VEGFR-2 Enzyme.

El-Helby AA, Sakr H, Ayyad RRA, El-Adl K, Ali MM, Khedr F.

Anticancer Agents Med Chem. 2018;18(8):1184-1196. doi: 10.2174/1871520618666180412123833.

PMID:
29651967
8.

Synthesis, antiproliferative activity and molecular docking of Colchicine derivatives.

Huczyński A, Majcher U, Maj E, Wietrzyk J, Janczak J, Moshari M, Tuszynski JA, Bartl F.

Bioorg Chem. 2016 Feb;64:103-12. doi: 10.1016/j.bioorg.2016.01.002. Epub 2016 Jan 12.

PMID:
26794327
9.

Synthesis and biological evaluation of pyrimidine bridged combretastatin derivatives as potential anticancer agents and mechanistic studies.

Kumar B, Sharma P, Gupta VP, Khullar M, Singh S, Dogra N, Kumar V.

Bioorg Chem. 2018 Aug;78:130-140. doi: 10.1016/j.bioorg.2018.02.027. Epub 2018 Feb 28.

PMID:
29554587
10.
11.

Interactions of long-chain homologues of colchicine with tubulin.

Marzo-Mas A, Barbier P, Breuzard G, Allegro D, Falomir E, Murga J, Carda M, Peyrot V, Marco JA.

Eur J Med Chem. 2017 Jan 27;126:526-535. doi: 10.1016/j.ejmech.2016.11.049. Epub 2016 Nov 23.

PMID:
27915168
12.
13.

Design, Synthesis, Cytotoxic Evaluation and Molecular Docking of New Fluoroquinazolinones as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects.

Zayed MF, Ahmed S, Ihmaid S, Ahmed HEA, Rateb HS, Ibrahim SRM.

Int J Mol Sci. 2018 Jun 11;19(6). pii: E1731. doi: 10.3390/ijms19061731.

14.

Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.

Liu YN, Wang JJ, Ji YT, Zhao GD, Tang LQ, Zhang CM, Guo XL, Liu ZP.

J Med Chem. 2016 Jun 9;59(11):5341-55. doi: 10.1021/acs.jmedchem.6b00071. Epub 2016 May 20.

PMID:
27172319
15.

Stereochemical preference toward oncotarget: Design, synthesis and in vitro anticancer evaluation of diastereomeric β-lactams.

Olazarán-Santibáñez F, Bandyopadhyay D, Carranza-Rosales P, Rivera G, Balderas-Rentería I.

Oncotarget. 2017 Jun 6;8(23):37773-37782. doi: 10.18632/oncotarget.18077.

16.

Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin.

Spasevska I, Ayoub AT, Winter P, Preto J, Wong GK, Dumontet C, Tuszynski JA.

Int J Mol Sci. 2017 Aug 2;18(8). pii: E1676. doi: 10.3390/ijms18081676.

17.

Synthesis, biological evaluation and molecular docking studies of aminochalcone derivatives as potential anticancer agents by targeting tubulin colchicine binding site.

Wang G, Peng Z, Zhang J, Qiu J, Xie Z, Gong Z.

Bioorg Chem. 2018 Aug;78:332-340. doi: 10.1016/j.bioorg.2018.03.028. Epub 2018 Apr 3.

PMID:
29627654
18.

A novel microtubule depolymerizing colchicine analogue triggers apoptosis and autophagy in HCT-116 colon cancer cells.

Kumar A, Singh B, Sharma PR, Bharate SB, Saxena AK, Mondhe DM.

Cell Biochem Funct. 2016 Mar;34(2):69-81. doi: 10.1002/cbf.3166.

PMID:
26919061
19.

Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.

Li W, Shuai W, Sun H, Xu F, Bi Y, Xu J, Ma C, Yao H, Zhu Z, Xu S.

Eur J Med Chem. 2019 Feb 1;163:428-442. doi: 10.1016/j.ejmech.2018.11.070. Epub 2018 Nov 29.

PMID:
30530194
20.

Synthesis of the vitamin E amino acid esters with an enhanced anticancer activity and in silico screening for new antineoplastic drugs.

Gagic Z, Ivkovic B, Srdic-Rajic T, Vucicevic J, Nikolic K, Agbaba D.

Eur J Pharm Sci. 2016 Jun 10;88:59-69. doi: 10.1016/j.ejps.2016.04.008. Epub 2016 Apr 8.

PMID:
27063330

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