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Items: 1 to 20 of 101

1.

Polycystin-1 Inhibits Cell Proliferation through Phosphatase PP2A/B56α.

Tang Y, Yang J, Zheng W, Tang J, Chen XZ, Yang J, Wang Z.

Biomed Res Int. 2019 Sep 19;2019:2582401. doi: 10.1155/2019/2582401. eCollection 2019.

2.

Role of PKR in the Inhibition of Proliferation and Translation by Polycystin-1.

Tang Y, Shi G, Yang J, Zheng W, Tang J, Chen XZ, Yang J, Wang Z.

Biomed Res Int. 2019 Jun 23;2019:5320747. doi: 10.1155/2019/5320747. eCollection 2019.

3.

Polycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathway.

Tang Y, Wang Z, Yang J, Zheng W, Chen D, Wu G, Sandford R, Tang J, Chen XZ.

Sci Rep. 2017 Sep 13;7(1):11493. doi: 10.1038/s41598-017-11526-0.

4.

Protein phosphatase 2A is regulated by protein kinase Cα (PKCα)-dependent phosphorylation of its targeting subunit B56α at Ser41.

Kirchhefer U, Heinick A, König S, Kristensen T, Müller FU, Seidl MD, Boknik P.

J Biol Chem. 2014 Jan 3;289(1):163-76. doi: 10.1074/jbc.M113.507996. Epub 2013 Nov 13.

5.

Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation.

Li Y, Wang X, Yue P, Tao H, Ramalingam SS, Owonikoko TK, Deng X, Wang Y, Fu H, Khuri FR, Sun SY.

J Biol Chem. 2013 May 10;288(19):13215-24. doi: 10.1074/jbc.M113.463679. Epub 2013 Mar 27.

6.

B56α subunit of protein phosphatase 2A mediates retinoic acid-induced decreases in phosphorylation of endothelial nitric oxide synthase at serine 1179 and nitric oxide production in bovine aortic endothelial cells.

Park JH, Sung HY, Lee JY, Kim HJ, Ahn JH, Jo I.

Biochem Biophys Res Commun. 2013 Jan 11;430(2):476-81. doi: 10.1016/j.bbrc.2012.12.011. Epub 2012 Dec 10.

PMID:
23237802
7.

Polycystin-1 downregulation induces ERK-dependent mTOR pathway activation in a cellular model of psoriasis.

Gargalionis AN, Malakou LS, Adamopoulos C, Piperi C, Theohari I, Nokhbehsaim M, Deschner J, Kokkalis G, Korkolopoulou P, Papadavid E, Papavassiliou AG, Basdra EK.

Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3468-3476. doi: 10.1016/j.bbadis.2018.07.036. Epub 2018 Aug 2.

8.

Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells.

de Stephanis L, Bonon A, Varani K, Lanza G, Gafà R, Pinton P, Pema M, Somlo S, Boletta A, Aguiari G.

Clin Exp Nephrol. 2017 Apr;21(2):203-211. doi: 10.1007/s10157-016-1289-1. Epub 2016 Jun 9.

9.

PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells.

Ruvolo VR, Kurinna SM, Karanjeet KB, Schuster TF, Martelli AM, McCubrey JA, Ruvolo PP.

J Biol Chem. 2008 Dec 19;283(51):35474-85. doi: 10.1074/jbc.M800951200. Epub 2008 Oct 28.

10.

Steviol stabilizes polycystin 1 expression and promotes lysosomal degradation of CFTR and β-catenin proteins in renal epithelial cells.

Yuajit C, Muanprasat C, Homvisasevongsa S, Chatsudthipong V.

Biomed Pharmacother. 2017 Oct;94:820-826. doi: 10.1016/j.biopha.2017.07.165. Epub 2017 Aug 10.

PMID:
28802235
11.

Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.

Streets AJ, Wessely O, Peters DJ, Ong AC.

Hum Mol Genet. 2013 May 15;22(10):1924-39. doi: 10.1093/hmg/ddt031. Epub 2013 Feb 5.

12.

Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart.

Little SC, Curran J, Makara MA, Kline CF, Ho HT, Xu Z, Wu X, Polina I, Musa H, Meadows AM, Carnes CA, Biesiadecki BJ, Davis JP, Weisleder N, Györke S, Wehrens XH, Hund TJ, Mohler PJ.

Sci Signal. 2015 Jul 21;8(386):ra72. doi: 10.1126/scisignal.aaa5876.

13.

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease.

Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T.

Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5466-71. Epub 2006 Mar 27.

14.

A study of sirolimus and mTOR kinase inhibitor in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease.

Holditch SJ, Brown CN, Atwood DJ, Lombardi AM, Nguyen KN, Toll HW, Hopp K, Edelstein CL.

Am J Physiol Renal Physiol. 2019 Jul 1;317(1):F187-F196. doi: 10.1152/ajprenal.00051.2019. Epub 2019 May 1.

PMID:
31042058
15.

Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase.

Bielinski VA, Mumby MC.

Exp Cell Res. 2007 Aug 15;313(14):3117-26. Epub 2007 May 16.

16.

Polycystin-1 regulates STAT activity by a dual mechanism.

Talbot JJ, Shillingford JM, Vasanth S, Doerr N, Mukherjee S, Kinter MT, Watnick T, Weimbs T.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7985-90. doi: 10.1073/pnas.1103816108. Epub 2011 Apr 25.

17.

The cytoplasmic C-terminus of polycystin-1 increases cell proliferation in kidney epithelial cells through serum-activated and Ca(2+)-dependent pathway(s).

Manzati E, Aguiari G, Banzi M, Manzati M, Selvatici R, Falzarano S, Maestri I, Pinton P, Rizzuto R, del Senno L.

Exp Cell Res. 2005 Apr 1;304(2):391-406. Epub 2004 Dec 15.

PMID:
15748886
18.

Polycystin-1 protein level determines activity of the Galpha12/JNK apoptosis pathway.

Yu W, Kong T, Beaudry S, Tran M, Negoro H, Yanamadala V, Denker BM.

J Biol Chem. 2010 Apr 2;285(14):10243-51. doi: 10.1074/jbc.M109.070821. Epub 2010 Jan 27.

19.

Berberine slows cell growth in autosomal dominant polycystic kidney disease cells.

Bonon A, Mangolini A, Pinton P, Del Senno L, Aguiari G.

Biochem Biophys Res Commun. 2013 Nov 22;441(3):668-74. doi: 10.1016/j.bbrc.2013.10.076. Epub 2013 Oct 31.

PMID:
24184483
20.

Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.

Cebotaru V, Cebotaru L, Kim H, Chiaravalli M, Boletta A, Qian F, Guggino WB.

J Biol Chem. 2014 Mar 7;289(10):6404-14. doi: 10.1074/jbc.M113.501205. Epub 2014 Jan 23.

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