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Items: 1 to 20 of 102

1.

Synthesis, antiproliferative activity, and molecular docking studies of 4-chlorothiocolchicine analogues.

Klejborowska G, Moshari M, Maj E, Majcher U, Preto J, Wietrzyk J, Tuszynski JA, Huczyński A.

Chem Biol Drug Des. 2020 Jan;95(1):182-191. doi: 10.1111/cbdd.13618. Epub 2019 Sep 20.

PMID:
31483093
2.

Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents.

Majcher U, Klejborowska G, Kaik M, Maj E, Wietrzyk J, Moshari M, Preto J, Tuszynski JA, Huczyński A.

Cells. 2018 Nov 19;7(11). pii: E216. doi: 10.3390/cells7110216.

3.

Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives.

Majcher U, Klejborowska G, Moshari M, Maj E, Wietrzyk J, Bartl F, Tuszynski JA, Huczyński A.

Cells. 2018 Nov 1;7(11). pii: E192. doi: 10.3390/cells7110192.

4.

Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes.

Majcher U, Urbaniak A, Maj E, Moshari M, Delgado M, Wietrzyk J, Bartl F, Chambers TC, Tuszynski JA, Huczyński A.

Bioorg Chem. 2018 Dec;81:553-566. doi: 10.1016/j.bioorg.2018.09.004. Epub 2018 Sep 12.

PMID:
30248507
5.

Synthesis, biological evaluation and molecular docking studies of new amides of 4-bromothiocolchicine as anticancer agents.

Klejborowska G, Urbaniak A, Preto J, Maj E, Moshari M, Wietrzyk J, Tuszynski JA, Chambers TC, Huczyński A.

Bioorg Med Chem. 2019 Dec 1;27(23):115144. doi: 10.1016/j.bmc.2019.115144. Epub 2019 Oct 8.

6.

Synthesis, antiproliferative activity and molecular docking of Colchicine derivatives.

Huczyński A, Majcher U, Maj E, Wietrzyk J, Janczak J, Moshari M, Tuszynski JA, Bartl F.

Bioorg Chem. 2016 Feb;64:103-12. doi: 10.1016/j.bioorg.2016.01.002. Epub 2016 Jan 12.

PMID:
26794327
7.

Synthesis, antiproliferative and antibacterial evaluation of C-ring modified colchicine analogues.

Huczyński A, Rutkowski J, Popiel K, Maj E, Wietrzyk J, Stefańska J, Majcher U, Bartl F.

Eur J Med Chem. 2015 Jan 27;90:296-301. doi: 10.1016/j.ejmech.2014.11.037. Epub 2014 Nov 22.

PMID:
25437616
8.

Colchicine-like β-acetamidoketones as inhibitors of microtubule polymerization: Design, synthesis and biological evaluation of in vitro anticancer activity.

Karimikia E, Behravan J, Zarghi A, Ghandadi M, Omid Malayeri S, Ghodsi R.

Iran J Basic Med Sci. 2019 Oct;22(10):1138-1146. doi: 10.22038/ijbms.2019.34760.8242.

9.

Synthesis and biological evaluation of novel benzo[c]acridine-diones as potential anticancer agents and tubulin polymerization inhibitors.

Behbahani FS, Tabeshpour J, Mirzaei S, Golmakaniyoon S, Tayarani-Najaran Z, Ghasemi A, Ghodsi R.

Arch Pharm (Weinheim). 2019 Jun;352(6):e1800307. doi: 10.1002/ardp.201800307. Epub 2019 Apr 23.

PMID:
31012156
10.

Synthesis and biological evaluation of indole-2-carbohydrazides and thiazolidinyl-indole-2-carboxamides as potent tubulin polymerization inhibitors.

Kazan F, Yagci ZB, Bai R, Ozkirimli E, Hamel E, Ozkirimli S.

Comput Biol Chem. 2019 Jun;80:512-523. doi: 10.1016/j.compbiolchem.2019.05.002. Epub 2019 May 11.

PMID:
31185422
11.

Design, synthesis, biological and in silico evaluation of coumarin-hydrazone derivatives as tubulin targeted antiproliferative agents.

Govindaiah P, Dumala N, Mattan I, Grover P, Jaya Prakash M.

Bioorg Chem. 2019 Oct;91:103143. doi: 10.1016/j.bioorg.2019.103143. Epub 2019 Jul 22.

PMID:
31374528
12.

Docking, synthesis and antiproliferative activity of N-acylhydrazone derivatives designed as combretastatin A4 analogues.

do Amaral DN, Cavalcanti BC, Bezerra DP, Ferreira PM, Castro Rde P, Sabino JR, Machado CM, Chammas R, Pessoa C, Sant'Anna CM, Barreiro EJ, Lima LM.

PLoS One. 2014 Mar 10;9(3):e85380. doi: 10.1371/journal.pone.0085380. eCollection 2014.

13.

Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents.

Madadi NR, Penthala NR, Ketkar A, Eoff RL, Trujullo-Alonso V, Guzman ML, Crooks PA.

Anticancer Agents Med Chem. 2018;18(4):556-564. doi: 10.2174/1871521409666170412115703.

PMID:
28403783
14.

Synthesis, biological evaluation and molecular docking studies of aminochalcone derivatives as potential anticancer agents by targeting tubulin colchicine binding site.

Wang G, Peng Z, Zhang J, Qiu J, Xie Z, Gong Z.

Bioorg Chem. 2018 Aug;78:332-340. doi: 10.1016/j.bioorg.2018.03.028. Epub 2018 Apr 3.

PMID:
29627654
15.

Chemical synthesis, pharmacological evaluation and in silico analysis of new 2,3,3a,4,5,6-hexahydrocyclopenta[c]pyrazole derivatives as potential anti-mitotic agents.

Minu M, Singh D, Mahaddalkar T, Lopus M, Winter P, Ayoub AT, Missiaen K, Tilli TM, Pasdar M, Tuszynski J.

Bioorg Med Chem Lett. 2016 Aug 15;26(16):3855-61. doi: 10.1016/j.bmcl.2016.07.025. Epub 2016 Jul 9.

PMID:
27449957
16.

Stereochemical preference toward oncotarget: Design, synthesis and in vitro anticancer evaluation of diastereomeric β-lactams.

Olazarán-Santibáñez F, Bandyopadhyay D, Carranza-Rosales P, Rivera G, Balderas-Rentería I.

Oncotarget. 2017 Jun 6;8(23):37773-37782. doi: 10.18632/oncotarget.18077.

17.

Design, synthesis and molecular modeling of new 4-phenylcoumarin derivatives as tubulin polymerization inhibitors targeting MCF-7 breast cancer cells.

Batran RZ, Kassem AF, Abbas EMH, Elseginy SA, Mounier MM.

Bioorg Med Chem. 2018 Jul 23;26(12):3474-3490. doi: 10.1016/j.bmc.2018.05.022. Epub 2018 May 16.

PMID:
29793751
18.

3-Vinylazetidin-2-Ones: Synthesis, Antiproliferative and Tubulin Destabilizing Activity in MCF-7 and MDA-MB-231 Breast Cancer Cells.

Wang S, Malebari AM, Greene TF, O'Boyle NM, Fayne D, Nathwani SM, Twamley B, McCabe T, Keely NO, Zisterer DM, Meegan MJ.

Pharmaceuticals (Basel). 2019 Apr 11;12(2). pii: E56. doi: 10.3390/ph12020056.

19.

Synthesis and biological evaluation of quinoline analogues of flavones as potential anticancer agents and tubulin polymerization inhibitors.

Shobeiri N, Rashedi M, Mosaffa F, Zarghi A, Ghandadi M, Ghasemi A, Ghodsi R.

Eur J Med Chem. 2016 May 23;114:14-23. doi: 10.1016/j.ejmech.2016.02.069. Epub 2016 Mar 2.

PMID:
26974371
20.

Interactions of long-chain homologues of colchicine with tubulin.

Marzo-Mas A, Barbier P, Breuzard G, Allegro D, Falomir E, Murga J, Carda M, Peyrot V, Marco JA.

Eur J Med Chem. 2017 Jan 27;126:526-535. doi: 10.1016/j.ejmech.2016.11.049. Epub 2016 Nov 23.

PMID:
27915168

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