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Items: 1 to 20 of 92

1.

Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF.

Elmenoufy AH, Gentile F, Jay D, Karimi-Busheri F, Yang X, Soueidan OM, Weilbeer C, Mani RS, Barakat KH, Tuszynski JA, Weinfeld M, West FG.

J Med Chem. 2019 Sep 12;62(17):7684-7696. doi: 10.1021/acs.jmedchem.9b00326. Epub 2019 Aug 22.

PMID:
31369707
2.

Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells.

Arora S, Heyza J, Zhang H, Kalman-Maltese V, Tillison K, Floyd AM, Chalfin EM, Bepler G, Patrick SM.

Oncotarget. 2016 Nov 15;7(46):75104-75117. doi: 10.18632/oncotarget.12072.

3.

Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance.

McNeil EM, Astell KR, Ritchie AM, Shave S, Houston DR, Bakrania P, Jones HM, Khurana P, Wallace C, Chapman T, Wear MA, Walkinshaw MD, Saxty B, Melton DW.

DNA Repair (Amst). 2015 Jul;31:19-28. doi: 10.1016/j.dnarep.2015.04.002. Epub 2015 Apr 22.

PMID:
25956741
4.

Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1.

Tsodikov OV, Enzlin JH, Schärer OD, Ellenberger T.

Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11236-41. Epub 2005 Aug 2.

5.

Computer-Aided Drug Design of Small Molecule Inhibitors of the ERCC1-XPF Protein-Protein Interaction.

Gentile F, Elmenoufy AH, Ciniero G, Jay D, Karimi-Busheri F, Barakat KH, Weinfeld M, West FG, Tuszynski JA.

Chem Biol Drug Des. 2019 Dec 31. doi: 10.1111/cbdd.13660. [Epub ahead of print]

PMID:
31891209
7.

Targeting the DNA Repair Endonuclease ERCC1-XPF with Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) and Its Prodrug to Enhance Cisplatin Efficacy in Human Cancer Cells.

Heyza JR, Arora S, Zhang H, Conner KL, Lei W, Floyd AM, Deshmukh RR, Sarver J, Trabbic CJ, Erhardt P, Chan TH, Dou QP, Patrick SM.

Nutrients. 2018 Nov 3;10(11). pii: E1644. doi: 10.3390/nu10111644.

8.

Downregulation of XPF-ERCC1 enhances cisplatin efficacy in cancer cells.

Arora S, Kothandapani A, Tillison K, Kalman-Maltese V, Patrick SM.

DNA Repair (Amst). 2010 Jul 1;9(7):745-53. doi: 10.1016/j.dnarep.2010.03.010. Epub 2010 Apr 24.

9.

ERCC1-XPF endonuclease facilitates DNA double-strand break repair.

Ahmad A, Robinson AR, Duensing A, van Drunen E, Beverloo HB, Weisberg DB, Hasty P, Hoeijmakers JH, Niedernhofer LJ.

Mol Cell Biol. 2008 Aug;28(16):5082-92. doi: 10.1128/MCB.00293-08. Epub 2008 Jun 9.

10.

Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.

Ahmad A, Enzlin JH, Bhagwat NR, Wijgers N, Raams A, Appledoorn E, Theil AF, J Hoeijmakers JH, Vermeulen W, J Jaspers NG, Schärer OD, Niedernhofer LJ.

PLoS Genet. 2010 Mar 5;6(3):e1000871. doi: 10.1371/journal.pgen.1000871.

11.

The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair.

Tripsianes K, Folkers G, Ab E, Das D, Odijk H, Jaspers NG, Hoeijmakers JH, Kaptein R, Boelens R.

Structure. 2005 Dec;13(12):1849-58.

12.

Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue.

Bhagwat NR, Roginskaya VY, Acquafondata MB, Dhir R, Wood RD, Niedernhofer LJ.

Cancer Res. 2009 Sep 1;69(17):6831-8. doi: 10.1158/0008-5472.CAN-09-1237.

13.

Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.

Su Y, Orelli B, Madireddy A, Niedernhofer LJ, Schärer OD.

J Biol Chem. 2012 Jun 22;287(26):21846-55. doi: 10.1074/jbc.M111.337899. Epub 2012 Apr 30.

14.

DCAF7 is required for maintaining the cellular levels of ERCC1-XPF and nucleotide excision repair.

Kawara H, Akahori R, Wakasugi M, Sancar A, Matsunaga T.

Biochem Biophys Res Commun. 2019 Oct 29;519(1):204-210. doi: 10.1016/j.bbrc.2019.08.147. Epub 2019 Sep 4.

PMID:
31493872
15.

Single-stranded DNA Binding by the Helix-Hairpin-Helix Domain of XPF Protein Contributes to the Substrate Specificity of the ERCC1-XPF Protein Complex.

Das D, Faridounnia M, Kovacic L, Kaptein R, Boelens R, Folkers GE.

J Biol Chem. 2017 Feb 17;292(7):2842-2853. doi: 10.1074/jbc.M116.747857. Epub 2016 Dec 27.

16.

ERCC1/XPF Is Important for Repair of DNA Double-Strand Breaks Containing Secondary Structures.

Li S, Lu H, Wang Z, Hu Q, Wang H, Xiang R, Chiba T, Wu X.

iScience. 2019 Jun 28;16:63-78. doi: 10.1016/j.isci.2019.05.017. Epub 2019 May 16.

17.

The XPF-ERCC1 Complex Is Essential for Genome Stability and Is Involved in the Mechanism of Gene Targeting in Physcomitrella patens.

Guyon-Debast A, Rossetti P, Charlot F, Epert A, Neuhaus JM, Schaefer DG, Nogué F.

Front Plant Sci. 2019 May 9;10:588. doi: 10.3389/fpls.2019.00588. eCollection 2019.

18.

The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells.

Niedernhofer LJ, Essers J, Weeda G, Beverloo B, de Wit J, Muijtjens M, Odijk H, Hoeijmakers JH, Kanaar R.

EMBO J. 2001 Nov 15;20(22):6540-9.

19.
20.

Removal of reactive oxygen species-induced 3'-blocked ends by XPF-ERCC1.

Fisher LA, Samson L, Bessho T.

Chem Res Toxicol. 2011 Nov 21;24(11):1876-81. doi: 10.1021/tx200221j. Epub 2011 Oct 18.

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