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The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy.

Klimek C, Jahnke R, Wördehoff J, Kathage B, Stadel D, Behrends C, Hergovich A, Höhfeld J.

Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1556-1566. doi: 10.1016/j.bbamcr.2019.07.007. Epub 2019 Jul 19.


The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1.

Kathage B, Gehlert S, Ulbricht A, Lüdecke L, Tapia VE, Orfanos Z, Wenzel D, Bloch W, Volkmer R, Fleischmann BK, Fürst DO, Höhfeld J.

Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):62-75. doi: 10.1016/j.bbamcr.2016.10.007. Epub 2016 Oct 15.


Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.

Ulbricht A, Eppler FJ, Tapia VE, van der Ven PF, Hampe N, Hersch N, Vakeel P, Stadel D, Haas A, Saftig P, Behrends C, Fürst DO, Volkmer R, Hoffmann B, Kolanus W, Höhfeld J.

Curr Biol. 2013 Mar 4;23(5):430-5. doi: 10.1016/j.cub.2013.01.064. Epub 2013 Feb 21.


Chaperone-assisted selective autophagy is essential for muscle maintenance.

Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, Fürst DO, Saftig P, Saint R, Fleischmann BK, Hoch M, Höhfeld J.

Curr Biol. 2010 Jan 26;20(2):143-8. doi: 10.1016/j.cub.2009.11.022. Epub 2010 Jan 7.


BAG3-mediated proteostasis at a glance.

Klimek C, Kathage B, Wördehoff J, Höhfeld J.

J Cell Sci. 2017 Sep 1;130(17):2781-2788. doi: 10.1242/jcs.203679. Epub 2017 Aug 14. Review.


BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes.

Ji C, Tang M, Zeidler C, Höhfeld J, Johnson GV.

Autophagy. 2019 Jul;15(7):1199-1213. doi: 10.1080/15548627.2019.1580096. Epub 2019 Mar 1.


Chaperone-assisted proteostasis is essential for mechanotransduction in mammalian cells.

Ulbricht A, Arndt V, Höhfeld J.

Commun Integr Biol. 2013 Jul 1;6(4):e24925. doi: 10.4161/cib.24925. Epub 2013 Jun 11.


A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis.

Fuchs M, Luthold C, Guilbert SM, Varlet AA, Lambert H, Jetté A, Elowe S, Landry J, Lavoie JN.

PLoS Genet. 2015 Oct 23;11(10):e1005582. doi: 10.1371/journal.pgen.1005582. eCollection 2015 Oct.


HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy.

Carra S, Seguin SJ, Lambert H, Landry J.

J Biol Chem. 2008 Jan 18;283(3):1437-44. Epub 2007 Nov 15.


Fine-tuning of actin dynamics by the HSPB8-BAG3 chaperone complex facilitates cytokinesis and contributes to its impact on cell division.

Varlet AA, Fuchs M, Luthold C, Lambert H, Landry J, Lavoie JN.

Cell Stress Chaperones. 2017 Jul;22(4):553-567. doi: 10.1007/s12192-017-0780-2. Epub 2017 Mar 8.


Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle.

Ulbricht A, Gehlert S, Leciejewski B, Schiffer T, Bloch W, Höhfeld J.

Autophagy. 2015;11(3):538-46. doi: 10.1080/15548627.2015.1017186.


HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy.

Carra S, Seguin SJ, Landry J.

Autophagy. 2008 Feb;4(2):237-9. Epub 2007 Dec 11. Review.


HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency.

Guilbert SM, Lambert H, Rodrigue MA, Fuchs M, Landry J, Lavoie JN.

FASEB J. 2018 Jul;32(7):3518-3535. doi: 10.1096/fj.201700558RR. Epub 2018 Feb 5.


HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylation.

Carra S, Brunsting JF, Lambert H, Landry J, Kampinga HH.

J Biol Chem. 2009 Feb 27;284(9):5523-32. doi: 10.1074/jbc.M807440200. Epub 2008 Dec 29.


Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation.

Bettoun A, Joffre C, Zago G, Surdez D, Vallerand D, Gundogdu R, Sharif AA, Gomez M, Cascone I, Meunier B, White MA, Codogno P, Parrini MC, Camonis JH, Hergovich A.

Oncotarget. 2016 Jul 12;7(28):44142-44160. doi: 10.18632/oncotarget.9875. Erratum in: Oncotarget. 2018 Apr 27;9(32):22870.


Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction.

Fuchs M, Poirier DJ, Seguin SJ, Lambert H, Carra S, Charette SJ, Landry J.

Biochem J. 2009 Dec 14;425(1):245-55. doi: 10.1042/BJ20090907. Erratum in: Biochem J. 2010 Aug 27;430(3):559.


The Regulation of the Small Heat Shock Protein B8 in Misfolding Protein Diseases Causing Motoneuronal and Muscle Cell Death.

Cristofani R, Rusmini P, Galbiati M, Cicardi ME, Ferrari V, Tedesco B, Casarotto E, Chierichetti M, Messi E, Piccolella M, Carra S, Crippa V, Poletti A.

Front Neurosci. 2019 Aug 2;13:796. doi: 10.3389/fnins.2019.00796. eCollection 2019. Review.


Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress.

Liang J, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Han Z, Harty RN.

PLoS Pathog. 2017 Jan 11;13(1):e1006132. doi: 10.1371/journal.ppat.1006132. eCollection 2017 Jan. Erratum in: PLoS Pathog. 2017 Jul 19;13(7):e1006519.


The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases.

Rusmini P, Cristofani R, Galbiati M, Cicardi ME, Meroni M, Ferrari V, Vezzoli G, Tedesco B, Messi E, Piccolella M, Carra S, Crippa V, Poletti A.

Front Mol Neurosci. 2017 Jun 21;10:176. doi: 10.3389/fnmol.2017.00176. eCollection 2017. Review.


The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy.

Joffre C, Dupont N, Hoa L, Gomez V, Pardo R, Gonçalves-Pimentel C, Achard P, Bettoun A, Meunier B, Bauvy C, Cascone I, Codogno P, Fanto M, Hergovich A, Camonis J.

Curr Biol. 2015 Oct 5;25(19):2479-92. doi: 10.1016/j.cub.2015.08.031. Epub 2015 Sep 17.

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