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Items: 1 to 20 of 101

1.

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.

Minuesa G, Albanese SK, Xie W, Kazansky Y, Worroll D, Chow A, Schurer A, Park SM, Rotsides CZ, Taggart J, Rizzi A, Naden LN, Chou T, Gourkanti S, Cappel D, Passarelli MC, Fairchild L, Adura C, Glickman JF, Schulman J, Famulare C, Patel M, Eibl JK, Ross GM, Bhattacharya S, Tan DS, Leslie CS, Beuming T, Patel DJ, Goldgur Y, Chodera JD, Kharas MG.

Nat Commun. 2019 Jun 19;10(1):2691. doi: 10.1038/s41467-019-10523-3.

2.

Musashi-2 Silencing Exerts Potent Activity against Acute Myeloid Leukemia and Enhances Chemosensitivity to Daunorubicin.

Han Y, Ye A, Zhang Y, Cai Z, Wang W, Sun L, Jiang S, Wu J, Yu K, Zhang S.

PLoS One. 2015 Aug 26;10(8):e0136484. doi: 10.1371/journal.pone.0136484. eCollection 2015.

3.

Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling.

Duggimpudi S, Kloetgen A, Maney SK, Münch PC, Hezaveh K, Shaykhalishahi H, Hoyer W, McHardy AC, Lang PA, Borkhardt A, Hoell JI.

J Biol Chem. 2018 Oct 5;293(40):15359-15369. doi: 10.1074/jbc.RA118.002243. Epub 2018 Aug 20.

PMID:
30126842
4.

Developmental expression of Musashi-1 and Musashi-2 RNA-binding proteins during spermatogenesis: analysis of the deleterious effects of dysregulated expression.

Sutherland JM, Fraser BA, Sobinoff AP, Pye VJ, Davidson TL, Siddall NA, Koopman P, Hime GR, McLaughlin EA.

Biol Reprod. 2014 May 1;90(5):92. doi: 10.1095/biolreprod.113.115261. Print 2014 May.

PMID:
24671879
5.

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.

Kharas MG, Lengner CJ, Al-Shahrour F, Bullinger L, Ball B, Zaidi S, Morgan K, Tam W, Paktinat M, Okabe R, Gozo M, Einhorn W, Lane SW, Scholl C, Fröhling S, Fleming M, Ebert BL, Gilliland DG, Jaenisch R, Daley GQ.

Nat Med. 2010 Aug;16(8):903-8. doi: 10.1038/nm.2187. Epub 2010 Jul 8.

6.

[Expression of musashi-2 gene in leukemia stem cells from acute myeloid leukemia patients].

Ye AF, Han YX, Zhang SH, Li HY, Chen CQ, Wu JB.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2014 Oct;22(5):1235-8. doi: 10.7534/j.issn.1009-2137.2014.05.009. Chinese.

PMID:
25338564
7.

Musashi RNA-Binding Proteins as Cancer Drivers and Novel Therapeutic Targets.

Kudinov AE, Karanicolas J, Golemis EA, Boumber Y.

Clin Cancer Res. 2017 May 1;23(9):2143-2153. doi: 10.1158/1078-0432.CCR-16-2728. Epub 2017 Jan 31. Review.

8.

Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway.

Zhang H, Tan S, Wang J, Chen S, Quan J, Xian J, Zhang Ss, He J, Zhang L.

Exp Cell Res. 2014 Jan 1;320(1):119-27. doi: 10.1016/j.yexcr.2013.09.009. Epub 2013 Sep 26.

PMID:
24076374
9.

Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.

Park SM, Gönen M, Vu L, Minuesa G, Tivnan P, Barlowe TS, Taggart J, Lu Y, Deering RP, Hacohen N, Figueroa ME, Paietta E, Fernandez HF, Tallman MS, Melnick A, Levine R, Leslie C, Lengner CJ, Kharas MG.

J Clin Invest. 2015 Mar 2;125(3):1286-98. doi: 10.1172/JCI78440. Epub 2015 Feb 9.

10.

Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.

Vu LP, Prieto C, Amin EM, Chhangawala S, Krivtsov A, Calvo-Vidal MN, Chou T, Chow A, Minuesa G, Park SM, Barlowe TS, Taggart J, Tivnan P, Deering RP, Chu LP, Kwon JA, Meydan C, Perales-Paton J, Arshi A, Gönen M, Famulare C, Patel M, Paietta E, Tallman MS, Lu Y, Glass J, Garret-Bakelman FE, Melnick A, Levine R, Al-Shahrour F, Järås M, Hacohen N, Hwang A, Garippa R, Lengner CJ, Armstrong SA, Cerchietti L, Cowley GS, Root D, Doench J, Leslie C, Ebert BL, Kharas MG.

Nat Genet. 2017 Jun;49(6):866-875. doi: 10.1038/ng.3854. Epub 2017 Apr 24.

11.

A 1536-well fluorescence polarization assay to screen for modulators of the MUSASHI family of RNA-binding proteins.

Minuesa G, Antczak C, Shum D, Radu C, Bhinder B, Li Y, Djaballah H, Kharas MG.

Comb Chem High Throughput Screen. 2014;17(7):596-609.

12.

RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus.

Sutherland JM, Sobinoff AP, Fraser BA, Redgrove KA, Davidson TL, Siddall NA, Koopman P, Hime GR, McLaughlin EA.

FASEB J. 2015 Jul;29(7):2759-68. doi: 10.1096/fj.14-265868. Epub 2015 Mar 17.

PMID:
25782991
13.

Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins.

Lan L, Liu H, Smith AR, Appelman C, Yu J, Larsen S, Marquez RT, Wu X, Liu FY, Gao P, Gowthaman R, Karanicolas J, De Guzman RN, Rogers S, Aubé J, Neufeld KL, Xu L.

BMC Cancer. 2018 Aug 10;18(1):809. doi: 10.1186/s12885-018-4704-z.

14.

Aggressive myeloid leukemia formation is directed by the Musashi 2/Numb pathway.

Griner LN, Reuther GW.

Cancer Biol Ther. 2010 Nov 15;10(10):979-82. Epub 2010 Nov 15.

PMID:
21084860
15.

Human oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket.

Lan L, Xing M, Douglas JT, Gao P, Hanzlik RP, Xu L.

Oncotarget. 2017 Nov 20;8(63):106587-106597. doi: 10.18632/oncotarget.22540. eCollection 2017 Dec 5.

16.

Prognostic significance of expression levels of stem cell regulators MSI2 and NUMB in acute myeloid leukemia.

Thol F, Winschel C, Sonntag AK, Damm F, Wagner K, Chaturvedi A, Göhring G, Schlegelberger B, Lübbert M, Fiedler W, Kirchner H, Krauter J, Ganser A, Heuser M.

Ann Hematol. 2013 Mar;92(3):315-23. doi: 10.1007/s00277-012-1637-5. Epub 2012 Dec 12.

PMID:
23233047
17.

The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins.

Li N, Yousefi M, Nakauka-Ddamba A, Li F, Vandivier L, Parada K, Woo DH, Wang S, Naqvi AS, Rao S, Tobias J, Cedeno RJ, Minuesa G, Y K, Barlowe TS, Valvezan A, Shankar S, Deering RP, Klein PS, Jensen ST, Kharas MG, Gregory BD, Yu Z, Lengner CJ.

Cell Rep. 2015 Dec 22;13(11):2440-2455. doi: 10.1016/j.celrep.2015.11.022. Epub 2015 Dec 8.

18.

Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis.

Sutherland JM, Sobinoff AP, Gunter KM, Fraser BA, Pye V, Bernstein IR, Boon E, Siddall NA, De Andres LI, Hime GR, Holt JE, Graf T, McLaughlin EA.

Biomolecules. 2015 Jun 26;5(3):1228-44. doi: 10.3390/biom5031228.

19.

Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1.

Lan L, Appelman C, Smith AR, Yu J, Larsen S, Marquez RT, Liu H, Wu X, Gao P, Roy A, Anbanandam A, Gowthaman R, Karanicolas J, De Guzman RN, Rogers S, Aubé J, Ji M, Cohen RS, Neufeld KL, Xu L.

Mol Oncol. 2015 Aug;9(7):1406-20. doi: 10.1016/j.molonc.2015.03.014. Epub 2015 Apr 10.

20.

Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease.

Sengupta U, Montalbano M, McAllen S, Minuesa G, Kharas M, Kayed R.

Acta Neuropathol Commun. 2018 Oct 26;6(1):113. doi: 10.1186/s40478-018-0615-0.

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