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Methods to Study Trinucleotide Repeat Instability Induced by DNA Damage and Repair.

Lai Y, Lei R, Ren Y, Liu Y.

Methods Mol Biol. 2019;1999:87-101. doi: 10.1007/978-1-4939-9500-4_5.


Modulation of trinucleotide repeat instability by DNA polymerase β polymorphic variant R137Q.

Ren Y, Lai Y, Laverde EE, Lei R, Rein HL, Liu Y.

PLoS One. 2017 May 5;12(5):e0177299. doi: 10.1371/journal.pone.0177299. eCollection 2017.


Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion.

Xu M, Lai Y, Torner J, Zhang Y, Zhang Z, Liu Y.

Nucleic Acids Res. 2014 Apr;42(6):3675-91. doi: 10.1093/nar/gkt1372. Epub 2014 Jan 14.


An oxidized abasic lesion inhibits base excision repair leading to DNA strand breaks in a trinucleotide repeat tract.

Beaver JM, Lai Y, Rolle SJ, Weng L, Greenberg MM, Liu Y.

PLoS One. 2018 Feb 1;13(2):e0192148. doi: 10.1371/journal.pone.0192148. eCollection 2018.


Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.

Hubert L Jr, Lin Y, Dion V, Wilson JH.

Hum Mol Genet. 2011 Dec 15;20(24):4822-30. doi: 10.1093/hmg/ddr421. Epub 2011 Sep 15.


DNA repair and trinucleotide repeat instability.

Lahue RS, Slater DL.

Front Biosci. 2003 May 1;8:s653-65. Review.


Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice.

Goula AV, Berquist BR, Wilson DM 3rd, Wheeler VC, Trottier Y, Merienne K.

PLoS Genet. 2009 Dec;5(12):e1000749. doi: 10.1371/journal.pgen.1000749. Epub 2009 Dec 4.


Bidirectional transcription of trinucleotide repeats: roles for excision repair.

Budworth H, McMurray CT.

DNA Repair (Amst). 2013 Aug;12(8):672-84. doi: 10.1016/j.dnarep.2013.04.019. Epub 2013 May 11. Review.


Instability of CTG repeats is governed by the position of a DNA base lesion through base excision repair.

Lai Y, Xu M, Zhang Z, Liu Y.

PLoS One. 2013;8(2):e56960. doi: 10.1371/journal.pone.0056960. Epub 2013 Feb 26.


Proliferating cell nuclear antigen prevents trinucleotide repeat expansions by promoting repeat deletion and hairpin removal.

Beaver JM, Lai Y, Rolle SJ, Liu Y.

DNA Repair (Amst). 2016 Dec;48:17-29. doi: 10.1016/j.dnarep.2016.10.006. Epub 2016 Oct 22.


Nucleotide excision repair and the 26S proteasome function together to promote trinucleotide repeat expansions.

Concannon C, Lahue RS.

DNA Repair (Amst). 2014 Jan;13:42-9. doi: 10.1016/j.dnarep.2013.11.004. Epub 2013 Dec 17.


Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice.

Møllersen L, Rowe AD, Illuzzi JL, Hildrestrand GA, Gerhold KJ, Tveterås L, Bjølgerud A, Wilson DM 3rd, Bjørås M, Klungland A.

Hum Mol Genet. 2012 Nov 15;21(22):4939-47. doi: 10.1093/hmg/dds337. Epub 2012 Aug 21.


The deoxyribose phosphate lyase of DNA polymerase β suppresses a processive DNA synthesis to prevent trinucleotide repeat instability.

Lai Y, Weizmann Y, Liu Y.

Nucleic Acids Res. 2018 Sep 28;46(17):8940-8952. doi: 10.1093/nar/gky700.


Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability.

Cilli P, Ventura I, Minoprio A, Meccia E, Martire A, Wilson SH, Bignami M, Mazzei F.

Nucleic Acids Res. 2016 Jun 20;44(11):5190-203. doi: 10.1093/nar/gkw170. Epub 2016 Mar 14.


DNA base excision repair: a mechanism of trinucleotide repeat expansion.

Liu Y, Wilson SH.

Trends Biochem Sci. 2012 Apr;37(4):162-72. doi: 10.1016/j.tibs.2011.12.002. Epub 2012 Jan 27. Review.


Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR.

Chatterjee N, Lin Y, Wilson JH.

DNA Repair (Amst). 2016 Jun;42:26-32. doi: 10.1016/j.dnarep.2016.03.016. Epub 2016 Apr 16.


Instability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesis.

Liu G, Leffak M.

Cell Biosci. 2012 Feb 27;2(1):7. doi: 10.1186/2045-3701-2-7.


Incidence and persistence of 8-oxo-7,8-dihydroguanine within a hairpin intermediate exacerbates a toxic oxidation cycle associated with trinucleotide repeat expansion.

Jarem DA, Wilson NR, Schermerhorn KM, Delaney S.

DNA Repair (Amst). 2011 Aug 15;10(8):887-96. doi: 10.1016/j.dnarep.2011.06.003. Epub 2011 Jul 2.


CAG*CTG repeat instability in cultured human astrocytes.

Farrell BT, Lahue RS.

Nucleic Acids Res. 2006;34(16):4495-505. Epub 2006 Aug 31.


DNA tandem repeat instability in the Escherichia coli chromosome is stimulated by mismatch repair at an adjacent CAG·CTG trinucleotide repeat.

Blackwood JK, Okely EA, Zahra R, Eykelenboom JK, Leach DR.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22582-6. doi: 10.1073/pnas.1012906108. Epub 2010 Dec 13.

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