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Items: 1 to 20 of 96

1.

A Novel Caenorhabditis Elegans Proteinopathy Model Shows Changes in mRNA Translational Frameshifting During Aging.

Adamla F, Rollins J, Newsom M, Snow S, Schosserer M, Heissenberger C, Horrocks J, Rogers AN, Ignatova Z.

Cell Physiol Biochem. 2019;52(5):970-983. doi: 10.33594/000000067.

2.

An Expanded CAG Repeat in Huntingtin Causes +1 Frameshifting.

Saffert P, Adamla F, Schieweck R, Atkins JF, Ignatova Z.

J Biol Chem. 2016 Aug 26;291(35):18505-13. doi: 10.1074/jbc.M116.744326. Epub 2016 Jul 5.

3.

A tetracycline-dependent ribozyme switch allows conditional induction of gene expression in Caenorhabditis elegans.

Wurmthaler LA, Sack M, Gense K, Hartig JS, Gamerdinger M.

Nat Commun. 2019 Jan 30;10(1):491. doi: 10.1038/s41467-019-08412-w.

4.

Polyamine-independent Expression of Caenorhabditis elegans Antizyme.

Stegehake D, Kurosinski MA, Schürmann S, Daniel J, Lüersen K, Liebau E.

J Biol Chem. 2015 Jul 17;290(29):18090-101. doi: 10.1074/jbc.M115.644385. Epub 2015 Jun 1.

5.

Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways.

Moily NS, Ormsby AR, Stojilovic A, Ramdzan YM, Diesch J, Hannan RD, Zajac MS, Hannan AJ, Oshlack A, Hatters DM.

Mol Cell Neurosci. 2017 Sep;83:103-112. doi: 10.1016/j.mcn.2017.07.004. Epub 2017 Jul 23.

PMID:
28743452
6.

A new Caenorhabditis elegans model of human huntingtin 513 aggregation and toxicity in body wall muscles.

Lee AL, Ung HM, Sands LP, Kikis EA.

PLoS One. 2017 Mar 10;12(3):e0173644. doi: 10.1371/journal.pone.0173644. eCollection 2017.

7.

Effects of overexpression of huntingtin proteins on mitochondrial integrity.

Wang H, Lim PJ, Karbowski M, Monteiro MJ.

Hum Mol Genet. 2009 Feb 15;18(4):737-52. doi: 10.1093/hmg/ddn404. Epub 2008 Nov 27.

8.

Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington's disease.

Zeng Y, Guo W, Xu G, Wang Q, Feng L, Long S, Liang F, Huang Y, Lu X, Li S, Zhou J, Burgunder JM, Pang J, Pei Z.

Drug Des Devel Ther. 2016 Apr 13;10:1443-51. doi: 10.2147/DDDT.S94666. eCollection 2016.

9.

Vulnerability of newly synthesized proteins to proteostasis stress.

Xu G, Pattamatta A, Hildago R, Pace MC, Brown H, Borchelt DR.

J Cell Sci. 2016 May 1;129(9):1892-901. doi: 10.1242/jcs.176479. Epub 2016 Mar 29.

10.

Depletion of cognate charged transfer RNA causes translational frameshifting within the expanded CAG stretch in huntingtin.

Girstmair H, Saffert P, Rode S, Czech A, Holland G, Bannert N, Ignatova Z.

Cell Rep. 2013 Jan 31;3(1):148-59. doi: 10.1016/j.celrep.2012.12.019. Epub 2013 Jan 24.

11.

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation.

Peskett TR, Rau F, O'Driscoll J, Patani R, Lowe AR, Saibil HR.

Mol Cell. 2018 May 17;70(4):588-601.e6. doi: 10.1016/j.molcel.2018.04.007. Epub 2018 May 10.

12.

N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion.

Chen MZ, Mok SA, Ormsby AR, Muchowski PJ, Hatters DM.

J Huntingtons Dis. 2017;6(1):79-91. doi: 10.3233/JHD-160207.

PMID:
28339398
13.

Widespread protein aggregation as an inherent part of aging in C. elegans.

David DC, Ollikainen N, Trinidad JC, Cary MP, Burlingame AL, Kenyon C.

PLoS Biol. 2010 Aug 10;8(8):e1000450. doi: 10.1371/journal.pbio.1000450.

14.

Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington's disease.

Chen M, Wolynes PG.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4406-4411. doi: 10.1073/pnas.1702237114. Epub 2017 Apr 11.

15.

Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin.

Wang H, Lim PJ, Yin C, Rieckher M, Vogel BE, Monteiro MJ.

Hum Mol Genet. 2006 Mar 15;15(6):1025-41. Epub 2006 Feb 6.

PMID:
16461334
16.

Genetic and pharmacological suppression of polyglutamine-dependent neuronal dysfunction in Caenorhabditis elegans.

Parker JA, Holbert S, Lambert E, Abderrahmane S, Néri C.

J Mol Neurosci. 2004;23(1-2):61-8. Review.

PMID:
15126693
17.

Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity.

Bates EA, Victor M, Jones AK, Shi Y, Hart AC.

J Neurosci. 2006 Mar 8;26(10):2830-8.

18.

Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans.

Rogers AN, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow GJ, Kapahi P.

Cell Metab. 2011 Jul 6;14(1):55-66. doi: 10.1016/j.cmet.2011.05.010.

19.

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans.

Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, Kapahi P.

Aging Cell. 2007 Feb;6(1):111-9.

20.

Polyalanine and polyserine frameshift products in Huntington's disease.

Davies JE, Rubinsztein DC.

J Med Genet. 2006 Nov;43(11):893-6. Epub 2006 Jun 26. Erratum in: J Med Genet. 2007 Feb;44(2):160.

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