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Items: 1 to 20 of 101

1.

Combination of stem cell and gene therapy ameliorates symptoms in Huntington's disease mice.

Cho IK, Hunter CE, Ye S, Pongos AL, Chan AWS.

NPJ Regen Med. 2019 Mar 26;4:7. doi: 10.1038/s41536-019-0066-7. eCollection 2019.

2.

Amelioration of Huntington's disease phenotype in astrocytes derived from iPSC-derived neural progenitor cells of Huntington's disease monkeys.

Cho IK, Yang B, Forest C, Qian L, Chan AWS.

PLoS One. 2019 Mar 21;14(3):e0214156. doi: 10.1371/journal.pone.0214156. eCollection 2019.

3.

Induced Pluripotent HD Monkey Stem Cells Derived Neural Cells for Drug Discovery.

Kunkanjanawan T, Carter R, Ahn KS, Yang J, Parnpai R, Chan AWS.

SLAS Discov. 2017 Jul;22(6):696-705. doi: 10.1177/2472555216685044. Epub 2016 Dec 27.

4.
5.

Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease.

Swarnkar S, Chen Y, Pryor WM, Shahani N, Page DT, Subramaniam S.

Neurobiol Dis. 2015 Oct;82:66-77. doi: 10.1016/j.nbd.2015.05.011. Epub 2015 Jun 3.

PMID:
26048156
6.

FOXOs modulate proteasome activity in human-induced pluripotent stem cells of Huntington's disease and their derived neural cells.

Liu Y, Qiao F, Leiferman PC, Ross A, Schlenker EH, Wang H.

Hum Mol Genet. 2017 Nov 15;26(22):4416-4428. doi: 10.1093/hmg/ddx327.

7.

Reversal of cellular phenotypes in neural cells derived from Huntington's disease monkey-induced pluripotent stem cells.

Carter RL, Chen Y, Kunkanjanawan T, Xu Y, Moran SP, Putkhao K, Yang J, Huang AH, Parnpai R, Chan AW.

Stem Cell Reports. 2014 Oct 14;3(4):585-93. doi: 10.1016/j.stemcr.2014.07.011. Epub 2014 Sep 4.

8.

Viral vector mediated expression of mutant huntingtin in the dorsal raphe produces disease-related neuropathology but not depressive-like behaviors in wildtype mice.

Pitzer M, Lueras J, Warden A, Weber S, McBride J.

Brain Res. 2015 May 22;1608:177-90. doi: 10.1016/j.brainres.2015.02.027. Epub 2015 Feb 28.

9.

Induced Pluripotent Stem Cell-Derived Neural Stem Cell Transplantations Reduced Behavioral Deficits and Ameliorated Neuropathological Changes in YAC128 Mouse Model of Huntington's Disease.

Al-Gharaibeh A, Culver R, Stewart AN, Srinageshwar B, Spelde K, Frollo L, Kolli N, Story D, Paladugu L, Anwar S, Crane A, Wyse R, Maiti P, Dunbar GL, Rossignol J.

Front Neurosci. 2017 Nov 10;11:628. doi: 10.3389/fnins.2017.00628. eCollection 2017.

10.
11.

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.

Wang CE, Tydlacka S, Orr AL, Yang SH, Graham RK, Hayden MR, Li S, Chan AW, Li XJ.

Hum Mol Genet. 2008 Sep 1;17(17):2738-51. doi: 10.1093/hmg/ddn175. Epub 2008 Jun 16.

12.

Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease.

Zhou X, Li G, Kaplan A, Gaschler MM, Zhang X, Hou Z, Jiang M, Zott R, Cremers S, Stockwell BR, Duan W.

Hum Mol Genet. 2018 May 1;27(9):1545-1555. doi: 10.1093/hmg/ddy061.

PMID:
29462355
13.

Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.

Wang N, Gray M, Lu XH, Cantle JP, Holley SM, Greiner E, Gu X, Shirasaki D, Cepeda C, Li Y, Dong H, Levine MS, Yang XW.

Nat Med. 2014 May;20(5):536-41. doi: 10.1038/nm.3514. Epub 2014 Apr 28.

14.

Pathogenic cellular phenotypes are germline transmissible in a transgenic primate model of Huntington's disease.

Putkhao K, Kocerha J, Cho IK, Yang J, Parnpai R, Chan AW.

Stem Cells Dev. 2013 Apr 15;22(8):1198-205. doi: 10.1089/scd.2012.0469. Epub 2013 Jan 15.

15.

Towards a transgenic model of Huntington's disease in a non-human primate.

Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC, Snyder B, Larkin K, Liu J, Orkin J, Fang ZH, Smith Y, Bachevalier J, Zola SM, Li SH, Li XJ, Chan AW.

Nature. 2008 Jun 12;453(7197):921-4. doi: 10.1038/nature06975. Epub 2008 May 18.

16.

Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington's disease patient cells.

Juopperi TA, Kim WR, Chiang CH, Yu H, Margolis RL, Ross CA, Ming GL, Song H.

Mol Brain. 2012 May 21;5:17. doi: 10.1186/1756-6606-5-17.

17.

Reprogramming Huntington monkey skin cells into pluripotent stem cells.

Chan AW, Cheng PH, Neumann A, Yang JJ.

Cell Reprogram. 2010 Oct;12(5):509-17. doi: 10.1089/cell.2010.0019.

18.

miR-196a Ameliorates Cytotoxicity and Cellular Phenotype in Transgenic Huntington's Disease Monkey Neural Cells.

Kunkanjanawan T, Carter RL, Prucha MS, Yang J, Parnpai R, Chan AW.

PLoS One. 2016 Sep 15;11(9):e0162788. doi: 10.1371/journal.pone.0162788. eCollection 2016.

19.

Intrabody gene therapy ameliorates motor, cognitive, and neuropathological symptoms in multiple mouse models of Huntington's disease.

Southwell AL, Ko J, Patterson PH.

J Neurosci. 2009 Oct 28;29(43):13589-602. doi: 10.1523/JNEUROSCI.4286-09.2009.

20.

Germline transmission in transgenic Huntington's disease monkeys.

Moran S, Chi T, Prucha MS, Ahn KS, Connor-Stroud F, Jean S, Gould K, Chan AW.

Theriogenology. 2015 Jul 15;84(2):277-85. doi: 10.1016/j.theriogenology.2015.03.016. Epub 2015 Mar 25.

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