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Items: 1 to 20 of 99

1.

Metabotropic glutamate receptor 5 ablation accelerates age-related neurodegeneration and neuroinflammation.

Carvalho TG, Alves-Silva J, de Souza JM, Real ALCV, Doria JG, Vieira ELM, Gomes GF, de Oliveira AC, Miranda AS, Ribeiro FM.

Neurochem Int. 2019 Jun;126:218-228. doi: 10.1016/j.neuint.2019.03.020. Epub 2019 Mar 29.

PMID:
30930274
2.

Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease.

Doria JG, Silva FR, de Souza JM, Vieira LB, Carvalho TG, Reis HJ, Pereira GS, Dobransky T, Ribeiro FM.

Br J Pharmacol. 2013 Jun;169(4):909-21. doi: 10.1111/bph.12164.

3.

The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease.

Doria JG, de Souza JM, Andrade JN, Rodrigues HA, Guimaraes IM, Carvalho TG, Guatimosim C, Dobransky T, Ribeiro FM.

Neurobiol Dis. 2015 Jan;73:163-73. doi: 10.1016/j.nbd.2014.08.021. Epub 2014 Aug 24.

PMID:
25160573
4.

Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease.

Ribeiro FM, Devries RA, Hamilton A, Guimaraes IM, Cregan SP, Pires RG, Ferguson SS.

Hum Mol Genet. 2014 Apr 15;23(8):2030-42. doi: 10.1093/hmg/ddt598. Epub 2013 Nov 26.

PMID:
24282028
5.

Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson's disease.

Huang YY, Zhang Q, Zhang JN, Zhang YN, Gu L, Yang HM, Xia N, Wang XM, Zhang H.

Brain Behav Immun. 2018 Jul;71:93-107. doi: 10.1016/j.bbi.2018.04.006. Epub 2018 Apr 9.

PMID:
29649522
6.

Metabotropic glutamate receptor 5 as a potential therapeutic target in Huntington's disease.

Ribeiro FM, Hamilton A, Doria JG, Guimaraes IM, Cregan SP, Ferguson SS.

Expert Opin Ther Targets. 2014 Nov;18(11):1293-304. doi: 10.1517/14728222.2014.948419. Epub 2014 Aug 14. Review.

PMID:
25118797
7.

Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury.

Byrnes KR, Loane DJ, Stoica BA, Zhang J, Faden AI.

J Neuroinflammation. 2012 Feb 28;9:43. doi: 10.1186/1742-2094-9-43.

8.

Cortical efferents lacking mutant huntingtin improve striatal neuronal activity and behavior in a conditional mouse model of Huntington's disease.

Estrada-Sánchez AM, Burroughs CL, Cavaliere S, Barton SJ, Chen S, Yang XW, Rebec GV.

J Neurosci. 2015 Mar 11;35(10):4440-51. doi: 10.1523/JNEUROSCI.2812-14.2015.

9.

Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal.

Stoker AK, Olivier B, Markou A.

Psychopharmacology (Berl). 2012 May;221(2):317-27. doi: 10.1007/s00213-011-2578-8. Epub 2011 Dec 3.

10.

Enhanced Ca(2+)-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model.

Lee W, Reyes RC, Gottipati MK, Lewis K, Lesort M, Parpura V, Gray M.

Neurobiol Dis. 2013 Oct;58:192-9. doi: 10.1016/j.nbd.2013.06.002. Epub 2013 Jun 10.

11.

Metabotropic glutamate receptor 5 modulates calcium oscillation and innate immune response induced by lipopolysaccharide in microglial cell.

Liu F, Zhou R, Yan H, Yin H, Wu X, Tan Y, Li L.

Neuroscience. 2014 Dec 5;281:24-34. doi: 10.1016/j.neuroscience.2014.09.034. Epub 2014 Sep 22.

PMID:
25250840
12.

Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice.

Mantovani S, Gordon R, Li R, Christie DC, Kumar V, Woodruff TM.

Hum Mol Genet. 2016 May 1;25(9):1780-91. doi: 10.1093/hmg/ddw050. Epub 2016 Feb 21.

PMID:
26908618
13.

Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice.

Bradbury MJ, Campbell U, Giracello D, Chapman D, King C, Tehrani L, Cosford ND, Anderson J, Varney MA, Strack AM.

J Pharmacol Exp Ther. 2005 Apr;313(1):395-402. Epub 2004 Dec 8.

PMID:
15590770
14.

Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity.

Byrnes KR, Stoica B, Loane DJ, Riccio A, Davis MI, Faden AI.

Glia. 2009 Apr 1;57(5):550-60. doi: 10.1002/glia.20783.

15.

Decreased expression of mGluR5 within the dorsolateral prefrontal cortex in autism and increased microglial number in mGluR5 knockout mice: Pathophysiological and neurobehavioral implications.

Chana G, Laskaris L, Pantelis C, Gillett P, Testa R, Zantomio D, Burrows EL, Hannan AJ, Everall IP, Skafidas E.

Brain Behav Immun. 2015 Oct;49:197-205. doi: 10.1016/j.bbi.2015.05.009. Epub 2015 Jun 5.

PMID:
26052099
16.

BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates.

Manfré G, Novati A, Faccini I, Rossetti AC, Bosch K, Molteni R, Riva MA, Van der Harst JE, Nguyen HP, Homberg JR.

PLoS One. 2018 Feb 7;13(2):e0192289. doi: 10.1371/journal.pone.0192289. eCollection 2018.

17.

Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson's disease.

Black YD, Xiao D, Pellegrino D, Kachroo A, Brownell AL, Schwarzschild MA.

Neurosci Lett. 2010 Dec 17;486(3):161-5. doi: 10.1016/j.neulet.2010.09.043. Epub 2010 Sep 18.

18.

Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis.

Paquet M, Ribeiro FM, Guadagno J, Esseltine JL, Ferguson SS, Cregan SP.

Mol Brain. 2013 Feb 14;6:9. doi: 10.1186/1756-6606-6-9.

19.

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.

Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F.

Neuropharmacology. 2018 Jan;128:301-313. doi: 10.1016/j.neuropharm.2017.10.026. Epub 2017 Oct 25.

20.

Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease.

Rocher AB, Gubellini P, Merienne N, Boussicault L, Petit F, Gipchtein P, Jan C, Hantraye P, Brouillet E, Bonvento G.

Neurobiol Dis. 2016 Feb;86:131-9. doi: 10.1016/j.nbd.2015.10.016. Epub 2015 Nov 25.

PMID:
26626081

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