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Items: 1 to 20 of 106

1.

Dynasore Suppresses mTORC1 Activity and Induces Autophagy to Regulate the Clearance of Protein Aggregates in Neurodegenerative Diseases.

Chen Y, Xu S, Wang N, Ma Q, Peng P, Yu Y, Zhang L, Ying Z, Wang H.

Neurotox Res. 2019 Mar 29. doi: 10.1007/s12640-019-00027-9. [Epub ahead of print]

PMID:
30924108
2.

Autophagy and apoptosis dysfunction in neurodegenerative disorders.

Ghavami S, Shojaei S, Yeganeh B, Ande SR, Jangamreddy JR, Mehrpour M, Christoffersson J, Chaabane W, Moghadam AR, Kashani HH, Hashemi M, Owji AA, Łos MJ.

Prog Neurobiol. 2014 Jan;112:24-49. doi: 10.1016/j.pneurobio.2013.10.004. Epub 2013 Nov 6. Review.

3.

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.

Rusmini P, Cortese K, Crippa V, Cristofani R, Cicardi ME, Ferrari V, Vezzoli G, Tedesco B, Meroni M, Messi E, Piccolella M, Galbiati M, Garrè M, Morelli E, Vaccari T, Poletti A.

Autophagy. 2019 Apr;15(4):631-651. doi: 10.1080/15548627.2018.1535292. Epub 2018 Nov 5.

PMID:
30335591
4.

Assessing Autophagic Activity and Aggregate Formation of Mutant Huntingtin in Mammalian Cells.

Stamatakou E, Zhu Y, Rubinsztein DC.

Methods Mol Biol. 2018;1780:17-29. doi: 10.1007/978-1-4939-7825-0_2.

PMID:
29856012
5.

VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.

Arhzaouy K, Papadopoulos C, Schulze N, Pittman SK, Meyer H, Weihl CC.

Autophagy. 2019 Jan 18:1-18. doi: 10.1080/15548627.2019.1569933. [Epub ahead of print]

PMID:
30654731
6.

TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.

Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J, Ying Z, Wang G.

EMBO J. 2016 Jan 18;35(2):121-42. doi: 10.15252/embj.201591998. Epub 2015 Dec 23.

7.
8.

ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models.

Wold MS, Lim J, Lachance V, Deng Z, Yue Z.

Mol Neurodegener. 2016 Dec 9;11(1):76.

9.

TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities.

Cortes CJ, La Spada AR.

Neurobiol Dis. 2019 Feb;122:83-93. doi: 10.1016/j.nbd.2018.05.012. Epub 2018 May 28. Review.

PMID:
29852219
10.

Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis.

King MA, Hands S, Hafiz F, Mizushima N, Tolkovsky AM, Wyttenbach A.

Mol Pharmacol. 2008 Apr;73(4):1052-63. doi: 10.1124/mol.107.043398. Epub 2008 Jan 16.

PMID:
18199701
11.

mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases.

Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, Chaudhury A, Bajaj L, Bondar VV, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson JR, Pereira FA, Pautler RG, Rodney GG, Cooper JD, Sardiello M.

Nat Commun. 2017 Feb 6;8:14338. doi: 10.1038/ncomms14338. Erratum in: Nat Commun. 2017 Jun 13;8:15793.

12.

The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins.

Wang P, Li B, Zhou L, Fei E, Wang G.

Neuroscience. 2011 Sep 8;190:43-55. doi: 10.1016/j.neuroscience.2011.06.008. Epub 2011 Jun 13.

PMID:
21684323
13.

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.

Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC.

Cell Death Differ. 2009 Jan;16(1):46-56. doi: 10.1038/cdd.2008.110. Epub 2008 Jul 18. Review.

14.

TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners.

Ying Z, Xia Q, Hao Z, Xu D, Wang M, Wang H, Wang G.

Autophagy. 2016;12(4):707-8. doi: 10.1080/15548627.2016.1151596.

15.

p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies.

Saitoh Y, Fujikake N, Okamoto Y, Popiel HA, Hatanaka Y, Ueyama M, Suzuki M, Gaumer S, Murata M, Wada K, Nagai Y.

J Biol Chem. 2015 Jan 16;290(3):1442-53. doi: 10.1074/jbc.M114.590281. Epub 2014 Dec 5.

16.

Oblongifolin C suppresses lysosomal function independently of TFEB nuclear translocation.

Wu M, Lao YZ, Tan HS, Lu G, Ren Y, Zheng ZQ, Yi J, Fu WW, Shen HM, Xu HX.

Acta Pharmacol Sin. 2018 Oct 17. doi: 10.1038/s41401-018-0167-7. [Epub ahead of print]

PMID:
30333555
17.

Inhibition of MEK5 suppresses TDP-43 toxicity via the mTOR-independent activation of the autophagy-lysosome pathway.

Jo M, Lee S, Kim K, Lee S, Kim SR, Kim HJ.

Biochem Biophys Res Commun. 2019 Apr 17. pii: S0006-291X(19)30730-2. doi: 10.1016/j.bbrc.2019.04.088. [Epub ahead of print]

PMID:
31005259
18.

Polyglutamine tracts regulate beclin 1-dependent autophagy.

Ashkenazi A, Bento CF, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, Squitieri F, Hardenberg MC, Imarisio S, Menzies FM, Rubinsztein DC.

Nature. 2017 May 4;545(7652):108-111. doi: 10.1038/nature22078. Epub 2017 Apr 26.

19.

TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis.

Wang W, Xia Z, Farré JC, Subramani S.

Autophagy. 2018;14(9):1574-1585. doi: 10.1080/15548627.2018.1463120. Epub 2018 Aug 21.

PMID:
29940807
20.

Gypenoside XVII Enhances Lysosome Biogenesis and Autophagy Flux and Accelerates Autophagic Clearance of Amyloid-β through TFEB Activation.

Meng X, Luo Y, Liang T, Wang M, Zhao J, Sun G, Sun X.

J Alzheimers Dis. 2016 Apr 5;52(3):1135-50. doi: 10.3233/JAD-160096.

PMID:
27060963

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