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Items: 1 to 20 of 98

1.

ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.

Zhao Y, Sun X, Hu D, Prosdocimo DA, Hoppel C, Jain MK, Ramachandran R, Qi X.

Nat Commun. 2019 Mar 26;10(1):1371. doi: 10.1038/s41467-019-09291-x.

2.

Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington's disease.

Roe AJ, Qi X.

Biochem Biophys Res Commun. 2018 Feb 5;496(2):706-711. doi: 10.1016/j.bbrc.2018.01.114. Epub 2018 Jan 31.

3.

S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease.

Haun F, Nakamura T, Shiu AD, Cho DH, Tsunemi T, Holland EA, La Spada AR, Lipton SA.

Antioxid Redox Signal. 2013 Oct 10;19(11):1173-84. doi: 10.1089/ars.2012.4928. Epub 2013 Jun 20.

4.

Inhibition of Drp1 hyperactivation reduces neuropathology and behavioral deficits in zQ175 knock-in mouse model of Huntington's disease.

Zhao Y, Sun X, Qi X.

Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):319-323. doi: 10.1016/j.bbrc.2018.11.031. Epub 2018 Nov 16.

5.

Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.

Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X.

J Clin Invest. 2013 Dec;123(12):5371-88. doi: 10.1172/JCI70911. Epub 2013 Nov 15.

6.

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity.

Song W, Chen J, Petrilli A, Liot G, Klinglmayr E, Zhou Y, Poquiz P, Tjong J, Pouladi MA, Hayden MR, Masliah E, Ellisman M, Rouiller I, Schwarzenbacher R, Bossy B, Perkins G, Bossy-Wetzel E.

Nat Med. 2011 Mar;17(3):377-82. doi: 10.1038/nm.2313. Epub 2011 Feb 20.

7.

Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease.

Cherubini M, Puigdellívol M, Alberch J, Ginés S.

Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2145-60. doi: 10.1016/j.bbadis.2015.06.025. Epub 2015 Jul 2.

8.

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.

Shirendeb UP, Calkins MJ, Manczak M, Anekonda V, Dufour B, McBride JL, Mao P, Reddy PH.

Hum Mol Genet. 2012 Jan 15;21(2):406-20. doi: 10.1093/hmg/ddr475. Epub 2011 Oct 13.

9.

Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease.

Joshi AU, Ebert AE, Haileselassie B, Mochly-Rosen D.

J Mol Cell Cardiol. 2019 Feb;127:125-133. doi: 10.1016/j.yjmcc.2018.12.004. Epub 2018 Dec 11.

PMID:
30550751
10.

VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.

Guo X, Sun X, Hu D, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi AU, Luo Y, Mochly-Rosen D, Qi X.

Nat Commun. 2016 Aug 26;7:12646. doi: 10.1038/ncomms12646.

11.

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases.

Reddy PH, Reddy TP, Manczak M, Calkins MJ, Shirendeb U, Mao P.

Brain Res Rev. 2011 Jun 24;67(1-2):103-18. doi: 10.1016/j.brainresrev.2010.11.004. Epub 2010 Dec 8. Review.

12.

Removal of the Mitochondrial Fission Factor Mff Exacerbates Neuronal Loss and Neurological Phenotypes in a Huntington's Disease Mouse Model.

Cha MY, Chen H, Chan D.

PLoS Curr. 2018 Jul 26;10. pii: ecurrents.hd.a4e15b80c4915c828d39754942c6631f. doi: 10.1371/currents.hd.a4e15b80c4915c828d39754942c6631f.

13.

A threshold of transmembrane potential is required for mitochondrial dynamic balance mediated by DRP1 and OMA1.

Jones E, Gaytan N, Garcia I, Herrera A, Ramos M, Agarwala D, Rana M, Innis-Whitehouse W, Schuenzel E, Gilkerson R.

Cell Mol Life Sci. 2017 Apr;74(7):1347-1363. doi: 10.1007/s00018-016-2421-9. Epub 2016 Nov 17.

14.

S-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration.

Nakamura T, Cieplak P, Cho DH, Godzik A, Lipton SA.

Mitochondrion. 2010 Aug;10(5):573-8. doi: 10.1016/j.mito.2010.04.007. Epub 2010 May 4. Review.

15.

Mitochondrial diseases of the brain.

Chaturvedi RK, Flint Beal M.

Free Radic Biol Med. 2013 Oct;63:1-29. doi: 10.1016/j.freeradbiomed.2013.03.018. Epub 2013 Apr 6. Review.

PMID:
23567191
16.

Adhesion Regulating Molecule 1 Mediates HAP40 Overexpression-Induced Mitochondrial Defects.

Huang ZN, Chung HM, Fang SC, Her LS.

Int J Biol Sci. 2017 Nov 1;13(11):1420-1437. doi: 10.7150/ijbs.20742. eCollection 2017.

17.
18.

Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission.

Reddy PH.

Drug Discov Today. 2014 Jul;19(7):951-5. doi: 10.1016/j.drudis.2014.03.020. Epub 2014 Mar 28. Review.

19.

Amelioration of ischemic mitochondrial injury and Bax-dependent outer membrane permeabilization by Mdivi-1.

Zhao YX, Cui M, Chen SF, Dong Q, Liu XY.

CNS Neurosci Ther. 2014 Jun;20(6):528-38. doi: 10.1111/cns.12266. Epub 2014 Apr 8.

PMID:
24712408
20.

Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease.

Yan J, Liu XH, Han MZ, Wang YM, Sun XL, Yu N, Li T, Su B, Chen ZY.

Neurobiol Aging. 2015 Jan;36(1):211-27. doi: 10.1016/j.neurobiolaging.2014.08.005. Epub 2014 Aug 8.

PMID:
25192600

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