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Items: 1 to 20 of 108

1.

Histochemical Analysis of Glaucoma Caused by a Myocilin Mutation in a Human Donor Eye.

van der Heide CJ, Alward WLM, Flamme-Wiese M, Riker M, Syed NA, Anderson MG, Carter K, Kuehn MH, Stone EM, Mullins RF, Fingert JH.

Ophthalmol Glaucoma. 2018 Sep-Oct;1(2):132-138. doi: 10.1016/j.ogla.2018.08.004. Epub 2018 Aug 17.

PMID:
30906929
2.

Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork.

Kasetti RB, Phan TN, Millar JC, Zode GS.

Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6058-6069. doi: 10.1167/iovs.16-19610.

3.

Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma.

Zode GS, Kuehn MH, Nishimura DY, Searby CC, Mohan K, Grozdanic SD, Bugge K, Anderson MG, Clark AF, Stone EM, Sheffield VC.

J Clin Invest. 2011 Sep;121(9):3542-53. doi: 10.1172/JCI58183. Epub 2011 Aug 8. Erratum in: J Clin Invest. 2015 Aug 3;125(8):3303.

4.

Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma.

Zode GS, Bugge KE, Mohan K, Grozdanic SD, Peters JC, Koehn DR, Anderson MG, Kardon RH, Stone EM, Sheffield VC.

Invest Ophthalmol Vis Sci. 2012 Mar 21;53(3):1557-65. doi: 10.1167/iovs.11-8837. Print 2012 Mar.

5.

Gene expression profile in human trabecular meshwork from patients with primary open-angle glaucoma.

Liu Y, Allingham RR, Qin X, Layfield D, Dellinger AE, Gibson J, Wheeler J, Ashley-Koch AE, Stamer WD, Hauser MA.

Invest Ophthalmol Vis Sci. 2013 Sep 27;54(9):6382-9. doi: 10.1167/iovs.13-12128.

6.

A review of genetic and structural understanding of the role of myocilin in primary open angle glaucoma.

Kanagavalli J, Pandaranayaka E, Krishnadas SR, Krishnaswamy S, Sundaresan P.

Indian J Ophthalmol. 2004 Dec;52(4):271-80. Review.

7.

Immunohistochemical localization of MYOC/TIGR protein in the trabecular tissue of normal and glaucomatous eyes.

Tawara A, Okada Y, Kubota T, Suzuki Y, Taniguchi F, Shirato S, Nguyen TD, Ohnishi Y.

Curr Eye Res. 2000 Dec;21(6):934-43.

PMID:
11262617
8.

Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor.

Jacobson N, Andrews M, Shepard AR, Nishimura D, Searby C, Fingert JH, Hageman G, Mullins R, Davidson BL, Kwon YH, Alward WL, Stone EM, Clark AF, Sheffield VC.

Hum Mol Genet. 2001 Jan 15;10(2):117-25.

PMID:
11152659
9.
10.

Correction of the disease phenotype of myocilin-causing glaucoma by a natural osmolyte.

Jia LY, Gong B, Pang CP, Huang Y, Lam DS, Wang N, Yam GH.

Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3743-9. doi: 10.1167/iovs.08-3151. Epub 2009 Feb 21.

PMID:
19234343
11.

Intracellular sequestration of hetero-oligomers formed by wild-type and glaucoma-causing myocilin mutants.

Gobeil S, Rodrigue MA, Moisan S, Nguyen TD, Polansky JR, Morissette J, Raymond V.

Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3560-7.

PMID:
15452063
12.

The novel heterozygous Thr377Arg MYOC mutation causes severe Juvenile Open Angle Glaucoma in a large Pakistani family.

Waryah AM, Narsani AK, Sheikh SA, Shaikh H, Shahani MY.

Gene. 2013 Oct 10;528(2):356-9. doi: 10.1016/j.gene.2013.07.016. Epub 2013 Jul 23.

PMID:
23886590
13.

Myocilin in the trabecular meshwork of eyes with primary open-angle glaucoma.

Konz DD, Flügel-Koch C, Ohlmann A, Tamm ER.

Graefes Arch Clin Exp Ophthalmol. 2009 Dec;247(12):1643-9. doi: 10.1007/s00417-009-1152-0. Epub 2009 Aug 7.

PMID:
19662433
14.

Novel myocilin mutation in a Chinese family with juvenile-onset open-angle glaucoma.

Fan BJ, Leung DY, Wang DY, Gobeil S, Raymond V, Tam PO, Lam DS, Pang CP.

Arch Ophthalmol. 2006 Jan;124(1):102-6.

PMID:
16401791
15.

Overexpression and properties of wild-type and Tyr437His mutated myocilin in the eyes of transgenic mice.

Zillig M, Wurm A, Grehn FJ, Russell P, Tamm ER.

Invest Ophthalmol Vis Sci. 2005 Jan;46(1):223-34.

PMID:
15623777
16.

RNA interference as a gene silencing therapy for mutant MYOC protein in primary open angle glaucoma.

Li M, Xu J, Chen X, Sun X.

Diagn Pathol. 2009 Dec 16;4:46. doi: 10.1186/1746-1596-4-46.

17.

Cystatin a, a potential common link for mutant myocilin causative glaucoma.

Kennedy KD, AnithaChristy SA, Buie LK, Borrás T.

PLoS One. 2012;7(5):e36301. doi: 10.1371/journal.pone.0036301. Epub 2012 May 15.

18.

The myocilin (MYOC) gene expression in the human trabecular meshwork.

Takahashi H, Noda S, Mashima Y, Kubota R, Ohtake Y, Tanino T, Kudoh J, Minoshima S, Oguchi Y, Shimizu N.

Curr Eye Res. 2000 Feb;20(2):81-4.

PMID:
10617907
19.

MYOC gene mutations in Spanish patients with autosomal dominant primary open-angle glaucoma: a founder effect in southeast Spain.

Campos-Mollo E, Sánchez-Sánchez F, López-Garrido MP, López-Sánchez E, López-Martínez F, Escribano J.

Mol Vis. 2007 Sep 13;13:1666-73.

PMID:
17893668
20.

Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: implications for glaucoma.

Carbone MA, Ayroles JF, Yamamoto A, Morozova TV, West SA, Magwire MM, Mackay TF, Anholt RR.

PLoS One. 2009;4(1):e4216. doi: 10.1371/journal.pone.0004216. Epub 2009 Jan 16.

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