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Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington's disease: Activation of the Nrf2 pathway through lysophosphatidic acid receptors.

Jang M, Choi JH, Chang Y, Lee SJ, Nah SY, Cho IH.

Brain Behav Immun. 2019 Mar 7. pii: S0889-1591(18)30392-1. doi: 10.1016/j.bbi.2019.03.001. [Epub ahead of print]


Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-κB Pathways.

Jang M, Cho IH.

Mol Neurobiol. 2016 May;53(4):2619-35. doi: 10.1007/s12035-015-9230-2. Epub 2015 Jun 23.


Schisandra chinensis Stem Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity via Activation of the Nrf2 Pathway and Inhibition of the MAPKs and NF-κB Pathways.

Kim EJ, Jang M, Lee MJ, Choi JH, Lee SJ, Kim SK, Jang DS, Cho IH.

Front Pharmacol. 2017 Sep 29;8:673. doi: 10.3389/fphar.2017.00673. eCollection 2017.


Ethyl pyruvate ameliorates 3-nitropropionic acid-induced striatal toxicity through anti-neuronal cell death and anti-inflammatory mechanisms.

Jang M, Lee MJ, Cho IH.

Brain Behav Immun. 2014 May;38:151-65. doi: 10.1016/j.bbi.2014.01.015. Epub 2014 Feb 25.


Multi-Target Protective Effects of Gintonin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Mediated Model of Parkinson's Disease via Lysophosphatidic Acid Receptors.

Choi JH, Jang M, Oh S, Nah SY, Cho IH.

Front Pharmacol. 2018 May 23;9:515. doi: 10.3389/fphar.2018.00515. eCollection 2018.


Korean Red Ginseng Extract Attenuates 3-Nitropropionic Acid-Induced Huntington's-Like Symptoms.

Jang M, Lee MJ, Kim CS, Cho IH.

Evid Based Complement Alternat Med. 2013;2013:237207. doi: 10.1155/2013/237207. Epub 2013 Jan 27.


Synaptic enhancement induced by gintonin via lysophosphatidic acid receptor activation in central synapses.

Park H, Kim S, Rhee J, Kim HJ, Han JS, Nah SY, Chung C.

J Neurophysiol. 2015 Mar 1;113(5):1493-500. doi: 10.1152/jn.00667.2014. Epub 2014 Dec 10.


Gintonin, a ginseng-derived novel ingredient, evokes long-term potentiation through N-methyl-D-aspartic acid receptor activation: involvement of LPA receptors.

Shin TJ, Kim HJ, Kwon BJ, Choi SH, Kim HB, Hwang SH, Lee BH, Lee SM, Zukin RS, Park JH, Kim HC, Rhim H, Lee JH, Nah SY.

Mol Cells. 2012 Dec;34(6):563-72. doi: 10.1007/s10059-012-0254-4. Epub 2012 Nov 15.


Gintonin, a novel ginseng-derived lysophosphatidic acid receptor ligand, stimulates neurotransmitter release.

Hwang SH, Lee BH, Choi SH, Kim HJ, Jung SW, Kim HS, Shin HC, Park HJ, Park KH, Lee MK, Nah SY.

Neurosci Lett. 2015 Jan 1;584:356-61. doi: 10.1016/j.neulet.2014.11.007. Epub 2014 Nov 11.


Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease.

Chaturvedi RK, Hennessey T, Johri A, Tiwari SK, Mishra D, Agarwal S, Kim YS, Beal MF.

Hum Mol Genet. 2012 Aug 1;21(15):3474-88. doi: 10.1093/hmg/dds178. Epub 2012 May 15.


Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease.

Jin J, Albertz J, Guo Z, Peng Q, Rudow G, Troncoso JC, Ross CA, Duan W.

J Neurochem. 2013 May;125(3):410-9. doi: 10.1111/jnc.12190. Epub 2013 Mar 5.


Activation of lysophosphatidic acid receptor by gintonin inhibits Kv1.2 channel activity: involvement of tyrosine kinase and receptor protein tyrosine phosphatase α.

Lee JH, Choi SH, Lee BH, Hwang SH, Kim HJ, Rhee J, Chung C, Nah SY.

Neurosci Lett. 2013 Aug 26;548:143-8. doi: 10.1016/j.neulet.2013.05.048. Epub 2013 Jun 12.


Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.

Hwang SH, Shin EJ, Shin TJ, Lee BH, Choi SH, Kang J, Kim HJ, Kwon SH, Jang CG, Lee JH, Kim HC, Nah SY.

J Alzheimers Dis. 2012;31(1):207-23. doi: 10.3233/JAD-2012-120439.


AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease.

Franich NR, Fitzsimons HL, Fong DM, Klugmann M, During MJ, Young D.

Mol Ther. 2008 May;16(5):947-56. doi: 10.1038/mt.2008.50. Epub 2008 Mar 25.


Gintonin enhances performance of mice in rotarod test: Involvement of lysophosphatidic acid receptors and catecholamine release.

Lee BH, Kim J, Lee RM, Choi SH, Kim HJ, Hwang SH, Lee MK, Bae CS, Kim HC, Rhim H, Lim K, Nah SY.

Neurosci Lett. 2016 Jan 26;612:256-260. doi: 10.1016/j.neulet.2015.12.026. Epub 2015 Dec 17.


Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, potentiates ATP-gated P2X₁ receptor channel currents.

Choi SH, Kim HJ, Kim BR, Shin TJ, Hwang SH, Lee BH, Lee SM, Rhim H, Nah SY.

Mol Cells. 2013 Feb;35(2):142-50. doi: 10.1007/s10059-013-2293-x. Epub 2013 Feb 21.


Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity.

Hwang SH, Shin TJ, Choi SH, Cho HJ, Lee BH, Pyo MK, Lee JH, Kang J, Kim HJ, Park CW, Shin HC, Nah SY.

Mol Cells. 2012 Feb;33(2):151-62. doi: 10.1007/s10059-012-2216-z.

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