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Items: 1 to 20 of 101

1.
2.
3.

The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species.

Nemeria NS, Gerfen G, Nareddy PR, Yang L, Zhang X, Szostak M, Jordan F.

Free Radic Biol Med. 2018 Feb 1;115:136-145. doi: 10.1016/j.freeradbiomed.2017.11.018. Epub 2017 Dec 1.

PMID:
29191460
4.

Production of superoxide/hydrogen peroxide by the mitochondrial 2-oxoadipate dehydrogenase complex.

Goncalves RL, Bunik VI, Brand MD.

Free Radic Biol Med. 2016 Feb;91:247-55. doi: 10.1016/j.freeradbiomed.2015.12.020. Epub 2015 Dec 18.

5.

The human Krebs cycle 2-oxoglutarate dehydrogenase complex creates an additional source of superoxide/hydrogen peroxide from 2-oxoadipate as alternative substrate.

Nemeria NS, Gerfen G, Guevara E, Nareddy PR, Szostak M, Jordan F.

Free Radic Biol Med. 2017 Jul;108:644-654. doi: 10.1016/j.freeradbiomed.2017.04.017. Epub 2017 Apr 21.

PMID:
28435050
6.

DHTKD1 mutations cause 2-aminoadipic and 2-oxoadipic aciduria.

Danhauser K, Sauer SW, Haack TB, Wieland T, Staufner C, Graf E, Zschocke J, Strom TM, Traub T, Okun JG, Meitinger T, Hoffmann GF, Prokisch H, Kölker S.

Am J Hum Genet. 2012 Dec 7;91(6):1082-7. doi: 10.1016/j.ajhg.2012.10.006. Epub 2012 Nov 8.

7.

DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice.

Xu WY, Zhu H, Shen Y, Wan YH, Tu XD, Wu WT, Tang L, Zhang HX, Lu SY, Jin XL, Fei J, Wang ZG.

Mol Cell Biol. 2018 Jun 14;38(13). pii: e00085-18. doi: 10.1128/MCB.00085-18. Print 2018 Jul 1.

8.

A multipronged approach unravels unprecedented protein-protein interactions in the human 2-oxoglutarate dehydrogenase multienzyme complex.

Zhou J, Yang L, Ozohanics O, Zhang X, Wang J, Ambrus A, Arjunan P, Brukh R, Nemeria NS, Furey W, Jordan F.

J Biol Chem. 2018 Dec 14;293(50):19213-19227. doi: 10.1074/jbc.RA118.005432. Epub 2018 Oct 15.

PMID:
30323066
9.

Sources of superoxide/H2O2 during mitochondrial proline oxidation.

Goncalves RL, Rothschild DE, Quinlan CL, Scott GK, Benz CC, Brand MD.

Redox Biol. 2014 Jul 18;2:901-9. doi: 10.1016/j.redox.2014.07.003. eCollection 2014.

10.

Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis.

Sherrill JD, Kc K, Wang X, Wen T, Chamberlin A, Stucke EM, Collins MH, Abonia JP, Peng Y, Wu Q, Putnam PE, Dexheimer PJ, Aronow BJ, Kottyan LC, Kaufman KM, Harley JB, Huang T, Rothenberg ME.

JCI Insight. 2018 Apr 19;3(8). pii: 99922. doi: 10.1172/jci.insight.99922. eCollection 2018 Apr 19.

11.

Formation of reactive oxygen species by human and bacterial pyruvate and 2-oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components.

Ambrus A, Nemeria NS, Torocsik B, Tretter L, Nilsson M, Jordan F, Adam-Vizi V.

Free Radic Biol Med. 2015 Dec;89:642-50. doi: 10.1016/j.freeradbiomed.2015.10.001. Epub 2015 Oct 9.

12.

Generation of superoxide and hydrogen peroxide by side reactions of mitochondrial 2-oxoacid dehydrogenase complexes in isolation and in cells.

Bunik VI, Brand MD.

Biol Chem. 2018 Apr 25;399(5):407-420. doi: 10.1515/hsz-2017-0284. Review.

PMID:
29337692
13.

The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I.

Quinlan CL, Goncalves RL, Hey-Mogensen M, Yadava N, Bunik VI, Brand MD.

J Biol Chem. 2014 Mar 21;289(12):8312-25. doi: 10.1074/jbc.M113.545301. Epub 2014 Feb 10.

15.

Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate.

Nemeria NS, Ambrus A, Patel H, Gerfen G, Adam-Vizi V, Tretter L, Zhou J, Wang J, Jordan F.

J Biol Chem. 2014 Oct 24;289(43):29859-73. doi: 10.1074/jbc.M114.591073. Epub 2014 Sep 10.

16.

Elevated glutaric acid levels in Dhtkd1-/Gcdh- double knockout mice challenge our current understanding of lysine metabolism.

Biagosch C, Ediga RD, Hensler SV, Faerberboeck M, Kuehn R, Wurst W, Meitinger T, Kölker S, Sauer S, Prokisch H.

Biochim Biophys Acta Mol Basis Dis. 2017 Sep;1863(9):2220-2228. doi: 10.1016/j.bbadis.2017.05.018. Epub 2017 May 22.

17.

A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree.

Xu WY, Gu MM, Sun LH, Guo WT, Zhu HB, Ma JF, Yuan WT, Kuang Y, Ji BJ, Wu XL, Chen Y, Zhang HX, Sun FT, Huang W, Huang L, Chen SD, Wang ZG.

Am J Hum Genet. 2012 Dec 7;91(6):1088-94. doi: 10.1016/j.ajhg.2012.09.018. Epub 2012 Nov 8.

18.

Genetic basis of alpha-aminoadipic and alpha-ketoadipic aciduria.

Hagen J, te Brinke H, Wanders RJ, Knegt AC, Oussoren E, Hoogeboom AJ, Ruijter GJ, Becker D, Schwab KO, Franke I, Duran M, Waterham HR, Sass JO, Houten SM.

J Inherit Metab Dis. 2015 Sep;38(5):873-9. doi: 10.1007/s10545-015-9841-9. Epub 2015 Apr 10.

PMID:
25860818
19.

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling.

Brand MD.

Free Radic Biol Med. 2016 Nov;100:14-31. doi: 10.1016/j.freeradbiomed.2016.04.001. Epub 2016 Apr 13. Review.

PMID:
27085844
20.

Pinocembrin Suppresses H2O2-Induced Mitochondrial Dysfunction by a Mechanism Dependent on the Nrf2/HO-1 Axis in SH-SY5Y Cells.

de Oliveira MR, da Costa Ferreira G, Brasil FB, Peres A.

Mol Neurobiol. 2018 Feb;55(2):989-1003. doi: 10.1007/s12035-016-0380-7. Epub 2017 Jan 13.

PMID:
28084593

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