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Items: 1 to 20 of 103


Altered Regulation of Striatal Neuronal N-Methyl-D-Aspartate Receptor Trafficking by Palmitoylation in Huntington Disease Mouse Model.

Kang R, Wang L, Sanders SS, Zuo K, Hayden MR, Raymond LA.

Front Synaptic Neurosci. 2019 Feb 21;11:3. doi: 10.3389/fnsyn.2019.00003. eCollection 2019.


Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.

Sutton LM, Sanders SS, Butland SL, Singaraja RR, Franciosi S, Southwell AL, Doty CN, Schmidt ME, Mui KK, Kovalik V, Young FB, Zhang W, Hayden MR.

Hum Mol Genet. 2013 Feb 1;22(3):452-65. doi: 10.1093/hmg/dds441. Epub 2012 Oct 16.


Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model.

Gladding CM, Sepers MD, Xu J, Zhang LY, Milnerwood AJ, Lombroso PJ, Raymond LA.

Hum Mol Genet. 2012 Sep 1;21(17):3739-52. doi: 10.1093/hmg/dds154. Epub 2012 Apr 20.


Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development.

Sanders SS, Hou J, Sutton LM, Garside VC, Mui KK, Singaraja RR, Hayden MR, Hoodless PA.

Dev Biol. 2015 Jan 15;397(2):257-66. doi: 10.1016/j.ydbio.2014.11.018. Epub 2014 Dec 3.


P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease.

Fan J, Gladding CM, Wang L, Zhang LY, Kaufman AM, Milnerwood AJ, Raymond LA.

Neurobiol Dis. 2012 Mar;45(3):999-1009. doi: 10.1016/j.nbd.2011.12.019. Epub 2011 Dec 14.


Aberrant palmitoylation in Huntington disease.

Sanders SS, Hayden MR.

Biochem Soc Trans. 2015 Apr;43(2):205-10. doi: 10.1042/BST20140242. Review.


Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice.

Milnerwood AJ, Kaufman AM, Sepers MD, Gladding CM, Zhang L, Wang L, Fan J, Coquinco A, Qiao JY, Lee H, Wang YT, Cynader M, Raymond LA.

Neurobiol Dis. 2012 Oct;48(1):40-51. doi: 10.1016/j.nbd.2012.05.013. Epub 2012 Jun 2.


Identification of binding sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14L.

Sanders SS, Mui KK, Sutton LM, Hayden MR.

PLoS One. 2014 Feb 28;9(2):e90669. doi: 10.1371/journal.pone.0090669. eCollection 2014.


Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.

Huang K, Sanders SS, Kang R, Carroll JB, Sutton L, Wan J, Singaraja R, Young FB, Liu L, El-Husseini A, Davis NG, Hayden MR.

Hum Mol Genet. 2011 Sep 1;20(17):3356-65. doi: 10.1093/hmg/ddr242. Epub 2011 Jun 2.


Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport.

Goytain A, Hines RM, Quamme GA.

J Biol Chem. 2008 Nov 28;283(48):33365-74. doi: 10.1074/jbc.M801469200. Epub 2008 Sep 15.


Putting proteins in their place: palmitoylation in Huntington disease and other neuropsychiatric diseases.

Young FB, Butland SL, Sanders SS, Sutton LM, Hayden MR.

Prog Neurobiol. 2012 May;97(2):220-38. doi: 10.1016/j.pneurobio.2011.11.002. Epub 2011 Dec 7. Review.


Chronic blockade of extrasynaptic NMDA receptors ameliorates synaptic dysfunction and pro-death signaling in Huntington disease transgenic mice.

Dau A, Gladding CM, Sepers MD, Raymond LA.

Neurobiol Dis. 2014 Feb;62:533-42. doi: 10.1016/j.nbd.2013.11.013. Epub 2013 Nov 19.


Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity.

Cowan CM, Fan MM, Fan J, Shehadeh J, Zhang LY, Graham RK, Hayden MR, Raymond LA.

J Neurosci. 2008 Nov 26;28(48):12725-35. doi: 10.1523/JNEUROSCI.4619-08.2008.


Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

Singaraja RR, Huang K, Sanders SS, Milnerwood AJ, Hines R, Lerch JP, Franciosi S, Drisdel RC, Vaid K, Young FB, Doty C, Wan J, Bissada N, Henkelman RM, Green WN, Davis NG, Raymond LA, Hayden MR.

Hum Mol Genet. 2011 Oct 15;20(20):3899-909. doi: 10.1093/hmg/ddr308. Epub 2011 Jul 20.


Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model.

Gladding CM, Fan J, Zhang LY, Wang L, Xu J, Li EH, Lombroso PJ, Raymond LA.

J Neurochem. 2014 Jul;130(1):145-59. doi: 10.1111/jnc.12700. Epub 2014 Apr 2.


Differential changes in thalamic and cortical excitatory synapses onto striatal spiny projection neurons in a Huntington disease mouse model.

Kolodziejczyk K, Raymond LA.

Neurobiol Dis. 2016 Feb;86:62-74. doi: 10.1016/j.nbd.2015.11.020. Epub 2015 Nov 24.


Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.

Zhang H, Li Q, Graham RK, Slow E, Hayden MR, Bezprozvanny I.

Neurobiol Dis. 2008 Jul;31(1):80-8. doi: 10.1016/j.nbd.2008.03.010. Epub 2008 Apr 16.


Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.

Yanai A, Huang K, Kang R, Singaraja RR, Arstikaitis P, Gan L, Orban PC, Mullard A, Cowan CM, Raymond LA, Drisdel RC, Green WN, Ravikumar B, Rubinsztein DC, El-Husseini A, Hayden MR.

Nat Neurosci. 2006 Jun;9(6):824-31. Epub 2006 May 14.


Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity.

Huang K, Sanders S, Singaraja R, Orban P, Cijsouw T, Arstikaitis P, Yanai A, Hayden MR, El-Husseini A.

FASEB J. 2009 Aug;23(8):2605-15. doi: 10.1096/fj.08-127399. Epub 2009 Mar 19.


Dysregulated striatal neuronal processing and impaired motor behavior in mice lacking huntingtin interacting protein 14 (HIP14).

Estrada-Sánchez AM, Barton SJ, Burroughs CL, Doyle AR, Rebec GV.

PLoS One. 2013 Dec 23;8(12):e84537. doi: 10.1371/journal.pone.0084537. eCollection 2013.

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