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Items: 1 to 20 of 99

1.

A small-molecule fusion inhibitor of influenza virus is orally active in mice.

van Dongen MJP, Kadam RU, Juraszek J, Lawson E, Brandenburg B, Schmitz F, Schepens WBG, Stoops B, van Diepen HA, Jongeneelen M, Tang C, Vermond J, van Eijgen-Obregoso Real A, Blokland S, Garg D, Yu W, Goutier W, Lanckacker E, Klap JM, Peeters DCG, Wu J, Buyck C, Jonckers THM, Roymans D, Roevens P, Vogels R, Koudstaal W, Friesen RHE, Raboisson P, Dhanak D, Goudsmit J, Wilson IA.

Science. 2019 Mar 8;363(6431). pii: eaar6221. doi: 10.1126/science.aar6221.

2.

In Vitro Neutralization Is Not Predictive of Prophylactic Efficacy of Broadly Neutralizing Monoclonal Antibodies CR6261 and CR9114 against Lethal H2 Influenza Virus Challenge in Mice.

Sutton TC, Lamirande EW, Bock KW, Moore IN, Koudstaal W, Rehman M, Weverling GJ, Goudsmit J, Subbarao K.

J Virol. 2017 Nov 30;91(24). pii: e01603-17. doi: 10.1128/JVI.01603-17. Print 2017 Dec 15.

3.

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen.

Impagliazzo A, Milder F, Kuipers H, Wagner MV, Zhu X, Hoffman RM, van Meersbergen R, Huizingh J, Wanningen P, Verspuij J, de Man M, Ding Z, Apetri A, Kükrer B, Sneekes-Vriese E, Tomkiewicz D, Laursen NS, Lee PS, Zakrzewska A, Dekking L, Tolboom J, Tettero L, van Meerten S, Yu W, Koudstaal W, Goudsmit J, Ward AB, Meijberg W, Wilson IA, Radošević K.

Science. 2015 Sep 18;349(6254):1301-6. doi: 10.1126/science.aac7263. Epub 2015 Aug 24.

4.

Vaccine-induced anti-HA2 antibodies promote virus fusion and enhance influenza virus respiratory disease.

Khurana S, Loving CL, Manischewitz J, King LR, Gauger PC, Henningson J, Vincent AL, Golding H.

Sci Transl Med. 2013 Aug 28;5(200):200ra114. doi: 10.1126/scitranslmed.3006366.

5.

A Bivalent Heterologous DNA Virus-Like-Particle Prime-Boost Vaccine Elicits Broad Protection against both Group 1 and 2 Influenza A Viruses.

Jiang W, Wang S, Chen H, Ren H, Huang X, Wang G, Chen Z, Chen L, Chen Z, Zhou P.

J Virol. 2017 Apr 13;91(9). pii: e02052-16. doi: 10.1128/JVI.02052-16. Print 2017 May 1.

6.

Characterization of potent fusion inhibitors of influenza virus.

Rowse M, Qiu S, Tsao J, Xian T, Khawaja S, Yamauchi Y, Yang Z, Wang G, Luo M.

PLoS One. 2015 Mar 24;10(3):e0122536. doi: 10.1371/journal.pone.0122536. eCollection 2015.

7.

Targeting the HA2 subunit of influenza A virus hemagglutinin via CD40L provides universal protection against diverse subtypes.

Fan X, Hashem AM, Chen Z, Li C, Doyle T, Zhang Y, Yi Y, Farnsworth A, Xu K, Li Z, He R, Li X, Wang J.

Mucosal Immunol. 2015 Jan;8(1):211-20. doi: 10.1038/mi.2014.59. Epub 2014 Jul 23.

8.

Conformational Stability of the Hemagglutinin of H5N1 Influenza A Viruses Influences Susceptibility to Broadly Neutralizing Stem Antibodies.

Wang W, Song HS, Keller PW, Alvarado-Facundo E, Vassell R, Weiss CD.

J Virol. 2018 May 29;92(12). pii: e00247-18. doi: 10.1128/JVI.00247-18. Print 2018 Jun 15.

9.

A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses.

Shen C, Chen J, Li R, Zhang M, Wang G, Stegalkina S, Zhang L, Chen J, Cao J, Bi X, Anderson SF, Alefantis T, Zhang M, Cai X, Yang K, Zheng Q, Fang M, Yu H, Luo W, Zheng Z, Yuan Q, Zhang J, Wai-Kuo Shih J, Kleanthous H, Chen H, Chen Y, Xia N.

Sci Transl Med. 2017 Oct 18;9(412). pii: eaam5752. doi: 10.1126/scitranslmed.aam5752.

PMID:
29046433
10.

Intermonomer Interactions in Hemagglutinin Subunits HA1 and HA2 Affecting Hemagglutinin Stability and Influenza Virus Infectivity.

Wang W, DeFeo CJ, Alvarado-Facundo E, Vassell R, Weiss CD.

J Virol. 2015 Oct;89(20):10602-11. doi: 10.1128/JVI.00939-15. Epub 2015 Aug 12.

11.

Relating influenza virus membrane fusion kinetics to stoichiometry of neutralizing antibodies at the single-particle level.

Otterstrom JJ, Brandenburg B, Koldijk MH, Juraszek J, Tang C, Mashaghi S, Kwaks T, Goudsmit J, Vogels R, Friesen RH, van Oijen AM.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):E5143-8. doi: 10.1073/pnas.1411755111. Epub 2014 Nov 17.

12.

Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages.

Corbett KS, Moin SM, Yassine HM, Cagigi A, Kanekiyo M, Boyoglu-Barnum S, Myers SI, Tsybovsky Y, Wheatley AK, Schramm CA, Gillespie RA, Shi W, Wang L, Zhang Y, Andrews SF, Joyce MG, Crank MC, Douek DC, McDermott AB, Mascola JR, Graham BS, Boyington JC.

MBio. 2019 Feb 26;10(1). pii: e02810-18. doi: 10.1128/mBio.02810-18.

13.

Unmasking Stem-Specific Neutralizing Epitopes by Abolishing N-Linked Glycosylation Sites of Influenza Virus Hemagglutinin Proteins for Vaccine Design.

Liu WC, Jan JT, Huang YJ, Chen TH, Wu SC.

J Virol. 2016 Sep 12;90(19):8496-508. doi: 10.1128/JVI.00880-16. Print 2016 Oct 1.

14.

Entry Inhibition of Influenza Viruses with High Mannose Binding Lectin ESA-2 from the Red Alga Eucheuma serra through the Recognition of Viral Hemagglutinin.

Sato Y, Morimoto K, Kubo T, Sakaguchi T, Nishizono A, Hirayama M, Hori K.

Mar Drugs. 2015 May 29;13(6):3454-65. doi: 10.3390/md13063454.

15.

Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain.

Raymond DD, Stewart SM, Lee J, Ferdman J, Bajic G, Do KT, Ernandes MJ, Suphaphiphat P, Settembre EC, Dormitzer PR, Del Giudice G, Finco O, Kang TH, Ippolito GC, Georgiou G, Kepler TB, Haynes BF, Moody MA, Liao HX, Schmidt AG, Harrison SC.

Nat Med. 2016 Dec;22(12):1465-1469. doi: 10.1038/nm.4223. Epub 2016 Nov 7.

16.

Recurring and Adaptable Binding Motifs in Broadly Neutralizing Antibodies to Influenza Virus Are Encoded on the D3-9 Segment of the Ig Gene.

Wu NC, Yamayoshi S, Ito M, Uraki R, Kawaoka Y, Wilson IA.

Cell Host Microbe. 2018 Oct 10;24(4):569-578.e4. doi: 10.1016/j.chom.2018.09.010.

PMID:
30308159
17.

An oligothiophene compound neutralized influenza A viruses by interfering with hemagglutinin.

Shen X, Zhu Z, Ding Y, Wu W, Yang J, Liu S.

Biochim Biophys Acta Biomembr. 2018 Mar;1860(3):784-791. doi: 10.1016/j.bbamem.2017.12.006. Epub 2017 Dec 8.

18.

Potent peptidic fusion inhibitors of influenza virus.

Kadam RU, Juraszek J, Brandenburg B, Buyck C, Schepens WBG, Kesteleyn B, Stoops B, Vreeken RJ, Vermond J, Goutier W, Tang C, Vogels R, Friesen RHE, Goudsmit J, van Dongen MJP, Wilson IA.

Science. 2017 Oct 27;358(6362):496-502. doi: 10.1126/science.aan0516. Epub 2017 Sep 28.

19.

Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo.

DiLillo DJ, Tan GS, Palese P, Ravetch JV.

Nat Med. 2014 Feb;20(2):143-51. doi: 10.1038/nm.3443. Epub 2014 Jan 12.

20.

Heterosubtypic antiviral activity of hemagglutinin-specific antibodies induced by intranasal immunization with inactivated influenza viruses in mice.

Muramatsu M, Yoshida R, Miyamoto H, Tomabechi D, Kajihara M, Maruyama J, Kimura T, Manzoor R, Ito K, Takada A.

PLoS One. 2013 Aug 16;8(8):e71534. doi: 10.1371/journal.pone.0071534. eCollection 2013.

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