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Items: 1 to 20 of 101

1.

Design and characterization of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems.

Harding RJ, Loppnau P, Ackloo S, Lemak A, Hutchinson A, Hunt B, Holehouse AS, Ho JC, Fan L, Toledo-Sherman L, Seitova A, Arrowsmith CH.

J Biol Chem. 2019 Mar 6. pii: jbc.RA118.007204. doi: 10.1074/jbc.RA118.007204. [Epub ahead of print]

2.

Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin.

Huang B, Lucas T, Kueppers C, Dong X, Krause M, Bepperling A, Buchner J, Voshol H, Weiss A, Gerrits B, Kochanek S.

PLoS One. 2015 Mar 23;10(3):e0121055. doi: 10.1371/journal.pone.0121055. eCollection 2015.

4.

PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD).

Ratovitski T, Arbez N, Stewart JC, Chighladze E, Ross CA.

Cell Cycle. 2015;14(11):1716-29. doi: 10.1080/15384101.2015.1033595.

5.

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy.

Reif A, Chiki A, Ricci J, Lashuel HA.

J Vis Exp. 2018 Jun 27;(136). doi: 10.3791/57506.

7.

pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking.

Pardo R, Molina-Calavita M, Poizat G, Keryer G, Humbert S, Saudou F.

Mol Brain. 2010 Jun 1;3:17. doi: 10.1186/1756-6606-3-17.

8.

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.

Busch A, Engemann S, Lurz R, Okazawa H, Lehrach H, Wanker EE.

J Biol Chem. 2003 Oct 17;278(42):41452-61. Epub 2003 Jul 29.

9.

Biophysical Aspect of Huntingtin Protein During polyQ: An In Silico Insight.

Gopalakrishnan C, Jethi S, Kalsi N, Purohit R.

Cell Biochem Biophys. 2016 Jun;74(2):129-39. doi: 10.1007/s12013-016-0728-7. Epub 2016 Apr 19.

PMID:
27094178
10.

Huntington’s Disease Pathogenesis: Mechanisms and Pathways.

La Spada AR, Weydt P, Pineda VV.

In: Lo DC, Hughes RE, editors. Neurobiology of Huntington's Disease: Applications to Drug Discovery. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 2.

11.

The dynamics of early-state transcriptional changes and aggregate formation in a Huntington's disease cell model.

van Hagen M, Piebes DGE, de Leeuw WC, Vuist IM, van Roon-Mom WMC, Moerland PD, Verschure PJ.

BMC Genomics. 2017 May 12;18(1):373. doi: 10.1186/s12864-017-3745-z.

12.

Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype.

Wegrzynowicz M, Bichell TJ, Soares BD, Loth MK, McGlothan JS, Mori S, Alikhan FS, Hua K, Coughlin JM, Holt HK, Jetter CS, Pomper MG, Osmand AP, Guilarte TR, Bowman AB.

J Huntingtons Dis. 2015;4(1):17-36.

13.

The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.

Huang ZN, Her LS.

Mol Neurobiol. 2017 Nov;54(9):7382-7400. doi: 10.1007/s12035-016-0247-y. Epub 2016 Nov 5.

PMID:
27815841
14.

Effects of overexpression of huntingtin proteins on mitochondrial integrity.

Wang H, Lim PJ, Karbowski M, Monteiro MJ.

Hum Mol Genet. 2009 Feb 15;18(4):737-52. doi: 10.1093/hmg/ddn404. Epub 2008 Nov 27.

15.
16.

Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.

Bradford J, Shin JY, Roberts M, Wang CE, Sheng G, Li S, Li XJ.

J Biol Chem. 2010 Apr 2;285(14):10653-61. doi: 10.1074/jbc.M109.083287. Epub 2010 Feb 9.

17.

Modeling Huntington disease in Drosophila: Insights into axonal transport defects and modifiers of toxicity.

Krench M, Littleton JT.

Fly (Austin). 2013 Oct-Dec;7(4):229-36. doi: 10.4161/fly.26279. Epub 2013 Sep 10.

18.

Making (anti-) sense out of huntingtin levels in Huntington disease.

Evers MM, Schut MH, Pepers BA, Atalar M, van Belzen MJ, Faull RL, Roos RA, van Roon-Mom WM.

Mol Neurodegener. 2015 Apr 28;10:21. doi: 10.1186/s13024-015-0018-7.

19.

Cancer: From Wild-Type to Mutant Huntingtin.

Thion MS, Humbert S.

J Huntingtons Dis. 2018;7(3):201-208. doi: 10.3233/JHD-180290.

20.

The emerging role of the first 17 amino acids of huntingtin in Huntington's disease.

Arndt JR, Chaibva M, Legleiter J.

Biomol Concepts. 2015 Mar;6(1):33-46. doi: 10.1515/bmc-2015-0001. Review.

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