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Junctophilins emerge as novel therapeutic targets.

Jiang J, Tang M, Huang Z, Chen L.

J Cell Physiol. 2019 Mar 1. doi: 10.1002/jcp.28405. [Epub ahead of print] Review.


The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and is a modifier of a Huntingtin poly-Q expansion and the Notch pathway.

Calpena E, López Del Amo V, Chakraborty M, Llamusí B, Artero R, Espinós C, Galindo MI.

Dis Model Mech. 2018 Jan 17;11(1). pii: dmm029082. doi: 10.1242/dmm.029082.


The junctophilin family of proteins: from bench to bedside.

Landstrom AP, Beavers DL, Wehrens XH.

Trends Mol Med. 2014 Jun;20(6):353-62. doi: 10.1016/j.molmed.2014.02.004. Epub 2014 Mar 14. Review.


Ca²⁺ microdomains organized by junctophilins.

Takeshima H, Hoshijima M, Song LS.

Cell Calcium. 2015 Oct;58(4):349-56. doi: 10.1016/j.ceca.2015.01.007. Epub 2015 Jan 25. Review.


Junctophilin 1 and 2 proteins interact with the L-type Ca2+ channel dihydropyridine receptors (DHPRs) in skeletal muscle.

Golini L, Chouabe C, Berthier C, Cusimano V, Fornaro M, Bonvallet R, Formoso L, Giacomello E, Jacquemond V, Sorrentino V.

J Biol Chem. 2011 Dec 23;286(51):43717-25. doi: 10.1074/jbc.M111.292755. Epub 2011 Oct 21.


Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle.

Murphy RM, Dutka TL, Horvath D, Bell JR, Delbridge LM, Lamb GD.

J Physiol. 2013 Feb 1;591(3):719-29. doi: 10.1113/jphysiol.2012.243279. Epub 2012 Nov 12.


Physical interaction of junctophilin and the CaV1.1 C terminus is crucial for skeletal muscle contraction.

Nakada T, Kashihara T, Komatsu M, Kojima K, Takeshita T, Yamada M.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4507-4512. doi: 10.1073/pnas.1716649115. Epub 2018 Apr 9.


Important role of junctophilin in nematode motor function.

Yoshida M, Sugimoto A, Ohshima Y, Takeshima H.

Biochem Biophys Res Commun. 2001 Nov 23;289(1):234-9.


Deficiency of triad junction and contraction in mutant skeletal muscle lacking junctophilin type 1.

Ito K, Komazaki S, Sasamoto K, Yoshida M, Nishi M, Kitamura K, Takeshima H.

J Cell Biol. 2001 Sep 3;154(5):1059-67.


Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.

Kakizawa S, Kishimoto Y, Hashimoto K, Miyazaki T, Furutani K, Shimizu H, Fukaya M, Nishi M, Sakagami H, Ikeda A, Kondo H, Kano M, Watanabe M, Iino M, Takeshima H.

EMBO J. 2007 Apr 4;26(7):1924-33. Epub 2007 Mar 8.


Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2+ entry via Orai1.

Woo JS, Cho CH, Lee KJ, Kim DH, Ma J, Lee EH.

J Biol Chem. 2012 Apr 27;287(18):14336-48. doi: 10.1074/jbc.M111.304808. Epub 2012 Mar 2.


Motor discoordination in mutant mice lacking junctophilin type 3.

Nishi M, Hashimoto K, Kuriyama K, Komazaki S, Kano M, Shibata S, Takeshima H.

Biochem Biophys Res Commun. 2002 Mar 29;292(2):318-24.


Junctophilins: a novel family of junctional membrane complex proteins.

Takeshima H, Komazaki S, Nishi M, Iino M, Kangawa K.

Mol Cell. 2000 Jul;6(1):11-22.


Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins.

Moriguchi S, Nishi M, Komazaki S, Sakagami H, Miyazaki T, Masumiya H, Saito SY, Watanabe M, Kondo H, Yawo H, Fukunaga K, Takeshima H.

Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10811-6. Epub 2006 Jun 29.


Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions.

Kakizawa S, Moriguchi S, Ikeda A, Iino M, Takeshima H.

Cerebellum. 2008;7(3):385-91. doi: 10.1007/s12311-008-0040-1.


Ryanodine receptor and junctional membrane structure.

Takeshima H.

Nihon Yakurigaku Zasshi. 2003 Apr;121(4):203-10. doi: 10.1254/fpj.121.203. Review. Japanese.


Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans.

Landstrom AP, Weisleder N, Batalden KB, Bos JM, Tester DJ, Ommen SR, Wehrens XH, Claycomb WC, Ko JK, Hwang M, Pan Z, Ma J, Ackerman MJ.

J Mol Cell Cardiol. 2007 Jun;42(6):1026-35. Epub 2007 Apr 18.


Coexpression of junctophilin type 3 and type 4 in brain.

Nishi M, Sakagami H, Komazaki S, Kondo H, Takeshima H.

Brain Res Mol Brain Res. 2003 Oct 21;118(1-2):102-10.


S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle.

Woo JS, Hwang JH, Ko JK, Weisleder N, Kim DH, Ma J, Lee EH.

Biochem J. 2010 Mar 15;427(1):125-34. doi: 10.1042/BJ20091225.


New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.

Yamazaki D, Yamazaki T, Takeshima H.

Pharmacol Ther. 2009 Mar;121(3):265-72. doi: 10.1016/j.pharmthera.2008.11.004. Epub 2008 Dec 3. Review.


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