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Items: 1 to 20 of 101

1.

Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model.

Ionescu A, Gradus T, Altman T, Maimon R, Saraf Avraham N, Geva M, Hayden M, Perlson E.

Cell Death Dis. 2019 Mar 1;10(3):210. doi: 10.1038/s41419-019-1451-2.

2.

Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Clark JA, Southam KA, Blizzard CA, King AE, Dickson TC.

J Chem Neuroanat. 2016 Oct;76(Pt A):35-47. doi: 10.1016/j.jchemneu.2016.03.003. Epub 2016 Mar 30.

PMID:
27038603
3.

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.

Peviani M, Salvaneschi E, Bontempi L, Petese A, Manzo A, Rossi D, Salmona M, Collina S, Bigini P, Curti D.

Neurobiol Dis. 2014 Feb;62:218-32. doi: 10.1016/j.nbd.2013.10.010. Epub 2013 Oct 16.

PMID:
24141020
4.

Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex.

Thomsen GM, Gowing G, Latter J, Chen M, Vit JP, Staggenborg K, Avalos P, Alkaslasi M, Ferraiuolo L, Likhite S, Kaspar BK, Svendsen CN.

J Neurosci. 2014 Nov 19;34(47):15587-600. doi: 10.1523/JNEUROSCI.2037-14.2014.

5.

Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Milanese M, Giribaldi F, Melone M, Bonifacino T, Musante I, Carminati E, Rossi PI, Vergani L, Voci A, Conti F, Puliti A, Bonanno G.

Neurobiol Dis. 2014 Apr;64:48-59. doi: 10.1016/j.nbd.2013.11.006. Epub 2013 Dec 19.

6.

In-vivo effects of knocking-down metabotropic glutamate receptor 5 in the SOD1G93A mouse model of amyotrophic lateral sclerosis.

Bonifacino T, Cattaneo L, Gallia E, Puliti A, Melone M, Provenzano F, Bossi S, Musante I, Usai C, Conti F, Bonanno G, Milanese M.

Neuropharmacology. 2017 Sep 1;123:433-445. doi: 10.1016/j.neuropharm.2017.06.020. Epub 2017 Jun 21.

PMID:
28645622
7.

Epothilone D accelerates disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis.

Clark JA, Blizzard CA, Breslin MC, Yeaman EJ, Lee KM, Chuckowree JA, Dickson TC.

Neuropathol Appl Neurobiol. 2018 Oct;44(6):590-605. doi: 10.1111/nan.12473. Epub 2018 Mar 27.

PMID:
29380402
8.

Neuromuscular effects of G93A-SOD1 expression in zebrafish.

Sakowski SA, Lunn JS, Busta AS, Oh SS, Zamora-Berridi G, Palmer M, Rosenberg AA, Philip SG, Dowling JJ, Feldman EL.

Mol Neurodegener. 2012 Aug 31;7:44. doi: 10.1186/1750-1326-7-44.

9.

Treatment with an antibody directed against Nogo-A delays disease progression in the SOD1G93A mouse model of Amyotrophic lateral sclerosis.

Bros-Facer V, Krull D, Taylor A, Dick JR, Bates SA, Cleveland MS, Prinjha RK, Greensmith L.

Hum Mol Genet. 2014 Aug 15;23(16):4187-200. doi: 10.1093/hmg/ddu136. Epub 2014 Mar 25.

PMID:
24667415
10.

Lack of TNF-alpha receptor type 2 protects motor neurons in a cellular model of amyotrophic lateral sclerosis and in mutant SOD1 mice but does not affect disease progression.

Tortarolo M, Vallarola A, Lidonnici D, Battaglia E, Gensano F, Spaltro G, Fiordaliso F, Corbelli A, Garetto S, Martini E, Pasetto L, Kallikourdis M, Bonetto V, Bendotti C.

J Neurochem. 2015 Oct;135(1):109-24. doi: 10.1111/jnc.13154. Epub 2015 Jun 4.

11.

Altered development in GABA co-release shapes glycinergic synaptic currents in cultured spinal slices of the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Medelin M, Rancic V, Cellot G, Laishram J, Veeraraghavan P, Rossi C, Muzio L, Sivilotti L, Ballerini L.

J Physiol. 2016 Jul 1;594(13):3827-40. doi: 10.1113/JP272382. Epub 2016 May 27.

12.

RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue.

Vallarola A, Sironi F, Tortarolo M, Gatto N, De Gioia R, Pasetto L, De Paola M, Mariani A, Ghosh S, Watson R, Kalmes A, Bonetto V, Bendotti C.

J Neuroinflammation. 2018 Mar 1;15(1):65. doi: 10.1186/s12974-018-1101-0.

13.

Macrophage-mediated inflammation and glial response in the skeletal muscle of a rat model of familial amyotrophic lateral sclerosis (ALS).

Van Dyke JM, Smit-Oistad IM, Macrander C, Krakora D, Meyer MG, Suzuki M.

Exp Neurol. 2016 Mar;277:275-282. doi: 10.1016/j.expneurol.2016.01.008. Epub 2016 Jan 13.

14.

Mechanisms of Enhanced Phrenic Long-Term Facilitation in SOD1G93A Rats.

Nichols NL, Satriotomo I, Allen LL, Grebe AM, Mitchell GS.

J Neurosci. 2017 Jun 14;37(24):5834-5845. doi: 10.1523/JNEUROSCI.3680-16.2017. Epub 2017 May 12.

15.

Repurposing carbamazepine for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model.

Zhang JJ, Zhou QM, Chen S, Le WD.

CNS Neurosci Ther. 2018 Dec;24(12):1163-1174. doi: 10.1111/cns.12855. Epub 2018 Apr 14.

PMID:
29656576
16.

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease.

Ryskamp D, Wu J, Geva M, Kusko R, Grossman I, Hayden M, Bezprozvanny I.

Neurobiol Dis. 2017 Jan;97(Pt A):46-59. doi: 10.1016/j.nbd.2016.10.006. Epub 2016 Nov 3.

17.

Muscle-derived but not centrally derived transgene GDNF is neuroprotective in G93A-SOD1 mouse model of ALS.

Li W, Brakefield D, Pan Y, Hunter D, Myckatyn TM, Parsadanian A.

Exp Neurol. 2007 Feb;203(2):457-71. Epub 2006 Oct 10.

PMID:
17034790
18.

SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models.

Ono Y, Tanaka H, Takata M, Nagahara Y, Noda Y, Tsuruma K, Shimazawa M, Hozumi I, Hara H.

Neurosci Lett. 2014 Jan 24;559:174-8. doi: 10.1016/j.neulet.2013.12.005. Epub 2013 Dec 12.

PMID:
24334165
19.

Defective mitochondrial dynamics is an early event in skeletal muscle of an amyotrophic lateral sclerosis mouse model.

Luo G, Yi J, Ma C, Xiao Y, Yi F, Yu T, Zhou J.

PLoS One. 2013 Dec 6;8(12):e82112. doi: 10.1371/journal.pone.0082112. eCollection 2013.

20.

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice.

Wong M, Martin LJ.

Hum Mol Genet. 2010 Jun 1;19(11):2284-302. doi: 10.1093/hmg/ddq106. Epub 2010 Mar 10.

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