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Items: 1 to 20 of 102

1.

A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks.

Mukherjee S, Klaus C, Pricop-Jeckstadt M, Miller JA, Struebing FL.

Front Neurosci. 2019 Jan 24;13:2. doi: 10.3389/fnins.2019.00002. eCollection 2019.

2.

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.

Rangaraju S, Dammer EB, Raza SA, Rathakrishnan P, Xiao H, Gao T, Duong DM, Pennington MW, Lah JJ, Seyfried NT, Levey AI.

Mol Neurodegener. 2018 May 21;13(1):24. doi: 10.1186/s13024-018-0254-8.

3.

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis.

Holtman IR, Raj DD, Miller JA, Schaafsma W, Yin Z, Brouwer N, Wes PD, Möller T, Orre M, Kamphuis W, Hol EM, Boddeke EW, Eggen BJ.

Acta Neuropathol Commun. 2015 May 23;3:31. doi: 10.1186/s40478-015-0203-5.

4.

TREM2 triggers microglial density and age-related neuronal loss.

Linnartz-Gerlach B, Bodea LG, Klaus C, Ginolhac A, Halder R, Sinkkonen L, Walter J, Colonna M, Neumann H.

Glia. 2019 Mar;67(3):539-550. doi: 10.1002/glia.23563. Epub 2018 Dec 11.

PMID:
30548312
5.

Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.

Sekiya M, Wang M, Fujisaki N, Sakakibara Y, Quan X, Ehrlich ME, De Jager PL, Bennett DA, Schadt EE, Gandy S, Ando K, Zhang B, Iijima KM.

Genome Med. 2018 Mar 29;10(1):26. doi: 10.1186/s13073-018-0530-9.

6.

Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain.

Felsky D, Patrick E, Schneider JA, Mostafavi S, Gaiteri C, Patsopoulos N, Bennett DA, De Jager PL.

Mol Neurodegener. 2018 Jul 24;13(1):38. doi: 10.1186/s13024-018-0272-6.

7.

Insights into TREM2 biology by network analysis of human brain gene expression data.

Forabosco P, Ramasamy A, Trabzuni D, Walker R, Smith C, Bras J, Levine AP, Hardy J, Pocock JM, Guerreiro R, Weale ME, Ryten M.

Neurobiol Aging. 2013 Dec;34(12):2699-714. doi: 10.1016/j.neurobiolaging.2013.05.001. Epub 2013 Jul 12.

8.

Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.

Haure-Mirande JV, Audrain M, Fanutza T, Kim SH, Klein WL, Glabe C, Readhead B, Dudley JT, Blitzer RD, Wang M, Zhang B, Schadt EE, Gandy S, Ehrlich ME.

Acta Neuropathol. 2017 Nov;134(5):769-788. doi: 10.1007/s00401-017-1737-3. Epub 2017 Jun 13.

9.

Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes.

Mecca C, Giambanco I, Donato R, Arcuri C.

Int J Mol Sci. 2018 Jan 22;19(1). pii: E318. doi: 10.3390/ijms19010318. Review.

10.

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins.

Rangaraju S, Dammer EB, Raza SA, Gao T, Xiao H, Betarbet R, Duong DM, Webster JA, Hales CM, Lah JJ, Levey AI, Seyfried NT.

Mol Neurodegener. 2018 Jun 28;13(1):34. doi: 10.1186/s13024-018-0266-4.

11.

Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model.

Wang H, Li Y, Ryder JW, Hole JT, Ebert PJ, Airey DC, Qian HR, Logsdon B, Fisher A, Ahmed Z, Murray TK, Cavallini A, Bose S, Eastwood BJ, Collier DA, Dage JL, Miller BB, Merchant KM, O'Neill MJ, Demattos RB.

Mol Neurodegener. 2018 Dec 17;13(1):65. doi: 10.1186/s13024-018-0296-y.

12.

A core transcriptional signature of human microglia: Derivation and utility in describing region-dependent alterations associated with Alzheimer's disease.

Patir A, Shih B, McColl BW, Freeman TC.

Glia. 2019 Feb 13. doi: 10.1002/glia.23572. [Epub ahead of print]

PMID:
30758077
13.

Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models.

Burns TC, Li MD, Mehta S, Awad AJ, Morgan AA.

Eur J Pharmacol. 2015 Jul 15;759:101-17. doi: 10.1016/j.ejphar.2015.03.021. Epub 2015 Mar 23.

PMID:
25814260
14.

CXCR4 involvement in neurodegenerative diseases.

Bonham LW, Karch CM, Fan CC, Tan C, Geier EG, Wang Y, Wen N, Broce IJ, Li Y, Barkovich MJ, Ferrari R, Hardy J, Momeni P, Höglinger G, Müller U, Hess CP, Sugrue LP, Dillon WP, Schellenberg GD, Miller BL, Andreassen OA, Dale AM, Barkovich AJ, Yokoyama JS, Desikan RS; International FTD-Genomics Consortium (IFGC); International Parkinson’s Disease Genetics Consortium (IPDGC); International Genomics of Alzheimer’s Project (IGAP).

Transl Psychiatry. 2018 Apr 11;8(1):73. doi: 10.1038/s41398-017-0049-7.

15.

Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury.

Castranio EL, Mounier A, Wolfe CM, Nam KN, Fitz NF, Letronne F, Schug J, Koldamova R, Lefterov I.

Neurobiol Dis. 2017 Sep;105:1-14. doi: 10.1016/j.nbd.2017.05.006. Epub 2017 May 11.

16.

Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation.

Wong WT.

Front Cell Neurosci. 2013 Mar 13;7:22. doi: 10.3389/fncel.2013.00022. eCollection 2013.

17.

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging.

Plaza-Zabala A, Sierra-Torre V, Sierra A.

Int J Mol Sci. 2017 Mar 9;18(3). pii: E598. doi: 10.3390/ijms18030598. Review.

18.

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O.

Immunity. 2017 Sep 19;47(3):566-581.e9. doi: 10.1016/j.immuni.2017.08.008.

19.

Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders.

von Bernhardi R, Tichauer JE, Eugenín J.

J Neurochem. 2010 Mar;112(5):1099-114. doi: 10.1111/j.1471-4159.2009.06537.x. Epub 2009 Dec 10. Review.

20.

TMEM106B haplotypes have distinct gene expression patterns in aged brain.

Ren Y, van Blitterswijk M, Allen M, Carrasquillo MM, Reddy JS, Wang X, Beach TG, Dickson DW, Ertekin-Taner N, Asmann YW, Rademakers R.

Mol Neurodegener. 2018 Jul 3;13(1):35. doi: 10.1186/s13024-018-0268-2.

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