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Items: 1 to 20 of 100

1.

Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons.

Höllerhage M, Fussi N, Rösler TW, Wurst W, Behrends C, Höglinger GU.

Neuropharmacology. 2019 May 1;149:13-26. doi: 10.1016/j.neuropharm.2019.01.023. Epub 2019 Feb 4.

PMID:
30731136
2.

Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy.

Fussi N, Höllerhage M, Chakroun T, Nykänen NP, Rösler TW, Koeglsperger T, Wurst W, Behrends C, Höglinger GU.

Cell Death Dis. 2018 Jul 9;9(7):757. doi: 10.1038/s41419-018-0816-2.

3.

Trifluoperazine rescues human dopaminergic cells from wild-type α-synuclein-induced toxicity.

Höllerhage M, Goebel JN, de Andrade A, Hildebrandt T, Dolga A, Culmsee C, Oertel WH, Hengerer B, Höglinger GU.

Neurobiol Aging. 2014 Jul;35(7):1700-11. doi: 10.1016/j.neurobiolaging.2014.01.027. Epub 2014 Jan 28.

PMID:
24559643
4.

Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro: A new possible toxic mechanism contributing to Parkinson's disease.

Sala G, Marinig D, Riva C, Arosio A, Stefanoni G, Brighina L, Formenti M, Alberghina L, Colangelo AM, Ferrarese C.

Neurotoxicology. 2016 May;54:161-169. doi: 10.1016/j.neuro.2016.04.018. Epub 2016 Apr 28.

PMID:
27133439
5.

Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells.

Höllerhage M, Moebius C, Melms J, Chiu WH, Goebel JN, Chakroun T, Koeglsperger T, Oertel WH, Rösler TW, Bickle M, Höglinger GU.

Sci Rep. 2017 Sep 13;7(1):11469. doi: 10.1038/s41598-017-11664-5.

6.

Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.

Jiang TF, Zhang YJ, Zhou HY, Wang HM, Tian LP, Liu J, Ding JQ, Chen SD.

J Neuroimmune Pharmacol. 2013 Mar;8(1):356-69. doi: 10.1007/s11481-012-9431-7. Epub 2013 Jan 17.

PMID:
23325107
7.

Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Dopamine Neurons and Can Alleviate α-Synuclein Disrupted Gene Expression.

Volakakis N, Tiklova K, Decressac M, Papathanou M, Mattsson B, Gillberg L, Nobre A, Björklund A, Perlmann T.

J Neurosci. 2015 Oct 21;35(42):14370-85. doi: 10.1523/JNEUROSCI.1155-15.2015.

8.

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy.

Xilouri M, Vogiatzi T, Vekrellis K, Park D, Stefanis L.

PLoS One. 2009;4(5):e5515. doi: 10.1371/journal.pone.0005515. Epub 2009 May 13.

9.

GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson's disease.

Decressac M, Ulusoy A, Mattsson B, Georgievska B, Romero-Ramos M, Kirik D, Björklund A.

Brain. 2011 Aug;134(Pt 8):2302-11. doi: 10.1093/brain/awr149. Epub 2011 Jun 28.

PMID:
21712347
10.

The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity.

Kim H, Calatayud C, Guha S, Fernández-Carasa I, Berkowitz L, Carballo-Carbajal I, Ezquerra M, Fernández-Santiago R, Kapahi P, Raya Á, Miranda-Vizuete A, Lizcano JM, Vila M, Caldwell KA, Caldwell GA, Consiglio A, Dalfo E.

Mol Neurobiol. 2018 Sep;55(9):7533-7552. doi: 10.1007/s12035-018-0881-7. Epub 2018 Feb 10. Erratum in: Mol Neurobiol. 2018 Apr 2;:.

11.

Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies.

Xilouri M, Brekk OR, Stefanis L.

Mov Disord. 2016 Feb;31(2):178-92. doi: 10.1002/mds.26477. Epub 2016 Jan 27. Review.

PMID:
26813776
12.

Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.

Mazzulli JR, Zunke F, Tsunemi T, Toker NJ, Jeon S, Burbulla LF, Patnaik S, Sidransky E, Marugan JJ, Sue CM, Krainc D.

J Neurosci. 2016 Jul 20;36(29):7693-706. doi: 10.1523/JNEUROSCI.0628-16.2016.

13.

The role of Galectin-3 in α-synuclein-induced microglial activation.

Boza-Serrano A, Reyes JF, Rey NL, Leffler H, Bousset L, Nilsson U, Brundin P, Venero JL, Burguillos MA, Deierborg T.

Acta Neuropathol Commun. 2014 Nov 12;2:156. doi: 10.1186/s40478-014-0156-0.

14.

Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons.

Rocha EM, Smith GA, Park E, Cao H, Brown E, Hayes MA, Beagan J, McLean JR, Izen SC, Perez-Torres E, Hallett PJ, Isacson O.

Neurobiol Dis. 2015 Oct;82:495-503. doi: 10.1016/j.nbd.2015.09.009. Epub 2015 Sep 25.

15.

17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy.

Riedel M, Goldbaum O, Schwarz L, Schmitt S, Richter-Landsberg C.

PLoS One. 2010 Jan 18;5(1):e8753. doi: 10.1371/journal.pone.0008753.

16.

Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration.

Xilouri M, Brekk OR, Landeck N, Pitychoutis PM, Papasilekas T, Papadopoulou-Daifoti Z, Kirik D, Stefanis L.

Brain. 2013 Jul;136(Pt 7):2130-46. doi: 10.1093/brain/awt131. Epub 2013 Jun 11.

PMID:
23757764
17.

Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease.

Lasser-Katz E, Simchovitz A, Chiu WH, Oertel WH, Sharon R, Soreq H, Roeper J, Goldberg JA.

J Neurosci. 2017 Jan 4;37(1):47-57. doi: 10.1523/JNEUROSCI.1079-16.2016.

18.

Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation.

Huang Y, Chegini F, Chua G, Murphy K, Gai W, Halliday GM.

Transl Neurodegener. 2012 Jan 13;1(1):2. doi: 10.1186/2047-9158-1-2.

19.

Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's disease.

Arawaka S, Fukushima S, Sato H, Sasaki A, Koga K, Koyama S, Kato T.

PLoS One. 2014 Feb 20;9(2):e89076. doi: 10.1371/journal.pone.0089076. eCollection 2014.

20.

NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease.

Zhang S, Glukhova SA, Caldwell KA, Caldwell GA.

Hum Mol Genet. 2017 Oct 1;26(19):3823-3836. doi: 10.1093/hmg/ddx269.

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