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Items: 1 to 20 of 94

1.

Biochemical and Proteomic Characterization of Recombinant Human α/β Hydrolase Domain 6.

Shields CM, Zvonok N, Zvonok A, Makriyannis A.

Sci Rep. 2019 Jan 29;9(1):890. doi: 10.1038/s41598-018-36633-4.

2.

Full mass spectrometric characterization of human monoacylglycerol lipase generated by large-scale expression and single-step purification.

Zvonok N, Williams J, Johnston M, Pandarinathan L, Janero DR, Li J, Krishnan SC, Makriyannis A.

J Proteome Res. 2008 May;7(5):2158-64. doi: 10.1021/pr700839z. Epub 2008 May 2.

3.

WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism.

Tanaka M, Moran S, Wen J, Affram K, Chen T, Symes AJ, Zhang Y.

J Neuroinflammation. 2017 Jan 10;14(1):7. doi: 10.1186/s12974-016-0783-4.

4.

Biochemical and mass spectrometric characterization of human N-acylethanolamine-hydrolyzing acid amidase inhibition.

West JM, Zvonok N, Whitten KM, Vadivel SK, Bowman AL, Makriyannis A.

PLoS One. 2012;7(8):e43877. doi: 10.1371/journal.pone.0043877. Epub 2012 Aug 31.

5.

Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).

Navia-Paldanius D, Savinainen JR, Laitinen JT.

J Lipid Res. 2012 Nov;53(11):2413-24. doi: 10.1194/jlr.M030411. Epub 2012 Sep 11.

6.

Activation of CB2 receptor is required for the therapeutic effect of ABHD6 inhibition in experimental autoimmune encephalomyelitis.

Wen J, Ribeiro R, Tanaka M, Zhang Y.

Neuropharmacology. 2015 Dec;99:196-209. doi: 10.1016/j.neuropharm.2015.07.010. Epub 2015 Jul 17.

PMID:
26189763
7.

Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors.

Patel JZ, van Bruchem J, Laitinen T, Kaczor AA, Navia-Paldanius D, Parkkari T, Savinainen JR, Laitinen JT, Nevalainen TJ.

Bioorg Med Chem. 2015 Oct 1;23(19):6335-45. doi: 10.1016/j.bmc.2015.08.030. Epub 2015 Aug 28.

PMID:
26344596
8.

The α/β-hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids.

Bottemanne P, Paquot A, Ameraoui H, Alhouayek M, Muccioli GG.

FASEB J. 2019 Jun;33(6):7635-7646. doi: 10.1096/fj.201802259R. Epub 2019 Mar 21.

PMID:
30896979
9.

Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.

Patel JZ, Nevalainen TJ, Savinainen JR, Adams Y, Laitinen T, Runyon RS, Vaara M, Ahenkorah S, Kaczor AA, Navia-Paldanius D, Gynther M, Aaltonen N, Joharapurkar AA, Jain MR, Haka AS, Maxfield FR, Laitinen JT, Parkkari T.

ChemMedChem. 2015 Feb;10(2):253-65. doi: 10.1002/cmdc.201402453. Epub 2014 Dec 11.

10.

Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6).

Hsu KL, Tsuboi K, Chang JW, Whitby LR, Speers AE, Pugh H, Cravatt BF.

J Med Chem. 2013 Nov 14;56(21):8270-9. doi: 10.1021/jm400899c. Epub 2013 Oct 23.

11.

Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor.

Zvonok N, Yaddanapudi S, Williams J, Dai S, Dong K, Rejtar T, Karger BL, Makriyannis A.

J Proteome Res. 2007 Jun;6(6):2068-79. Epub 2007 May 2.

PMID:
17472360
12.

Optimized Proteomic Mass Spectrometry Characterization of Recombinant Human μ-Opioid Receptor Functionally Expressed in Pichia pastoris Cell Lines.

Rosa M, Bech-Serra JJ, Canals F, Zajac JM, Talmont F, Arsequell G, Valencia G.

J Proteome Res. 2015 Aug 7;14(8):3162-73. doi: 10.1021/acs.jproteome.5b00104. Epub 2015 Jul 7.

PMID:
26090583
13.
15.

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors.

Marrs WR, Blankman JL, Horne EA, Thomazeau A, Lin YH, Coy J, Bodor AL, Muccioli GG, Hu SS, Woodruff G, Fung S, Lafourcade M, Alexander JP, Long JZ, Li W, Xu C, Möller T, Mackie K, Manzoni OJ, Cravatt BF, Stella N.

Nat Neurosci. 2010 Aug;13(8):951-7. doi: 10.1038/nn.2601. Epub 2010 Jul 25.

16.

Production of fully assembled and active Aquifex aeolicus F1FO ATP synthase in Escherichia coli.

Zhang C, Allegretti M, Vonck J, Langer JD, Marcia M, Peng G, Michel H.

Biochim Biophys Acta. 2014 Jan;1840(1):34-40. doi: 10.1016/j.bbagen.2013.08.023. Epub 2013 Sep 1.

PMID:
24005236
17.

Comparative molecular field analysis and molecular dynamics studies of α/β hydrolase domain containing 6 (ABHD6) inhibitors.

Kaczor AA, Targowska-Duda KM, Patel JZ, Laitinen T, Parkkari T, Adams Y, Nevalainen TJ, Poso A.

J Mol Model. 2015 Oct;21(10):250. doi: 10.1007/s00894-015-2789-8. Epub 2015 Sep 8.

19.

A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile--the pharmacological importance of post-translational modifications.

Bergeron ZL, Chun JB, Baker MR, Sandall DW, Peigneur S, Yu PY, Thapa P, Milisen JW, Tytgat J, Livett BG, Bingham JP.

Peptides. 2013 Nov;49:145-58. doi: 10.1016/j.peptides.2013.09.004. Epub 2013 Sep 18.

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