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Items: 1 to 20 of 98

1.

Advanced Methods for Accessing Protein Shape-Shifting Present New Therapeutic Opportunities.

Knoverek CR, Amarasinghe GK, Bowman GR.

Trends Biochem Sci. 2018 Dec 13. pii: S0968-0004(18)30248-2. doi: 10.1016/j.tibs.2018.11.007. [Epub ahead of print] Review.

PMID:
30555007
2.

Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets.

Ashford P, Moss DS, Alex A, Yeap SK, Povia A, Nobeli I, Williams MA.

BMC Bioinformatics. 2012 Mar 14;13:39. doi: 10.1186/1471-2105-13-39.

3.

Macromolecular crowding: chemistry and physics meet biology (Ascona, Switzerland, 10-14 June 2012).

Foffi G, Pastore A, Piazza F, Temussi PA.

Phys Biol. 2013 Aug;10(4):040301. Epub 2013 Aug 2.

PMID:
23912807
4.
5.

Designing small molecules to target cryptic pockets yields both positive and negative allosteric modulators.

Hart KM, Moeder KE, Ho CMW, Zimmerman MI, Frederick TE, Bowman GR.

PLoS One. 2017 Jun 1;12(6):e0178678. doi: 10.1371/journal.pone.0178678. eCollection 2017.

6.

Harnessing allostery: a novel approach to drug discovery.

Lu S, Li S, Zhang J.

Med Res Rev. 2014 Nov;34(6):1242-85. doi: 10.1002/med.21317. Epub 2014 May 14. Review.

PMID:
24827416
7.

Contrasting roles of dynamics in protein allostery: NMR and structural studies of CheY and the third PDZ domain from PSD-95.

Lee AL.

Biophys Rev. 2015 Jun;7(2):217-226. doi: 10.1007/s12551-015-0169-3. Epub 2015 Apr 22. Review.

8.

Exploiting protein flexibility to predict the location of allosteric sites.

Panjkovich A, Daura X.

BMC Bioinformatics. 2012 Oct 25;13:273. doi: 10.1186/1471-2105-13-273.

9.

Equilibrium fluctuations of a single folded protein reveal a multitude of potential cryptic allosteric sites.

Bowman GR, Geissler PL.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11681-6. doi: 10.1073/pnas.1209309109. Epub 2012 Jul 2.

10.

Study of Functional and Allosteric Sites in Protein Superfamilies.

Suplatov D, Švedas V.

Acta Naturae. 2015 Oct-Dec;7(4):34-45.

11.

Dynamic profile analysis to characterize dynamics-driven allosteric sites in enzymes.

Taguchi J, Kitao A.

Biophys Physicobiol. 2016 Jul 14;13:117-126. eCollection 2016.

12.

Structure-based prediction of protein allostery.

Greener JG, Sternberg MJ.

Curr Opin Struct Biol. 2018 Jun;50:1-8. doi: 10.1016/j.sbi.2017.10.002. Epub 2017 Nov 5. Review.

13.

Emerging computational approaches for the study of protein allostery.

Collier G, Ortiz V.

Arch Biochem Biophys. 2013 Oct 1;538(1):6-15. doi: 10.1016/j.abb.2013.07.025. Epub 2013 Aug 8. Review.

PMID:
23933229
14.

A Chemical Perspective on Allostery.

Ribeiro AA, Ortiz V.

Chem Rev. 2016 Jun 8;116(11):6488-502. doi: 10.1021/acs.chemrev.5b00543. Epub 2016 Jan 7. Review.

PMID:
26741913
15.

Allosteric Communication Networks in Proteins Revealed through Pocket Crosstalk Analysis.

La Sala G, Decherchi S, De Vivo M, Rocchia W.

ACS Cent Sci. 2017 Sep 27;3(9):949-960. doi: 10.1021/acscentsci.7b00211. Epub 2017 Aug 10.

16.

Protein Binding Pocket Dynamics.

Stank A, Kokh DB, Fuller JC, Wade RC.

Acc Chem Res. 2016 May 17;49(5):809-15. doi: 10.1021/acs.accounts.5b00516. Epub 2016 Apr 25. Review.

17.

Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands.

Vettoretti G, Moroni E, Sattin S, Tao J, Agard DA, Bernardi A, Colombo G.

Sci Rep. 2016 Apr 1;6:23830. doi: 10.1038/srep23830.

18.

A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance.

Furlong EJ, Lo AW, Kurth F, Premkumar L, Totsika M, Achard MES, Halili MA, Heras B, Whitten AE, Choudhury HG, Schembri MA, Martin JL.

Nat Commun. 2017 Jul 19;8:16065. doi: 10.1038/ncomms16065.

19.

The Role of Protein Loops and Linkers in Conformational Dynamics and Allostery.

Papaleo E, Saladino G, Lambrughi M, Lindorff-Larsen K, Gervasio FL, Nussinov R.

Chem Rev. 2016 Jun 8;116(11):6391-423. doi: 10.1021/acs.chemrev.5b00623. Epub 2016 Feb 18. Review.

PMID:
26889708
20.

Discovery of multiple hidden allosteric sites by combining Markov state models and experiments.

Bowman GR, Bolin ER, Hart KM, Maguire BC, Marqusee S.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2734-9. doi: 10.1073/pnas.1417811112. Epub 2015 Feb 17.

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