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Items: 1 to 20 of 113

1.

Transcriptomic Data Mining and Repurposing for Computational Drug Discovery.

Wang Y, Yella J, Jegga AG.

Methods Mol Biol. 2019;1903:73-95. doi: 10.1007/978-1-4939-8955-3_5.

PMID:
30547437
2.

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics.

O'Reilly PG, Wen Q, Bankhead P, Dunne PD, McArt DG, McPherson S, Hamilton PW, Mills KI, Zhang SD.

BMC Bioinformatics. 2016 May 4;17(1):198. doi: 10.1186/s12859-016-1062-1.

3.

Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapies.

Wen Q, O'Reilly P, Dunne PD, Lawler M, Van Schaeybroeck S, Salto-Tellez M, Hamilton P, Zhang SD.

BMC Syst Biol. 2015;9 Suppl 5:S4. doi: 10.1186/1752-0509-9-S5-S4. Epub 2015 Sep 1.

4.

Computational drug repositioning through heterogeneous network clustering.

Wu C, Gudivada RC, Aronow BJ, Jegga AG.

BMC Syst Biol. 2013;7 Suppl 5:S6. doi: 10.1186/1752-0509-7-S5-S6. Epub 2013 Dec 9.

5.

Computational Drug Repurposing: Current Trends.

Karaman B, Sippl W.

Curr Med Chem. 2018 May 29. doi: 10.2174/0929867325666180530100332. [Epub ahead of print]

PMID:
29848268
6.

A novel computational approach for drug repurposing using systems biology.

Peyvandipour A, Saberian N, Shafi A, Donato M, Draghici S.

Bioinformatics. 2018 Aug 15;34(16):2817-2825. doi: 10.1093/bioinformatics/bty133.

PMID:
29534151
7.

New drug candidates for treatment of atypical meningiomas: An integrated approach using gene expression signatures for drug repurposing.

Zador Z, King AT, Geifman N.

PLoS One. 2018 Mar 20;13(3):e0194701. doi: 10.1371/journal.pone.0194701. eCollection 2018.

8.

Connecting genetics and gene expression data for target prioritisation and drug repositioning.

Ferrero E, Agarwal P.

BioData Min. 2018 May 31;11:7. doi: 10.1186/s13040-018-0171-y. eCollection 2018.

9.

Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds.

Carrella D, Manni I, Tumaini B, Dattilo R, Papaccio F, Mutarelli M, Sirci F, Amoreo CA, Mottolese M, Iezzi M, Ciolli L, Aria V, Bosotti R, Isacchi A, Loreni F, Bardelli A, Avvedimento VE, di Bernardo D, Cardone L.

Oncotarget. 2016 Sep 13;7(37):58743-58758. doi: 10.18632/oncotarget.11318.

10.

Drug repurposing: a better approach for infectious disease drug discovery?

Law GL, Tisoncik-Go J, Korth MJ, Katze MG.

Curr Opin Immunol. 2013 Oct;25(5):588-92. doi: 10.1016/j.coi.2013.08.004. Epub 2013 Sep 5. Review.

11.

An update on Drug Repurposing: Re-written saga of the drug's fate.

Gns HS, Gr S, Murahari M, Krishnamurthy M.

Biomed Pharmacother. 2019 Feb;110:700-716. doi: 10.1016/j.biopha.2018.11.127. Epub 2018 Dec 12. Review.

12.

Master Regulators Connectivity Map: A Transcription Factors-Centered Approach to Drug Repositioning.

De Bastiani MA, Pfaffenseller B, Klamt F.

Front Pharmacol. 2018 Jul 2;9:697. doi: 10.3389/fphar.2018.00697. eCollection 2018.

13.

REPRODUCIBLE DRUG REPURPOSING: WHEN SIMILARITY DOES NOT SUFFICE.

Guney E.

Pac Symp Biocomput. 2017;22:132-143. doi: 10.1142/9789813207813_0014.

14.

Computational drug repurposing to predict approved and novel drug-disease associations.

Khalid Z, Sezerman OU.

J Mol Graph Model. 2018 Oct;85:91-96. doi: 10.1016/j.jmgm.2018.08.005. Epub 2018 Aug 14.

PMID:
30130693
15.

Drug repositioning for personalized medicine.

Li YY, Jones SJ.

Genome Med. 2012 Mar 30;4(3):27. doi: 10.1186/gm326. eCollection 2012. Review.

16.

Exploring Polypharmacology in Drug Discovery and Repurposing Using the CANDO Platform.

Chopra G, Samudrala R.

Curr Pharm Des. 2016;22(21):3109-23. Review.

PMID:
27013226
17.

An Application of Computational Drug Repurposing Based on Transcriptomic Signatures.

Karatzas E, Kolios G, Spyrou GM.

Methods Mol Biol. 2019;1903:149-177. doi: 10.1007/978-1-4939-8955-3_9.

PMID:
30547441
18.

Drug repurposing by integrated literature mining and drug-gene-disease triangulation.

Sun P, Guo J, Winnenburg R, Baumbach J.

Drug Discov Today. 2017 Apr;22(4):615-619. doi: 10.1016/j.drudis.2016.10.008. Epub 2016 Oct 22.

PMID:
27780789
19.

From gene networks to drugs: systems pharmacology approaches for AUD.

Ferguson LB, Harris RA, Mayfield RD.

Psychopharmacology (Berl). 2018 Jun;235(6):1635-1662. doi: 10.1007/s00213-018-4855-2. Epub 2018 Mar 1. Review.

20.

Identifying Protein Features Responsible for Improved Drug Repurposing Accuracies Using the CANDO Platform: Implications for Drug Design.

Mangione W, Samudrala R.

Molecules. 2019 Jan 4;24(1). pii: E167. doi: 10.3390/molecules24010167.

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