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Items: 1 to 20 of 118

1.

Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents.

Majcher U, Klejborowska G, Kaik M, Maj E, Wietrzyk J, Moshari M, Preto J, Tuszynski JA, Huczyński A.

Cells. 2018 Nov 19;7(11). pii: E216. doi: 10.3390/cells7110216.

2.

Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives.

Majcher U, Klejborowska G, Moshari M, Maj E, Wietrzyk J, Bartl F, Tuszynski JA, Huczyński A.

Cells. 2018 Nov 1;7(11). pii: E192. doi: 10.3390/cells7110192.

3.

Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes.

Majcher U, Urbaniak A, Maj E, Moshari M, Delgado M, Wietrzyk J, Bartl F, Chambers TC, Tuszynski JA, Huczyński A.

Bioorg Chem. 2018 Dec;81:553-566. doi: 10.1016/j.bioorg.2018.09.004. Epub 2018 Sep 12.

PMID:
30248507
4.

Synthesis, antiproliferative activity and molecular docking of Colchicine derivatives.

Huczyński A, Majcher U, Maj E, Wietrzyk J, Janczak J, Moshari M, Tuszynski JA, Bartl F.

Bioorg Chem. 2016 Feb;64:103-12. doi: 10.1016/j.bioorg.2016.01.002. Epub 2016 Jan 12.

PMID:
26794327
5.

Synthesis, antiproliferative and antibacterial evaluation of C-ring modified colchicine analogues.

Huczyński A, Rutkowski J, Popiel K, Maj E, Wietrzyk J, Stefańska J, Majcher U, Bartl F.

Eur J Med Chem. 2015 Jan 27;90:296-301. doi: 10.1016/j.ejmech.2014.11.037. Epub 2014 Nov 22.

PMID:
25437616
6.

Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.

Liu YN, Wang JJ, Ji YT, Zhao GD, Tang LQ, Zhang CM, Guo XL, Liu ZP.

J Med Chem. 2016 Jun 9;59(11):5341-55. doi: 10.1021/acs.jmedchem.6b00071. Epub 2016 May 20.

PMID:
27172319
8.

Stereochemical preference toward oncotarget: Design, synthesis and in vitro anticancer evaluation of diastereomeric β-lactams.

Olazarán-Santibáñez F, Bandyopadhyay D, Carranza-Rosales P, Rivera G, Balderas-Rentería I.

Oncotarget. 2017 Jun 6;8(23):37773-37782. doi: 10.18632/oncotarget.18077.

9.

Synthesis and biological evaluation of novel benzo[c]acridine-diones as potential anticancer agents and tubulin polymerization inhibitors.

Behbahani FS, Tabeshpour J, Mirzaei S, Golmakaniyoon S, Tayarani-Najaran Z, Ghasemi A, Ghodsi R.

Arch Pharm (Weinheim). 2019 Apr 23:e1800307. doi: 10.1002/ardp.201800307. [Epub ahead of print]

PMID:
31012156
10.

Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents.

Madadi NR, Penthala NR, Ketkar A, Eoff RL, Trujullo-Alonso V, Guzman ML, Crooks PA.

Anticancer Agents Med Chem. 2018;18(4):556-564. doi: 10.2174/1871521409666170412115703.

PMID:
28403783
11.

Design, synthesis and molecular modeling of new 4-phenylcoumarin derivatives as tubulin polymerization inhibitors targeting MCF-7 breast cancer cells.

Batran RZ, Kassem AF, Abbas EMH, Elseginy SA, Mounier MM.

Bioorg Med Chem. 2018 Jul 23;26(12):3474-3490. doi: 10.1016/j.bmc.2018.05.022. Epub 2018 May 16.

PMID:
29793751
12.

Chemical synthesis, pharmacological evaluation and in silico analysis of new 2,3,3a,4,5,6-hexahydrocyclopenta[c]pyrazole derivatives as potential anti-mitotic agents.

Minu M, Singh D, Mahaddalkar T, Lopus M, Winter P, Ayoub AT, Missiaen K, Tilli TM, Pasdar M, Tuszynski J.

Bioorg Med Chem Lett. 2016 Aug 15;26(16):3855-61. doi: 10.1016/j.bmcl.2016.07.025. Epub 2016 Jul 9.

PMID:
27449957
13.

Synthesis, molecular docking and biological evaluation of 1-phenylsulphonyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as novel potential tubulin assembling inhibitors.

Wang YT, Cai XC, Shi TQ, Zhang YL, Wang ZC, Liu CH, Zhu HL.

Chem Biol Drug Des. 2017 Jul;90(1):112-118. doi: 10.1111/cbdd.12932. Epub 2017 Feb 15.

PMID:
28032450
14.

Interactions of long-chain homologues of colchicine with tubulin.

Marzo-Mas A, Barbier P, Breuzard G, Allegro D, Falomir E, Murga J, Carda M, Peyrot V, Marco JA.

Eur J Med Chem. 2017 Jan 27;126:526-535. doi: 10.1016/j.ejmech.2016.11.049. Epub 2016 Nov 23.

PMID:
27915168
15.
16.

Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents.

Carta D, Bortolozzi R, Sturlese M, Salmaso V, Hamel E, Basso G, Calderan L, Quintieri L, Moro S, Viola G, Ferlin MG.

Eur J Med Chem. 2017 Feb 15;127:643-660. doi: 10.1016/j.ejmech.2016.10.026. Epub 2016 Oct 21.

17.

Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site.

Lai Q, Wang Y, Wang R, Lai W, Tang L, Tao Y, Liu Y, Zhang R, Huang L, Xiang H, Zeng S, Gou L, Chen H, Yao Y, Yang J.

Eur J Med Chem. 2018 Aug 5;156:162-179. doi: 10.1016/j.ejmech.2018.05.010. Epub 2018 May 10.

PMID:
30006162
18.

Docking, synthesis and antiproliferative activity of N-acylhydrazone derivatives designed as combretastatin A4 analogues.

do Amaral DN, Cavalcanti BC, Bezerra DP, Ferreira PM, Castro Rde P, Sabino JR, Machado CM, Chammas R, Pessoa C, Sant'Anna CM, Barreiro EJ, Lima LM.

PLoS One. 2014 Mar 10;9(3):e85380. doi: 10.1371/journal.pone.0085380. eCollection 2014.

19.

Molecular Docking, G-QSAR studies, Synthesis and Anticancer screening of some New 2-Phenazinamines as Bcr-Abl Tyrosine kinase Inhibitors.

Kale MA, Sonwane GM.

Curr Drug Discov Technol. 2018 Sep 13. doi: 10.2174/1570163815666180913122542. [Epub ahead of print]

PMID:
30210004
20.

Effects on tubulin polymerization and down-regulation of c-Myc, hTERT and VEGF genes by colchicine haloacetyl and haloaroyl derivatives.

Marzo-Mas A, Falomir E, Murga J, Carda M, Marco JA.

Eur J Med Chem. 2018 Apr 25;150:591-600. doi: 10.1016/j.ejmech.2018.03.019. Epub 2018 Mar 8.

PMID:
29550732

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