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Items: 1 to 20 of 125

1.

Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes.

Majcher U, Urbaniak A, Maj E, Moshari M, Delgado M, Wietrzyk J, Bartl F, Chambers TC, Tuszynski JA, Huczyński A.

Bioorg Chem. 2018 Dec;81:553-566. doi: 10.1016/j.bioorg.2018.09.004. Epub 2018 Sep 12.

PMID:
30248507
2.

2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition.

Romagnoli R, Kimatrai Salvador M, Schiaffino Ortega S, Baraldi PG, Oliva P, Baraldi S, Lopez-Cara LC, Brancale A, Ferla S, Hamel E, Balzarini J, Liekens S, Mattiuzzo E, Basso G, Viola G.

Eur J Med Chem. 2018 Jan 1;143:683-698. doi: 10.1016/j.ejmech.2017.11.096.

3.

Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site.

Lai Q, Wang Y, Wang R, Lai W, Tang L, Tao Y, Liu Y, Zhang R, Huang L, Xiang H, Zeng S, Gou L, Chen H, Yao Y, Yang J.

Eur J Med Chem. 2018 Aug 5;156:162-179. doi: 10.1016/j.ejmech.2018.05.010. Epub 2018 May 10.

PMID:
30006162
4.

Design and synthesis of novel 5-(4-chlorophenyl)furan derivatives with inhibitory activity on tubulin polymerization.

Moussa SA, A Osman EE, Eid NM, Abou-Seri SM, El Moghazy SM.

Future Med Chem. 2018 Aug 1;10(16):1907-1924. doi: 10.4155/fmc-2018-0036. Epub 2018 Jul 3.

PMID:
29966433
5.

Hybrid Pharmacophore Design, Molecular Docking, Synthesis, and Biological Evaluation of Novel Aldimine-Type Schiff Base Derivatives as Tubulin Polymerization Inhibitor.

Ameri A, Khodarahmi G, Forootanfar H, Hassanzadeh F, Hakimelahi GH.

Chem Biodivers. 2018 Mar;15(3):e1700518. doi: 10.1002/cbdv.201700518. Epub 2018 Mar 7.

PMID:
29292595
6.

Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.

Liu YN, Wang JJ, Ji YT, Zhao GD, Tang LQ, Zhang CM, Guo XL, Liu ZP.

J Med Chem. 2016 Jun 9;59(11):5341-55. doi: 10.1021/acs.jmedchem.6b00071. Epub 2016 May 20.

PMID:
27172319
7.
8.

Novel Aldimine-Type Schiff Bases of 4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-1,2,4-triazole-3-thione/thiol: Docking Study, Synthesis, Biological Evaluation, and Anti-Tubulin Activity.

Ameri A, Khodarahmi G, Hassanzadeh F, Forootanfar H, Hakimelahi GH.

Arch Pharm (Weinheim). 2016 Aug;349(8):662-81. doi: 10.1002/ardp.201600021. Epub 2016 Jun 19.

PMID:
27320785
9.

Synthesis, antiproliferative activity and molecular docking of Colchicine derivatives.

Huczyński A, Majcher U, Maj E, Wietrzyk J, Janczak J, Moshari M, Tuszynski JA, Bartl F.

Bioorg Chem. 2016 Feb;64:103-12. doi: 10.1016/j.bioorg.2016.01.002. Epub 2016 Jan 12.

PMID:
26794327
10.

Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents.

Liu Y, Wei D, Zhao Y, Cheng W, Lu Y, Ma Y, Li X, Han C, Wei Y, Cao H, Zhao C.

Bioorg Med Chem. 2012 Nov 1;20(21):6285-95. doi: 10.1016/j.bmc.2012.09.009. Epub 2012 Sep 13.

PMID:
23022053
11.

Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin.

Sharma A, Sáez-Calvo G, Olieric N, de Asís Balaguer F, Barasoain I, Lamberth C, Díaz JF, Steinmetz MO.

Int J Mol Sci. 2017 Jun 22;18(7). pii: E1336. doi: 10.3390/ijms18071336.

12.

Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents.

Penthala NR, Zong H, Ketkar A, Madadi NR, Janganati V, Eoff RL, Guzman ML, Crooks PA.

Eur J Med Chem. 2015 Mar 6;92:212-20. doi: 10.1016/j.ejmech.2014.12.050. Epub 2014 Dec 29.

13.

Design, synthesis, and biological evaluation of novel combretastatin A-4 thio derivatives as microtubule targeting agents.

Stefański T, Mikstacka R, Kurczab R, Dutkiewicz Z, Kucińska M, Murias M, Zielińska-Przyjemska M, Cichocki M, Teubert A, Kaczmarek M, Hogendorf A, Sobiak S.

Eur J Med Chem. 2018 Jan 20;144:797-816. doi: 10.1016/j.ejmech.2017.11.050. Epub 2017 Dec 12.

PMID:
29291446
14.

Synthesis and biological evaluation of podophyllotoxin congeners as tubulin polymerization inhibitors.

Kamal A, Srinivasa Reddy T, Polepalli S, Shalini N, Reddy VG, Subba Rao AV, Jain N, Shankaraiah N.

Bioorg Med Chem. 2014 Oct 1;22(19):5466-75. doi: 10.1016/j.bmc.2014.07.031. Epub 2014 Jul 27.

PMID:
25131956
15.

Synthesis and Biological Evaluations of 1,2-Diaryl Pyrroles as Analogues of Combretastatin A-4.

Sun J, Chen L, Liu C, Wang Z, Zuo D, Pan J, Qi H, Bao K, Wu Y, Zhang W.

Chem Biol Drug Des. 2015 Dec;86(6):1541-7. doi: 10.1111/cbdd.12617. Epub 2015 Sep 25.

PMID:
26202587
16.

Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues.

Mustafa M, Abdelhamid D, Abdelhafez EMN, Ibrahim MAA, Gamal-Eldeen AM, Aly OM.

Eur J Med Chem. 2017 Dec 1;141:293-305. doi: 10.1016/j.ejmech.2017.09.063. Epub 2017 Sep 28.

PMID:
29031074
17.

Design, synthesis and biological evaluation of novel pyrazoline-containing derivatives as potential tubulin assembling inhibitors.

Qin YJ, Li YJ, Jiang AQ, Yang MR, Zhu QZ, Dong H, Zhu HL.

Eur J Med Chem. 2015 Apr 13;94:447-57. doi: 10.1016/j.ejmech.2015.02.058. Epub 2015 Mar 3.

PMID:
25828827
18.

Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents.

Carta D, Bortolozzi R, Sturlese M, Salmaso V, Hamel E, Basso G, Calderan L, Quintieri L, Moro S, Viola G, Ferlin MG.

Eur J Med Chem. 2017 Feb 15;127:643-660. doi: 10.1016/j.ejmech.2016.10.026. Epub 2016 Oct 21.

19.

Design, Synthesis and Molecular Docking Studies of Novel Indole-Pyrimidine Hybrids as Tubulin Polymerization Inhibitors.

Hu MJ, Zhang B, Yang HK, Liu Y, Chen YR, Ma TZ, Lu L, You WW, Zhao PL.

Chem Biol Drug Des. 2015 Dec;86(6):1491-500. doi: 10.1111/cbdd.12616. Epub 2015 Aug 3.

PMID:
26177395
20.

Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.

Zhang X, Kong Y, Zhang J, Su M, Zhou Y, Zang Y, Li J, Chen Y, Fang Y, Zhang X, Lu W.

Eur J Med Chem. 2015 May 5;95:127-35. doi: 10.1016/j.ejmech.2015.03.035. Epub 2015 Mar 18.

PMID:
25805446

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