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Items: 1 to 20 of 98

1.

Commentary on Giralt et al.: PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease.

Polis B, Gil-Henn H.

Exp Neurol. 2019 Jan;311:313-317. doi: 10.1016/j.expneurol.2018.08.011. Epub 2018 Aug 29.

PMID:
30171866
2.

PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease.

Giralt A, de Pins B, Cifuentes-Díaz C, López-Molina L, Farah AT, Tible M, Deramecourt V, Arold ST, Ginés S, Hugon J, Girault JA.

Exp Neurol. 2018 Sep;307:62-73. doi: 10.1016/j.expneurol.2018.05.020. Epub 2018 May 24.

PMID:
29803828
3.

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.

Giralt A, Brito V, Chevy Q, Simonnet C, Otsu Y, Cifuentes-Díaz C, de Pins B, Coura R, Alberch J, Ginés S, Poncer JC, Girault JA.

Nat Commun. 2017 May 30;8:15592. doi: 10.1038/ncomms15592.

4.

Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn.

Li C, Götz J.

J Alzheimers Dis. 2018;64(1):205-221. doi: 10.3233/JAD-180054.

5.

Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss.

Lee S, Salazar SV, Cox TO, Strittmatter SM.

J Neurosci. 2019 Mar 6;39(10):1910-1929. doi: 10.1523/JNEUROSCI.2983-18.2018. Epub 2019 Jan 9.

PMID:
30626696
6.

Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein.

Xiong WC, Macklem M, Parsons JT.

J Cell Sci. 1998 Jul 30;111 ( Pt 14):1981-91.

7.

Chronic Estradiol Administration During the Early Stage of Alzheimer's Disease Pathology Rescues Adult Hippocampal Neurogenesis and Ameliorates Cognitive Deficits in Aβ1-42 Mice.

Zheng JY, Liang KS, Wang XJ, Zhou XY, Sun J, Zhou SN.

Mol Neurobiol. 2017 Dec;54(10):7656-7669. doi: 10.1007/s12035-016-0181-z. Epub 2016 Nov 12.

PMID:
27838872
8.

Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss.

Ager RR, Davis JL, Agazaryan A, Benavente F, Poon WW, LaFerla FM, Blurton-Jones M.

Hippocampus. 2015 Jul;25(7):813-26. doi: 10.1002/hipo.22405. Epub 2015 Jan 8.

9.

Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss.

Salazar SV, Cox TO, Lee S, Brody AH, Chyung AS, Haas LT, Strittmatter SM.

J Neurosci. 2019 Jan 23;39(4):758-772. doi: 10.1523/JNEUROSCI.1873-18.2018. Epub 2018 Dec 5.

PMID:
30518596
10.

Dihydromyricetin ameliorates behavioral deficits and reverses neuropathology of transgenic mouse models of Alzheimer's disease.

Liang J, López-Valdés HE, Martínez-Coria H, Lindemeyer AK, Shen Y, Shao XM, Olsen RW.

Neurochem Res. 2014 Jun;39(6):1171-81. doi: 10.1007/s11064-014-1304-4. Epub 2014 Apr 13. Erratum in: Neurochem Res. 2014 Jul;39(7):1403.

PMID:
24728903
11.
12.

The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.

Cipolla L, Consonni A, Guidetti G, Canobbio I, Okigaki M, Falasca M, Ciraolo E, Hirsch E, Balduini C, Torti M.

J Thromb Haemost. 2013 Feb;11(2):345-56. doi: 10.1111/jth.12099.

13.

Depolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slices.

Corvol JC, Valjent E, Toutant M, Enslen H, Irinopoulou T, Lev S, Hervé D, Girault JA.

J Biol Chem. 2005 Jan 7;280(1):660-8. Epub 2004 Nov 10.

14.

Common variant in PTK2B is associated with late-onset Alzheimer's disease: A replication study and meta-analyses.

Li YQ, Tan MS, Wang HF, Tan CC, Zhang W, Zheng ZJ, Kong LL, Wang ZX, Tan L, Jiang T, Tan L, Yu JT.

Neurosci Lett. 2016 May 16;621:83-87. doi: 10.1016/j.neulet.2016.04.020. Epub 2016 Apr 11.

PMID:
27080426
15.

Sperm-oocyte contact induces outside-in signaling via PYK2 activation.

Wang H, Luo J, Carlton C, McGinnis LK, Kinsey WH.

Dev Biol. 2017 Aug 1;428(1):52-62. doi: 10.1016/j.ydbio.2017.05.016. Epub 2017 May 17.

16.

Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation.

Sun CK, Man K, Ng KT, Ho JW, Lim ZX, Cheng Q, Lo CM, Poon RT, Fan ST.

Carcinogenesis. 2008 Nov;29(11):2096-105. doi: 10.1093/carcin/bgn203. Epub 2008 Sep 1.

PMID:
18765415
17.
18.

Proline-rich tyrosine kinase 2 regulates hippocampal long-term depression.

Hsin H, Kim MJ, Wang CF, Sheng M.

J Neurosci. 2010 Sep 8;30(36):11983-93. doi: 10.1523/JNEUROSCI.1029-10.2010.

19.

The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer's disease.

Gu XH, Xu LJ, Liu ZQ, Wei B, Yang YJ, Xu GG, Yin XP, Wang W.

Behav Brain Res. 2016 Sep 15;311:309-321. doi: 10.1016/j.bbr.2016.05.052. Epub 2016 May 24.

PMID:
27233830
20.

Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice.

Liu Y, Xu YF, Zhang L, Huang L, Yu P, Zhu H, Deng W, Qin C.

CNS Neurosci Ther. 2017 Jul;23(7):590-604. doi: 10.1111/cns.12706. Epub 2017 Jun 8.

PMID:
28597477

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