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UBC-Nepal expedition: upper and lower limb conduit artery shear stress and flow-mediated dilation on ascent to 5,050 m in lowlanders and Sherpa.

Tremblay JC, Hoiland RL, Carter HH, Howe CA, Stembridge M, Willie CK, Gasho C, MacLeod DB, Pyke KE, Ainslie PN.

Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1532-H1543. doi: 10.1152/ajpheart.00345.2018. Epub 2018 Aug 31.


UBC-Nepal Expedition: imposed oscillatory shear stress does not further attenuate flow-mediated dilation during acute and sustained hypoxia.

Tremblay JC, Howe CA, Ainslie PN, Pyke KE.

Am J Physiol Heart Circ Physiol. 2018 Jul 1;315(1):H122-H131. doi: 10.1152/ajpheart.00717.2017. Epub 2018 Mar 9.


UBC-Nepal expedition: phenotypical evidence for evolutionary adaptation in the control of cerebral blood flow and oxygen delivery at high altitude.

Hoiland RL, Howe CA, Carter HH, Tremblay JC, Willie CK, Donnelly J, MacLeod DB, Gasho C, Stembridge M, Boulet LM, Niroula S, Ainslie PN.

J Physiol. 2019 Jun;597(12):2993-3008. doi: 10.1113/JP277596. Epub 2019 May 13.


Conduit artery structure and function in lowlanders and native highlanders: relationships with oxidative stress and role of sympathoexcitation.

Lewis NC, Bailey DM, Dumanoir GR, Messinger L, Lucas SJ, Cotter JD, Donnelly J, McEneny J, Young IS, Stembridge M, Burgess KR, Basnet AS, Ainslie PN.

J Physiol. 2014 Mar 1;592(5):1009-24. doi: 10.1113/jphysiol.2013.268615. Epub 2013 Dec 9.


Impact of shear rate pattern on upper and lower limb conduit artery endothelial function in both spinal cord-injured and able-bodied men.

Totosy de Zepetnek JO, Ditor DS, Au JS, MacDonald MJ.

Exp Physiol. 2015 Oct;100(10):1107-17. doi: 10.1113/EP085056. Epub 2015 Aug 18.


UBC-Nepal Expedition: An experimental overview of the 2016 University of British Columbia Scientific Expedition to Nepal Himalaya.

Willie CK, Stembridge M, Hoiland RL, Tymko MM, Tremblay JC, Patrician A, Steinback C, Moore J, Anholm J, Subedi P, Niroula S, McNeil CJ, McManus A, MacLeod DB, Ainslie PN.

PLoS One. 2018 Oct 31;13(10):e0204660. doi: 10.1371/journal.pone.0204660. eCollection 2018.


UBC-Nepal expedition: peripheral fatigue recovers faster in Sherpa than lowlanders at high altitude.

Ruggiero L, Hoiland RL, Hansen AB, Ainslie PN, McNeil CJ.

J Physiol. 2018 Nov;596(22):5365-5377. doi: 10.1113/JP276599. Epub 2018 Oct 13.


Sublingual microcirculatory blood flow and vessel density in Sherpas at high altitude.

Gilbert-Kawai E, Coppel J, Court J, van der Kaaij J, Vercueil A, Feelisch M, Levett D, Mythen M, Grocott MP, Martin D; Xtreme Everest 2 Research Group.

J Appl Physiol (1985). 2017 Apr 1;122(4):1011-1018. doi: 10.1152/japplphysiol.00970.2016. Epub 2017 Jan 26.


Flow-mediated dilation stimulated by sustained increases in shear stress: a useful tool for assessing endothelial function in humans?

Tremblay JC, Pyke KE.

Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H508-H520. doi: 10.1152/ajpheart.00534.2017. Epub 2017 Nov 22. Review.


Sustained vasomotor control of skin microcirculation in Sherpas versus altitude-naive lowlanders: Experimental evidence from Xtreme Everest 2.

Davies T, Gilbert-Kawai E, Wythe S, Meale P, Mythen M, Levett D, Mitchell K, Grocott M, Clough G, Martin D; Xtreme Everest 2 Research Group.

Exp Physiol. 2018 Nov;103(11):1494-1504. doi: 10.1113/EP087236. Epub 2018 Sep 12.


UBC-Nepal Expedition: acute alterations in sympathetic nervous activity do not influence brachial artery endothelial function at sea level and high altitude.

Tymko MM, Tremblay JC, Steinback CD, Moore JP, Hansen AB, Patrician A, Howe CA, Hoiland RL, Green DJ, Ainslie PN.

J Appl Physiol (1985). 2017 Nov 1;123(5):1386-1396. doi: 10.1152/japplphysiol.00583.2017. Epub 2017 Aug 31.


Evidence of a limb and shear stress stimulus profile dependent impact of high intensity cycling training on flow-mediated dilation.

King TJ, Pyke KE.

Appl Physiol Nutr Metab. 2019 Jun 28. doi: 10.1139/apnm-2019-0151. [Epub ahead of print]


Baroreflex control of sympathetic vasomotor activity and resting arterial pressure at high altitude: insight from Lowlanders and Sherpa.

Simpson LL, Busch SA, Oliver SJ, Ainslie PN, Stembridge M, Steinback CD, Moore JP.

J Physiol. 2019 May;597(9):2379-2390. doi: 10.1113/JP277663. Epub 2019 Apr 7.


Evidence of sex differences in the acute impact of oscillatory shear stress on endothelial function.

Tremblay JC, Stimpson TV, Pyke KE.

J Appl Physiol (1985). 2019 Feb 1;126(2):314-321. doi: 10.1152/japplphysiol.00729.2018. Epub 2018 Nov 1.


UBC-Nepal expedition: markedly lower cerebral blood flow in high-altitude Sherpa children compared with children residing at sea level.

Flück D, Morris LE, Niroula S, Tallon CM, Sherpa KT, Stembridge M, Ainslie PN, McManus AM.

J Appl Physiol (1985). 2017 Oct 1;123(4):1003-1010. doi: 10.1152/japplphysiol.00292.2017. Epub 2017 Jun 1.


Assessment of flow-mediated dilatation in the superficial femoral artery using a sustained shear stress stimulus via calf plantar-flexion exercise.

King TJ, Schmitter SM, Pyke KE.

Exp Physiol. 2017 Jun 1;102(6):725-737. doi: 10.1113/EP085980. Epub 2017 Mar 22.


Acute impact of retrograde shear rate on brachial and superficial femoral artery flow-mediated dilation in humans.

Schreuder TH, Green DJ, Hopman MT, Thijssen DH.

Physiol Rep. 2014 Jan 6;2(1):e00193. doi: 10.1002/phy2.193. eCollection 2014 Jan 1.


Retrograde shear rate in formerly preeclamptic and healthy women before and after exercise training: relationship with endothelial function.

Scholten RR, Spaanderman ME, Green DJ, Hopman MT, Thijssen DH.

Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H418-25. doi: 10.1152/ajpheart.00128.2014. Epub 2014 Jun 6.


Oxidative-nitrosative stress and systemic vascular function in highlanders with and without exaggerated hypoxemia.

Bailey DM, Rimoldi SF, Rexhaj E, Pratali L, Salinas Salmòn C, Villena M, McEneny J, Young IS, Nicod P, Allemann Y, Scherrer U, Sartori C.

Chest. 2013 Feb 1;143(2):444-451. doi: 10.1378/chest.12-0728.


Supraspinal Fatigue and Neural-evoked Responses in Lowlanders and Sherpa at 5050 m.

Ruggiero L, McNeil CJ.

Med Sci Sports Exerc. 2019 Jan;51(1):183-192. doi: 10.1249/MSS.0000000000001748.


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