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Items: 1 to 20 of 103


Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1.

Hankey W, Chen Z, Bergman MJ, Fernandez MO, Hancioglu B, Lan X, Jegga AG, Zhang J, Jin VX, Aronow BJ, Wang Q, Groden J.

Oncotarget. 2018 Jul 27;9(58):31214-31230. doi: 10.18632/oncotarget.25781. eCollection 2018 Jul 27.


Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting.

Hankey W, Frankel WL, Groden J.

Cancer Metastasis Rev. 2018 Mar;37(1):159-172. doi: 10.1007/s10555-017-9725-6. Review.


Identification of {beta}-catenin binding regions in colon cancer cells using ChIP-Seq.

Bottomly D, Kyler SL, McWeeney SK, Yochum GS.

Nucleic Acids Res. 2010 Sep;38(17):5735-45. doi: 10.1093/nar/gkq363. Epub 2010 May 11.


Mutational Mechanisms That Activate Wnt Signaling and Predict Outcomes in Colorectal Cancer Patients.

Hankey W, McIlhatton MA, Ebede K, Kennedy B, Hancioglu B, Zhang J, Brock GN, Huang K, Groden J.

Cancer Res. 2018 Feb 1;78(3):617-630. doi: 10.1158/0008-5472.CAN-17-1357. Epub 2017 Dec 6.


OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors.

Ye GD, Sun GB, Jiao P, Chen C, Liu QF, Huang XL, Zhang R, Cai WY, Li SN, Wu JF, Liu YJ, Wu RS, Xie YY, Chan EC, Liou YC, Li BA.

Gastroenterology. 2016 Mar;150(3):659-671.e16. doi: 10.1053/j.gastro.2015.11.041. Epub 2015 Nov 24.


A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression.

Zeineldin M, Cunningham J, McGuinness W, Alltizer P, Cowley B, Blanchat B, Xu W, Pinson D, Neufeld KL.

Oncogene. 2012 May 10;31(19):2423-37. doi: 10.1038/onc.2011.434. Epub 2011 Sep 26.


The Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cells.

Ungerbäck J, Elander N, Grünberg J, Sigvardsson M, Söderkvist P.

PLoS One. 2011 Mar 18;6(3):e17957. doi: 10.1371/journal.pone.0017957.


HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression.

Li Y, Bavarva JH, Wang Z, Guo J, Qian C, Thibodeau SN, Golemis EA, Liu W.

Oncogene. 2011 Jun 9;30(23):2633-43. doi: 10.1038/onc.2010.632. Epub 2011 Feb 14.


Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer.

Kim HA, Koo BK, Cho JH, Kim YY, Seong J, Chang HJ, Oh YM, Stange DE, Park JG, Hwang D, Kong YY.

J Clin Invest. 2012 Sep;122(9):3248-59. doi: 10.1172/JCI61216. Epub 2012 Aug 6.


Wnt/β-catenin signaling regulated SATB1 promotes colorectal cancer tumorigenesis and progression.

Mir R, Pradhan SJ, Patil P, Mulherkar R, Galande S.

Oncogene. 2016 Mar 31;35(13):1679-91. doi: 10.1038/onc.2015.232. Epub 2015 Jul 13.


Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer.

Masuda M, Sawa M, Yamada T.

Pharmacol Ther. 2015 Dec;156:1-9. doi: 10.1016/j.pharmthera.2015.10.009. Epub 2015 Nov 2. Review.


Integrative ChIP-seq/microarray analysis identifies a CTNNB1 target signature enriched in intestinal stem cells and colon cancer.

Watanabe K, Biesinger J, Salmans ML, Roberts BS, Arthur WT, Cleary M, Andersen B, Xie X, Dai X.

PLoS One. 2014 Mar 20;9(3):e92317. doi: 10.1371/journal.pone.0092317. eCollection 2014.


Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin.

Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, Means AL, Eschrich SA, Yeatman TJ, Deane NG, Beauchamp RD.

Gastroenterology. 2012 Mar;142(3):562-571.e2. doi: 10.1053/j.gastro.2011.11.026. Epub 2011 Nov 22.


α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes.

Choi SH, Estarás C, Moresco JJ, Yates JR 3rd, Jones KA.

Genes Dev. 2013 Nov 15;27(22):2473-88. doi: 10.1101/gad.229062.113.


The Yin-Yang of TCF/beta-catenin signaling.

Barker N, Morin PJ, Clevers H.

Adv Cancer Res. 2000;77:1-24. Review.


Expression of osteopontin, a target gene of de-regulated Wnt signaling, predicts survival in colon cancer.

Rohde F, Rimkus C, Friederichs J, Rosenberg R, Marthen C, Doll D, Holzmann B, Siewert JR, Janssen KP.

Int J Cancer. 2007 Oct 15;121(8):1717-23.


SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of β-catenin.

Lo YH, Noah TK, Chen MS, Zou W, Borras E, Vilar E, Shroyer NF.

Gastroenterology. 2017 Jul;153(1):205-218.e8. doi: 10.1053/j.gastro.2017.03.048. Epub 2017 Apr 5.


Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer.

Lemieux E, Cagnol S, Beaudry K, Carrier J, Rivard N.

Oncogene. 2015 Sep 17;34(38):4914-27. doi: 10.1038/onc.2014.416. Epub 2014 Dec 15.


The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.

Sierra J, Yoshida T, Joazeiro CA, Jones KA.

Genes Dev. 2006 Mar 1;20(5):586-600.

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