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Items: 1 to 20 of 103

1.

Neuronal subset-specific deletion of Pten results in aberrant Wnt signaling and memory impairments.

Hodges SL, Reynolds CD, Smith GD, Jefferson TS, Gao N, Morrison JB, White J, Nolan SO, Lugo JN.

Brain Res. 2018 Nov 15;1699:100-106. doi: 10.1016/j.brainres.2018.08.007. Epub 2018 Aug 4.

PMID:
30086265
2.

Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration.

Sperow M, Berry RB, Bayazitov IT, Zhu G, Baker SJ, Zakharenko SS.

J Physiol. 2012 Feb 15;590(4):777-92. doi: 10.1113/jphysiol.2011.220236. Epub 2011 Dec 6.

3.

Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins.

Lugo JN, Smith GD, Arbuckle EP, White J, Holley AJ, Floruta CM, Ahmed N, Gomez MC, Okonkwo O.

Front Mol Neurosci. 2014 Apr 16;7:27. doi: 10.3389/fnmol.2014.00027. eCollection 2014.

4.

Deletion of PTEN produces deficits in conditioned fear and increases fragile X mental retardation protein.

Lugo JN, Smith GD, Morrison JB, White J.

Learn Mem. 2013 Nov 15;20(12):670-3. doi: 10.1101/lm.032839.113.

PMID:
24241749
5.

Activation of PI3K/Akt/mTOR signaling pathway triggered by PTEN downregulation in the pathogenesis of Crohn's disease.

Long SH, He Y, Chen MH, Cao K, Chen YJ, Chen BL, Mao R, Zhang SH, Zhu ZH, Zeng ZR, Hu PJ.

J Dig Dis. 2013 Dec;14(12):662-9. doi: 10.1111/1751-2980.12095.

PMID:
23962154
6.

Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression.

Laguë MN, Paquet M, Fan HY, Kaartinen MJ, Chu S, Jamin SP, Behringer RR, Fuller PJ, Mitchell A, Doré M, Huneault LM, Richards JS, Boerboom D.

Carcinogenesis. 2008 Nov;29(11):2062-72. doi: 10.1093/carcin/bgn186. Epub 2008 Aug 6.

7.

Capillary Isoelectric Focusing of Akt Isoforms Identifies Highly Dynamic Phosphorylation in Neuronal Cells and Brain Tissue.

Schrötter S, Leondaritis G, Eickholt BJ.

J Biol Chem. 2016 May 6;291(19):10239-51. doi: 10.1074/jbc.M115.700138. Epub 2016 Mar 4.

8.

S6k1 is not required for Pten-deficient neuronal hypertrophy.

Chalhoub N, Kozma SC, Baker SJ.

Brain Res. 2006 Jul 19;1100(1):32-41. Epub 2006 Jun 13.

PMID:
16777079
9.

Self-reinforcing effects of mTOR hyperactive neurons on dendritic growth.

Arafa SR, LaSarge CL, Pun RYK, Khademi S, Danzer SC.

Exp Neurol. 2019 Jan;311:125-134. doi: 10.1016/j.expneurol.2018.09.019. Epub 2018 Sep 28.

PMID:
30268766
10.

Opisthorchis viverrini infection activates the PI3K/ AKT/PTEN and Wnt/β-catenin signaling pathways in a Cholangiocarcinogenesis model.

Yothaisong S, Thanee M, Namwat N, Yongvanit P, Boonmars T, Puapairoj A, Loilome W.

Asian Pac J Cancer Prev. 2014;15(23):10463-8.

11.

Molecular interplay between hyperactive mammalian target of rapamycin signaling and Alzheimer's disease neuropathology in the NS-Pten knockout mouse model.

Hodges SL, Reynolds CD, Smith GD, Jefferson TS, Nolan SO, Lugo JN.

Neuroreport. 2018 Sep 5;29(13):1109-1113. doi: 10.1097/WNR.0000000000001081.

12.

Neuronal deletion of phosphatase and tensin homolog results in cerebellar motor learning dysfunction and alterations in intracellular signaling.

Nolan SO, Jefferson TS, Reynolds CD, Smith GD, Holley AJ, Hodges SL, Lugo JN.

Neuroreport. 2019 May 22;30(8):556-561. doi: 10.1097/WNR.0000000000001241.

PMID:
30920436
13.

Intermittent fasting uncovers and rescues cognitive phenotypes in PTEN neuronal haploinsufficient mice.

Cabral-Costa JV, Andreotti DZ, Mello NP, Scavone C, Camandola S, Kawamoto EM.

Sci Rep. 2018 Jun 5;8(1):8595. doi: 10.1038/s41598-018-26814-6.

14.

TGF-β1 Restores Hippocampal Synaptic Plasticity and Memory in Alzheimer Model via the PI3K/Akt/Wnt/β-Catenin Signaling Pathway.

Hu Y, Chen W, Wu L, Jiang L, Liang N, Tan L, Liang M, Tang N.

J Mol Neurosci. 2019 Jan;67(1):142-149. doi: 10.1007/s12031-018-1219-7. Epub 2018 Dec 12.

PMID:
30539409
15.
16.

Development and characterization of NEX- Pten, a novel forebrain excitatory neuron-specific knockout mouse.

Kazdoba TM, Sunnen CN, Crowell B, Lee GH, Anderson AE, D'Arcangelo G.

Dev Neurosci. 2012;34(2-3):198-209. Epub 2012 May 8.

17.

Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages.

Luyendyk JP, Schabbauer GA, Tencati M, Holscher T, Pawlinski R, Mackman N.

J Immunol. 2008 Mar 15;180(6):4218-26.

18.

Differential roles for Akt and mTORC1 in the hypertrophy of Pten mutant neurons, a cellular model of brain overgrowth disorders.

Nikolaeva I, Kazdoba TM, Crowell B, D'Arcangelo G.

Neuroscience. 2017 Jun 23;354:196-207. doi: 10.1016/j.neuroscience.2017.04.026. Epub 2017 Apr 27.

PMID:
28457820
19.

PTEN deletion increases hippocampal granule cell excitability in male and female mice.

Santos VR, Pun RYK, Arafa SR, LaSarge CL, Rowley S, Khademi S, Bouley T, Holland KD, Garcia-Cairasco N, Danzer SC.

Neurobiol Dis. 2017 Dec;108:339-351. doi: 10.1016/j.nbd.2017.08.014. Epub 2017 Sep 21.

20.

Withdrawn

[No authors listed]

CNS Neurol Disord Drug Targets. 2019 Mar 12. [Epub ahead of print]

PMID:
30864513

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