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Items: 1 to 20 of 107

1.

Interactions between Macrophages and Cyst-Lining Epithelial Cells Promote Kidney Cyst Growth in Pkd1-Deficient Mice.

Yang Y, Chen M, Zhou J, Lv J, Song S, Fu L, Chen J, Yang M, Mei C.

J Am Soc Nephrol. 2018 Sep;29(9):2310-2325. doi: 10.1681/ASN.2018010074. Epub 2018 Jul 24.

2.

Macrophages promote polycystic kidney disease progression.

Swenson-Fields KI, Vivian CJ, Salah SM, Peda JD, Davis BM, van Rooijen N, Wallace DP, Fields TA.

Kidney Int. 2013 May;83(5):855-64. doi: 10.1038/ki.2012.446. Epub 2013 Feb 20.

3.

Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease.

Raman A, Parnell SC, Zhang Y, Reif GA, Dai Y, Khanna A, Daniel E, White C, Vivian JL, Wallace DP.

Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1695-F1707. doi: 10.1152/ajprenal.00246.2018. Epub 2018 Oct 17.

PMID:
30332313
4.

Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease.

Chen L, Zhou X, Fan LX, Yao Y, Swenson-Fields KI, Gadjeva M, Wallace DP, Peters DJ, Yu A, Grantham JJ, Li X.

J Clin Invest. 2015 Jun;125(6):2399-412. doi: 10.1172/JCI80467. Epub 2015 May 11.

5.

Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease.

Leonhard WN, Zandbergen M, Veraar K, van den Berg S, van der Weerd L, Breuning M, de Heer E, Peters DJ.

J Am Soc Nephrol. 2015 Jun;26(6):1322-33. doi: 10.1681/ASN.2013080864. Epub 2014 Oct 31.

6.

Mcp1 Promotes Macrophage-Dependent Cyst Expansion in Autosomal Dominant Polycystic Kidney Disease.

Cassini MF, Kakade VR, Kurtz E, Sulkowski P, Glazer P, Torres R, Somlo S, Cantley LG.

J Am Soc Nephrol. 2018 Oct;29(10):2471-2481. doi: 10.1681/ASN.2018050518. Epub 2018 Sep 12.

PMID:
30209078
7.

Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.

Li LX, Fan LX, Zhou JX, Grantham JJ, Calvet JP, Sage J, Li X.

J Clin Invest. 2017 Jun 30;127(7):2751-2764. doi: 10.1172/JCI90921. Epub 2017 Jun 12.

8.

Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.

Zhou X, Fan LX, Sweeney WE Jr, Denu JM, Avner ED, Li X.

J Clin Invest. 2013 Jul;123(7):3084-98. doi: 10.1172/JCI64401. Epub 2013 Jun 17.

9.

Cux1 promotes cell proliferation and polycystic kidney disease progression in an ADPKD mouse model.

Porath B, Livingston S, Andres EL, Petrie AM, Wright JC, Woo AE, Carlton CG, Baybutt R, Vanden Heuvel GB.

Am J Physiol Renal Physiol. 2017 Oct 1;313(4):F1050-F1059. doi: 10.1152/ajprenal.00380.2016. Epub 2017 Jul 12.

10.

Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease.

Cebotaru L, Liu Q, Yanda MK, Boinot C, Outeda P, Huso DL, Watnick T, Guggino WB, Cebotaru V.

Kidney Int. 2016 Jul;90(1):90-9. doi: 10.1016/j.kint.2016.01.026. Epub 2016 Mar 25.

11.

Role of keratinocyte growth factor in the pathogenesis of autosomal dominant polycystic kidney disease.

Mei C, Mao Z, Shen X, Wang W, Dai B, Tang B, Wu Y, Cao Y, Zhang S, Zhao H, Sun T.

Nephrol Dial Transplant. 2005 Nov;20(11):2368-75. Epub 2005 Sep 2.

PMID:
16141466
12.

Macrophages promote cyst growth in polycystic kidney disease.

Karihaloo A, Koraishy F, Huen SC, Lee Y, Merrick D, Caplan MJ, Somlo S, Cantley LG.

J Am Soc Nephrol. 2011 Oct;22(10):1809-14. doi: 10.1681/ASN.2011010084. Epub 2011 Sep 15.

13.

STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease.

Fragiadaki M, Lannoy M, Themanns M, Maurer B, Leonhard WN, Peters DJ, Moriggl R, Ong AC.

Kidney Int. 2017 Mar;91(3):575-586. doi: 10.1016/j.kint.2016.10.039. Epub 2017 Jan 16.

14.

Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD.

Leuenroth SJ, Bencivenga N, Chahboune H, Hyder F, Crews CM.

Nephrol Dial Transplant. 2010 Jul;25(7):2187-94. doi: 10.1093/ndt/gfp777. Epub 2010 Feb 4.

15.

Renal cyst growth is the main determinant for hypertension and concentrating deficit in Pkd1-deficient mice.

Fonseca JM, Bastos AP, Amaral AG, Sousa MF, Souza LE, Malheiros DM, Piontek K, Irigoyen MC, Watnick TJ, Onuchic LF.

Kidney Int. 2014 May;85(5):1137-50. doi: 10.1038/ki.2013.501. Epub 2014 Jan 15.

16.

Rosiglitazone inhibits insulin-like growth factor‑1-induced polycystic kidney disease cell growth and p70S6 kinase activation.

Liu C, Zhang Y, Yuan L, Fu L, Mei C.

Mol Med Rep. 2013 Sep;8(3):861-4. doi: 10.3892/mmr.2013.1588. Epub 2013 Jul 16.

PMID:
23864113
17.

Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease.

Peda JD, Salah SM, Wallace DP, Fields PE, Grantham CJ, Fields TA, Swenson-Fields KI.

Dis Model Mech. 2016 Sep 1;9(9):1051-61. doi: 10.1242/dmm.024745. Epub 2016 Aug 4.

18.

Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier.

Menezes LF, Zhou F, Patterson AD, Piontek KB, Krausz KW, Gonzalez FJ, Germino GG.

PLoS Genet. 2012;8(11):e1003053. doi: 10.1371/journal.pgen.1003053. Epub 2012 Nov 29.

19.

Integrin-Linked Kinase Signaling Promotes Cyst Growth and Fibrosis in Polycystic Kidney Disease.

Raman A, Reif GA, Dai Y, Khanna A, Li X, Astleford L, Parnell SC, Calvet JP, Wallace DP.

J Am Soc Nephrol. 2017 Sep;28(9):2708-2719. doi: 10.1681/ASN.2016111235. Epub 2017 May 18.

20.

Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.

Zhou X, Fan LX, Peters DJ, Trudel M, Bradner JE, Li X.

Hum Mol Genet. 2015 Jul 15;24(14):3982-93. doi: 10.1093/hmg/ddv136. Epub 2015 Apr 15.

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