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Items: 1 to 20 of 104

1.

A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase.

Freedman H, Winter P, Tuszynski J, Tyrrell DL, Houghton M.

J Biol Chem. 2018 Jun 22;293(25):9696-9705. doi: 10.1074/jbc.RA118.002588. Epub 2018 May 8.

PMID:
29739852
2.

Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides.

Arnold JJ, Sharma SD, Feng JY, Ray AS, Smidansky ED, Kireeva ML, Cho A, Perry J, Vela JE, Park Y, Xu Y, Tian Y, Babusis D, Barauskus O, Peterson BR, Gnatt A, Kashlev M, Zhong W, Cameron CE.

PLoS Pathog. 2012;8(11):e1003030. doi: 10.1371/journal.ppat.1003030. Epub 2012 Nov 15.

3.

Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs.

Jin Z, Kinkade A, Behera I, Chaudhuri S, Tucker K, Dyatkina N, Rajwanshi VK, Wang G, Jekle A, Smith DB, Beigelman L, Symons JA, Deval J.

Antiviral Res. 2017 Jul;143:151-161. doi: 10.1016/j.antiviral.2017.04.005. Epub 2017 Apr 12.

4.

Simple In Vitro Assay To Evaluate the Incorporation Efficiency of Ribonucleotide Analog 5'-Triphosphates into RNA by Human Mitochondrial DNA-Dependent RNA Polymerase.

Lu G, Bluemling GR, Mao S, Hager M, Gurale BP, Collop P, Kuiper D, Sana K, Painter GR, De La Rosa A, Kolykhalov AA.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01830-17. doi: 10.1128/AAC.01830-17. Print 2018 Feb.

5.

Human mitochondrial RNA polymerase: structure-function, mechanism and inhibition.

Arnold JJ, Smidansky ED, Moustafa IM, Cameron CE.

Biochim Biophys Acta. 2012 Sep-Oct;1819(9-10):948-60. doi: 10.1016/j.bbagrm.2012.04.002. Epub 2012 Apr 19. Review.

PMID:
22551784
6.

Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase.

Ehteshami M, Zhou L, Amiralaei S, Shelton JR, Cho JH, Zhang H, Li H, Lu X, Ozturk T, Stanton R, Amblard F, McBrayer TR, Coats SJ, Schinazi RF.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00492-17. doi: 10.1128/AAC.00492-17. Print 2017 Aug.

7.

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus.

Feng JY, Xu Y, Barauskas O, Perry JK, Ahmadyar S, Stepan G, Yu H, Babusis D, Park Y, McCutcheon K, Perron M, Schultz BE, Sakowicz R, Ray AS.

Antimicrob Agents Chemother. 2015 Nov 23;60(2):806-17. doi: 10.1128/AAC.01922-15. Print 2016 Feb.

8.

Modeling RNA polymerase interaction in mitochondria of chordates.

Lyubetsky VA, Zverkov OA, Pirogov SA, Rubanov LI, Seliverstov AV.

Biol Direct. 2012 Aug 9;7:26. doi: 10.1186/1745-6150-7-26.

9.

Transcriptional fidelities of human mitochondrial POLRMT, yeast mitochondrial Rpo41, and phage T7 single-subunit RNA polymerases.

Sultana S, Solotchi M, Ramachandran A, Patel SS.

J Biol Chem. 2017 Nov 3;292(44):18145-18160. doi: 10.1074/jbc.M117.797480. Epub 2017 Sep 7.

10.

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.

Ehteshami M, Tao S, Ozturk T, Zhou L, Cho JH, Zhang H, Amiralaei S, Shelton JR, Lu X, Khalil A, Domaoal RA, Stanton RA, Suesserman JE, Lin B, Lee SS, Amblard F, Whitaker T, Coats SJ, Schinazi RF.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4659-69. doi: 10.1128/AAC.00318-16. Print 2016 Aug.

11.

POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA.

Kühl I, Miranda M, Posse V, Milenkovic D, Mourier A, Siira SJ, Bonekamp NA, Neumann U, Filipovska A, Polosa PL, Gustafsson CM, Larsson NG.

Sci Adv. 2016 Aug 5;2(8):e1600963. doi: 10.1126/sciadv.1600963. eCollection 2016 Aug.

12.

Targeting mitochondrial RNA polymerase in acute myeloid leukemia.

Bralha FN, Liyanage SU, Hurren R, Wang X, Son MH, Fung TA, Chingcuanco FB, Tung AY, Andreazza AC, Psarianos P, Schimmer AD, Salmena L, Laposa RR.

Oncotarget. 2015 Nov 10;6(35):37216-28. doi: 10.18632/oncotarget.6129.

13.

Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis.

Surovtseva YV, Shadel GS.

Nucleic Acids Res. 2013 Feb 1;41(4):2479-88. doi: 10.1093/nar/gks1447. Epub 2013 Jan 8.

14.
15.

An all-atom, active site exploration of antiviral drugs that target Flaviviridae polymerases.

Valdés JJ, Gil VA, Butterill PT, Růžek D.

J Gen Virol. 2016 Oct;97(10):2552-2565. doi: 10.1099/jgv.0.000569. Epub 2016 Aug 1.

PMID:
27489039
16.

Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity Risk.

Fenaux M, Lin X, Yokokawa F, Sweeney Z, Saunders O, Xie L, Lim SP, Uteng M, Uehara K, Warne R, Gang W, Jones C, Yendluri S, Gu H, Mansfield K, Boisclair J, Heimbach T, Catoire A, Bracken K, Weaver M, Moser H, Zhong W.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7077-7085. Print 2016 Dec.

17.

Visualizing polynucleotide polymerase machines at work.

Steitz TA.

EMBO J. 2006 Aug 9;25(15):3458-68. Review.

18.

DNA conformation-dependent activities of human mitochondrial RNA polymerase.

Fukuoh A, Ohgaki K, Hatae H, Kuraoka I, Aoki Y, Uchiumi T, Jacobs HT, Kang D.

Genes Cells. 2009 Aug;14(8):1029-42. doi: 10.1111/j.1365-2443.2009.01328.x. Epub 2009 Jul 14.

19.

Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein.

Tagami S, Sekine S, Kumarevel T, Hino N, Murayama Y, Kamegamori S, Yamamoto M, Sakamoto K, Yokoyama S.

Nature. 2010 Dec 16;468(7326):978-82. doi: 10.1038/nature09573. Epub 2010 Dec 1.

PMID:
21124318
20.

The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription initiation.

Posse V, Hoberg E, Dierckx A, Shahzad S, Koolmeister C, Larsson NG, Wilhelmsson LM, Hällberg BM, Gustafsson CM.

Nucleic Acids Res. 2014 Apr;42(6):3638-47. doi: 10.1093/nar/gkt1397. Epub 2014 Jan 20.

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