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Items: 1 to 20 of 101

1.

Does N-terminal huntingtin function as a 'holdase' for inhibiting cellular protein aggregation?

Sethi R, Tripathi N, Pallapati AR, Gaikar A, Bharatam PV, Roy I.

FEBS J. 2018 May;285(10):1791-1811. doi: 10.1111/febs.14457. Epub 2018 May 8.

PMID:
29630769
2.

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation.

Peskett TR, Rau F, O'Driscoll J, Patani R, Lowe AR, Saibil HR.

Mol Cell. 2018 May 17;70(4):588-601.e6. doi: 10.1016/j.molcel.2018.04.007. Epub 2018 May 10.

3.

Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation.

Crick SL, Ruff KM, Garai K, Frieden C, Pappu RV.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20075-80. doi: 10.1073/pnas.1320626110. Epub 2013 Nov 26.

4.

Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core.

Lin HK, Boatz JC, Krabbendam IE, Kodali R, Hou Z, Wetzel R, Dolga AM, Poirier MA, van der Wel PCA.

Nat Commun. 2017 May 24;8:15462. doi: 10.1038/ncomms15462.

5.

Herp Promotes Degradation of Mutant Huntingtin: Involvement of the Proteasome and Molecular Chaperones.

Luo H, Cao L, Liang X, Du A, Peng T, Li H.

Mol Neurobiol. 2018 Oct;55(10):7652-7668. doi: 10.1007/s12035-018-0900-8. Epub 2018 Feb 12.

PMID:
29430620
6.

Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins.

Huang CC, Faber PW, Persichetti F, Mittal V, Vonsattel JP, MacDonald ME, Gusella JF.

Somat Cell Mol Genet. 1998 Jul;24(4):217-33.

PMID:
10410676
7.

The 17-residue-long N terminus in huntingtin controls stepwise aggregation in solution and on membranes via different mechanisms.

Pandey NK, Isas JM, Rawat A, Lee RV, Langen J, Pandey P, Langen R.

J Biol Chem. 2018 Feb 16;293(7):2597-2605. doi: 10.1074/jbc.M117.813667. Epub 2017 Dec 27.

8.

Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington's disease.

Chen M, Wolynes PG.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4406-4411. doi: 10.1073/pnas.1702237114. Epub 2017 Apr 11.

9.

Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors.

Banerjee M, Datta M, Bhattacharyya NP.

Int J Biochem Cell Biol. 2017 Jan;82:1-9. doi: 10.1016/j.biocel.2016.11.008. Epub 2016 Nov 10.

PMID:
27840155
10.

Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin.

Caron NS, Desmond CR, Xia J, Truant R.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14610-5. doi: 10.1073/pnas.1301342110. Epub 2013 Jul 29.

12.

N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion.

Chen MZ, Mok SA, Ormsby AR, Muchowski PJ, Hatters DM.

J Huntingtons Dis. 2017;6(1):79-91. doi: 10.3233/JHD-160207.

PMID:
28339398
13.

Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers.

Posey AE, Ruff KM, Harmon TS, Crick SL, Li A, Diamond MI, Pappu RV.

J Biol Chem. 2018 Mar 9;293(10):3734-3746. doi: 10.1074/jbc.RA117.000357. Epub 2018 Jan 22.

14.

Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences.

Lakhani VV, Ding F, Dokholyan NV.

PLoS Comput Biol. 2010 Apr 29;6(4):e1000772. doi: 10.1371/journal.pcbi.1000772.

15.

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.

Busch A, Engemann S, Lurz R, Okazawa H, Lehrach H, Wanker EE.

J Biol Chem. 2003 Oct 17;278(42):41452-61. Epub 2003 Jul 29.

16.
17.

Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models.

Daldin M, Fodale V, Cariulo C, Azzollini L, Verani M, Martufi P, Spiezia MC, Deguire SM, Cherubini M, Macdonald D, Weiss A, Bresciani A, Vonsattel JG, Petricca L, Marsh JL, Gines S, Santimone I, Marano M, Lashuel HA, Squitieri F, Caricasole A.

Sci Rep. 2017 Jul 11;7(1):5070. doi: 10.1038/s41598-017-05336-7.

18.

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation.

Zhou H, Li SH, Li XJ.

J Biol Chem. 2001 Dec 21;276(51):48417-24. Epub 2001 Oct 17.

19.

Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity.

Kvam E, Nannenga BL, Wang MS, Jia Z, Sierks MR, Messer A.

PLoS One. 2009 May 28;4(5):e5727. doi: 10.1371/journal.pone.0005727.

20.

Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties.

Mishra R, Hoop CL, Kodali R, Sahoo B, van der Wel PC, Wetzel R.

J Mol Biol. 2012 Nov 23;424(1-2):1-14. doi: 10.1016/j.jmb.2012.09.011. Epub 2012 Sep 18.

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