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Eukaryotic (translation) initiation factor 4A (eIF4A) inhibition may be used to treat Huntington's disease by decreasing the expression of huntingtin.

Webb TE.

Med Hypotheses. 2018 May;114:28. doi: 10.1016/j.mehy.2017.10.028. Epub 2017 Oct 31. No abstract available.


Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor.

Iwasaki S, Floor SN, Ingolia NT.

Nature. 2016 Jun 23;534(7608):558-61. doi: 10.1038/nature17978. Epub 2016 Jun 15.


The eukaryotic initiation factor (eIF) 4G HEAT domain promotes translation re-initiation in yeast both dependent on and independent of eIF4A mRNA helicase.

Watanabe R, Murai MJ, Singh CR, Fox S, Ii M, Asano K.

J Biol Chem. 2010 Jul 16;285(29):21922-33. doi: 10.1074/jbc.M110.132027. Epub 2010 May 12.


Unique translation initiation of mRNAs-containing TISU element.

Elfakess R, Sinvani H, Haimov O, Svitkin Y, Sonenberg N, Dikstein R.

Nucleic Acids Res. 2011 Sep 1;39(17):7598-609. doi: 10.1093/nar/gkr484. Epub 2011 Jun 25.


Evidence That Base-pairing Interaction between Intron and mRNA Leader Sequences Inhibits Initiation of HAC1 mRNA Translation in Yeast.

Sathe L, Bolinger C, Mannan MA, Dever TE, Dey M.

J Biol Chem. 2015 Sep 4;290(36):21821-32. doi: 10.1074/jbc.M115.649335. Epub 2015 Jul 14.


eIF4B stimulates translation of long mRNAs with structured 5' UTRs and low closed-loop potential but weak dependence on eIF4G.

Sen ND, Zhou F, Harris MS, Ingolia NT, Hinnebusch AG.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10464-72. doi: 10.1073/pnas.1612398113. Epub 2016 Sep 6.


The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure.

Svitkin YV, Pause A, Haghighat A, Pyronnet S, Witherell G, Belsham GJ, Sonenberg N.

RNA. 2001 Mar;7(3):382-94.


An upstream open reading frame impedes translation of the huntingtin gene.

Lee J, Park EH, Couture G, Harvey I, Garneau P, Pelletier J.

Nucleic Acids Res. 2002 Dec 1;30(23):5110-9.


[Potential open reading frames within 5'-untranslated regions of eukaryotic mRNAs].

Volkova OA, Kochetov AV, Titov SE, Kolchanov NA.

Biofizika. 2006 Jul-Aug;51(4):615-21. Russian.


mRNA helicases: the tacticians of translational control.

Parsyan A, Svitkin Y, Shahbazian D, Gkogkas C, Lasko P, Merrick WC, Sonenberg N.

Nat Rev Mol Cell Biol. 2011 Apr;12(4):235-45. doi: 10.1038/nrm3083. Review.


eIF4B stimulates eIF4A ATPase and unwinding activities by direct interaction through its 7-repeats region.

Andreou AZ, Harms U, Klostermeier D.

RNA Biol. 2017 Jan 2;14(1):113-123. doi: 10.1080/15476286.2016.1259782. Epub 2016 Nov 18.


Upstream open reading frames: molecular switches in (patho)physiology.

Wethmar K, Smink JJ, Leutz A.

Bioessays. 2010 Oct;32(10):885-93. doi: 10.1002/bies.201000037. Epub 2010 Aug 19. Review.


Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase.

Steinhardt JJ, Peroutka RJ, Mazan-Mamczarz K, Chen Q, Houng S, Robles C, Barth RN, DuBose J, Bruns B, Tesoriero R, Stein D, Fang R, Hanna N, Pasley J, Rodriguez C, Kligman MD, Bradley M, Rabin J, Shackelford S, Dai B, Landon AL, Scalea T, Livak F, Gartenhaus RB.

Blood. 2014 Dec 11;124(25):3758-67. doi: 10.1182/blood-2014-07-589689. Epub 2014 Oct 15.


Structural basis for translational inhibition by the tumour suppressor Pdcd4.

Loh PG, Yang HS, Walsh MA, Wang Q, Wang X, Cheng Z, Liu D, Song H.

EMBO J. 2009 Feb 4;28(3):274-85. doi: 10.1038/emboj.2008.278. Epub 2009 Jan 15.


The RNA Helicase eIF4A Is Required for Sapovirus Translation.

Hosmillo M, Sweeney TR, Chaudhry Y, Leen E, Curry S, Goodfellow I, Cho KO.

J Virol. 2016 Apr 29;90(10):5200-5204. doi: 10.1128/JVI.03174-15. Print 2016 May 15.


Interaction of translation initiation factor eIF4G with eIF4A in the yeast Saccharomyces cerevisiae.

Dominguez D, Altmann M, Benz J, Baumann U, Trachsel H.

J Biol Chem. 1999 Sep 17;274(38):26720-6.


Coupling of Translation Initiation and Termination Does Not Depend on the Mode of Initiation.

Sogorin EA, Selikhanov GK, Agalarov SC.

Biochemistry (Mosc). 2017 Jul;82(7):816-820. doi: 10.1134/S0006297917070069.

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