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Items: 1 to 20 of 101

1.

Inhibition of Hedgehog signaling suppresses proliferation and microcyst formation of human Autosomal Dominant Polycystic Kidney Disease cells.

Silva LM, Jacobs DT, Allard BA, Fields TA, Sharma M, Wallace DP, Tran PV.

Sci Rep. 2018 Mar 21;8(1):4985. doi: 10.1038/s41598-018-23341-2.

2.

Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.

Wang Q, Cobo-Stark P, Patel V, Somlo S, Han PL, Igarashi P.

Kidney Int. 2018 Feb;93(2):403-415. doi: 10.1016/j.kint.2017.08.005. Epub 2017 Oct 14.

3.

The regulatory 1α subunit of protein kinase A modulates renal cystogenesis.

Ye H, Wang X, Constans MM, Sussman CR, Chebib FT, Irazabal MV, Young WF Jr, Harris PC, Kirschner LS, Torres VE.

Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F677-F686. doi: 10.1152/ajprenal.00119.2017. Epub 2017 Jun 14.

4.

Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling.

Xu C, Rossetti S, Jiang L, Harris PC, Brown-Glaberman U, Wandinger-Ness A, Bacallao R, Alper SL.

Am J Physiol Renal Physiol. 2007 Mar;292(3):F930-45. Epub 2006 Nov 7.

5.

Ciliary Mechanisms of Cyst Formation in Polycystic Kidney Disease.

Ma M, Gallagher AR, Somlo S.

Cold Spring Harb Perspect Biol. 2017 Nov 1;9(11). pii: a028209. doi: 10.1101/cshperspect.a028209. Review.

PMID:
28320755
6.

Regulation of ciliary trafficking of polycystin-2 and the pathogenesis of autosomal dominant polycystic kidney disease.

Cai Y, Tang Z.

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Feb;35(2):93-9. doi: 10.3969/j.issn.1672-7347.2010.02.001. Review.

7.

Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction.

Nauli SM, Rossetti S, Kolb RJ, Alenghat FJ, Consugar MB, Harris PC, Ingber DE, Loghman-Adham M, Zhou J.

J Am Soc Nephrol. 2006 Apr;17(4):1015-25.

8.

Autosomal dominant polycystic kidney disease: recent advances in pathogenesis and potential therapies.

Mochizuki T, Tsuchiya K, Nitta K.

Clin Exp Nephrol. 2013 Jun;17(3):317-26. doi: 10.1007/s10157-012-0741-0. Epub 2012 Nov 29. Review.

PMID:
23192769
9.

Nedd9 restrains renal cystogenesis in Pkd1-/- mice.

Nikonova AS, Plotnikova OV, Serzhanova V, Efimov A, Bogush I, Cai KQ, Hensley HH, Egleston BL, Klein-Szanto A, Seeger-Nukpezah T, Golemis EA.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12859-64. doi: 10.1073/pnas.1405362111. Epub 2014 Aug 19.

10.

Cux1 promotes cell proliferation and polycystic kidney disease progression in an ADPKD mouse model.

Porath B, Livingston S, Andres EL, Petrie AM, Wright JC, Woo AE, Carlton CG, Baybutt R, Vanden Heuvel GB.

Am J Physiol Renal Physiol. 2017 Oct 1;313(4):F1050-F1059. doi: 10.1152/ajprenal.00380.2016. Epub 2017 Jul 12.

11.

Molecular advances in autosomal dominant polycystic kidney disease.

Gallagher AR, Germino GG, Somlo S.

Adv Chronic Kidney Dis. 2010 Mar;17(2):118-30. doi: 10.1053/j.ackd.2010.01.002. Review.

12.

Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease.

Ishimoto Y, Inagi R, Yoshihara D, Kugita M, Nagao S, Shimizu A, Takeda N, Wake M, Honda K, Zhou J, Nangaku M.

Mol Cell Biol. 2017 Nov 28;37(24). pii: e00337-17. doi: 10.1128/MCB.00337-17. Print 2017 Dec 15.

13.

Molecular basis of autosomal dominant polycystic kidney disease.

Al-Bhalal L, Akhtar M.

Adv Anat Pathol. 2005 May;12(3):126-33. Review.

PMID:
15900113
14.

Genetic Mechanisms of ADPKD.

Kim DY, Park JH.

Adv Exp Med Biol. 2016;933:13-22. Review.

PMID:
27730431
15.

Cell-Autonomous Hedgehog Signaling Is Not Required for Cyst Formation in Autosomal Dominant Polycystic Kidney Disease.

Ma M, Legué E, Tian X, Somlo S, Liem KF Jr.

J Am Soc Nephrol. 2019 Aug 26. pii: ASN.2018121274. doi: 10.1681/ASN.2018121274. [Epub ahead of print]

PMID:
31451534
16.

Cyst formation following disruption of intracellular calcium signaling.

Kuo IY, DesRochers TM, Kimmerling EP, Nguyen L, Ehrlich BE, Kaplan DL.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14283-8. doi: 10.1073/pnas.1412323111. Epub 2014 Sep 16.

17.

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway.

Hartman TR, Liu D, Zilfou JT, Robb V, Morrison T, Watnick T, Henske EP.

Hum Mol Genet. 2009 Jan 1;18(1):151-63. doi: 10.1093/hmg/ddn325. Epub 2008 Oct 9.

18.

A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease.

Li X, Magenheimer BS, Xia S, Johnson T, Wallace DP, Calvet JP, Li R.

Nat Med. 2008 Aug;14(8):863-8. doi: 10.1038/nm1783. Epub 2008 Jun 15.

19.

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

Park EY, Sung YH, Yang MH, Noh JY, Park SY, Lee TY, Yook YJ, Yoo KH, Roh KJ, Kim I, Hwang YH, Oh GT, Seong JK, Ahn C, Lee HW, Park JH.

J Biol Chem. 2009 Mar 13;284(11):7214-22. doi: 10.1074/jbc.M805890200. Epub 2008 Dec 20.

20.

Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model.

Leonhard WN, van der Wal A, Novalic Z, Kunnen SJ, Gansevoort RT, Breuning MH, de Heer E, Peters DJ.

Am J Physiol Renal Physiol. 2011 May;300(5):F1193-202. doi: 10.1152/ajprenal.00419.2010. Epub 2011 Feb 23.

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