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The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H.

EMBO J. 2018 Mar 15;37(6). pii: e99170. doi: 10.15252/embj.201899170. No abstract available.


The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H.

EMBO J. 2017 Feb 1;36(3):260-273. doi: 10.15252/embj.201694795. Epub 2016 Dec 22. Erratum in: EMBO J. 2018 Mar 15;37(6):.


STYX: a versatile pseudophosphatase.

Reiterer V, Pawłowski K, Farhan H.

Biochem Soc Trans. 2017 Apr 15;45(2):449-456. doi: 10.1042/BST20160279. Review.


The pseudophosphatase MK-STYX inhibits stress granule assembly independently of Ser149 phosphorylation of G3BP-1.

Barr JE, Munyikwa MR, Frazier EA, Hinton SD.

FEBS J. 2013 Jan;280(1):273-84. doi: 10.1111/febs.12068. Epub 2012 Dec 7.


Analyzing Pseudophosphatase Function.

Hinton SD.

Methods Mol Biol. 2016;1447:139-53. doi: 10.1007/978-1-4939-3746-2_9.


Pseudophosphatase as E3 ubiquitin ligase inhibitor.

Gough NR.

Sci Signal. 2017 Feb 14;10(466). pii: eaam9607. doi: 10.1126/scisignal.aam9607.


The pseudophosphatase MK-STYX induces neurite-like outgrowths in PC12 cells.

Flowers BM, Rusnak LE, Wong KE, Banks DA, Munyikwa MR, McFarland AG, Hinton SD.

PLoS One. 2014 Dec 5;9(12):e114535. doi: 10.1371/journal.pone.0114535. eCollection 2014.


The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation.

Hinton SD, Myers MP, Roggero VR, Allison LA, Tonks NK.

Biochem J. 2010 Apr 14;427(3):349-57. doi: 10.1042/BJ20091383.


Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2.

Reiterer V, Fey D, Kolch W, Kholodenko BN, Farhan H.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):E2934-43. doi: 10.1073/pnas.1301985110. Epub 2013 Jul 11.


Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal.

Kanatsu-Shinohara M, Onoyama I, Nakayama KI, Shinohara T.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8826-31. doi: 10.1073/pnas.1401837111. Epub 2014 May 30.


MK-STYX Alters the Morphology of Primary Neurons, and Outgrowths in MK-STYX Overexpressing PC-12 Cells Develop a Neuronal Phenotype.

Banks DA, Dahal A, McFarland AG, Flowers BM, Stephens CA, Swack B, Gugssa A, Anderson WA, Hinton SD.

Front Mol Biosci. 2017 Nov 16;4:76. doi: 10.3389/fmolb.2017.00076. eCollection 2017.


Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.

Onoyama I, Suzuki A, Matsumoto A, Tomita K, Katagiri H, Oike Y, Nakayama K, Nakayama KI.

J Clin Invest. 2011 Jan;121(1):342-54. doi: 10.1172/JCI40725. Epub 2010 Dec 1.


Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.

Pierce NW, Lee JE, Liu X, Sweredoski MJ, Graham RL, Larimore EA, Rome M, Zheng N, Clurman BE, Hess S, Shan SO, Deshaies RJ.

Cell. 2013 Mar 28;153(1):206-15. doi: 10.1016/j.cell.2013.02.024. Epub 2013 Feb 28.


The Fbxw7/hCdc4 tumor suppressor in human cancer.

Tan Y, Sangfelt O, Spruck C.

Cancer Lett. 2008 Nov 18;271(1):1-12. doi: 10.1016/j.canlet.2008.04.036. Epub 2008 Jun 9. Review.


The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1.

Niemi NM, Sacoman JL, Westrate LM, Gaither LA, Lanning NJ, Martin KR, MacKeigan JP.

PLoS One. 2014 Apr 7;9(4):e93896. doi: 10.1371/journal.pone.0093896. eCollection 2014.


Wnt/β-catenin signaling inhibits FBXW7 expression by upregulation of microRNA-770 in hepatocellular carcinoma.

Wu WJ, Shi J, Hu G, Yu X, Lu H, Yang ML, Liu B, Wu ZX.

Tumour Biol. 2016 May;37(5):6045-51. doi: 10.1007/s13277-015-4452-5. Epub 2015 Nov 24.


Distinct Interactions of EBP1 Isoforms with FBXW7 Elicits Different Functions in Cancer.

Wang Y, Zhang P, Wang Y, Zhan P, Liu C, Mao JH, Wei G.

Cancer Res. 2017 Apr 15;77(8):1983-1996. doi: 10.1158/0008-5472.CAN-16-2246. Epub 2017 Feb 16.


FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.

Babaei-Jadidi R, Li N, Saadeddin A, Spencer-Dene B, Jandke A, Muhammad B, Ibrahim EE, Muraleedharan R, Abuzinadah M, Davis H, Lewis A, Watson S, Behrens A, Tomlinson I, Nateri AS.

J Exp Med. 2011 Feb 14;208(2):295-312. doi: 10.1084/jem.20100830. Epub 2011 Jan 31.


Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation.

Fujii Y, Yada M, Nishiyama M, Kamura T, Takahashi H, Tsunematsu R, Susaki E, Nakagawa T, Matsumoto A, Nakayama KI.

Cancer Sci. 2006 Aug;97(8):729-36.


F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation.

Yumimoto K, Matsumoto M, Onoyama I, Imaizumi K, Nakayama KI.

J Biol Chem. 2013 Oct 4;288(40):28488-502. doi: 10.1074/jbc.M113.465179. Epub 2013 Aug 16.

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