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Items: 1 to 20 of 101

1.

Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures.

Monteiro O, Chen C, Bingham R, Argyrou A, Buxton R, Pancevac Jönsson C, Jones E, Bridges A, Gatfield K, Krauß S, Lambert J, Langston R, Schweiger S, Uings I.

Neurosci Lett. 2018 Apr 23;673:44-50. doi: 10.1016/j.neulet.2018.02.061. Epub 2018 Feb 27.

PMID:
29499308
2.

The MID1 E3 ligase catalyzes the polyubiquitination of Alpha4 (α4), a regulatory subunit of protein phosphatase 2A (PP2A): novel insights into MID1-mediated regulation of PP2A.

Du H, Huang Y, Zaghlula M, Walters E, Cox TC, Massiah MA.

J Biol Chem. 2013 Jul 19;288(29):21341-50. doi: 10.1074/jbc.M113.481093. Epub 2013 Jun 5.

3.

Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin.

Lin L, Jin Z, Tan H, Xu Q, Peng T, Li H.

Brain Res. 2016 Jul 15;1643:103-12. doi: 10.1016/j.brainres.2016.03.027. Epub 2016 Apr 21.

PMID:
27107943
4.

Differential proteomic and genomic profiling of mouse striatal cell model of Huntington's disease and control; probable implications to the disease biology.

Choudhury KR, Das S, Bhattacharyya NP.

J Proteomics. 2016 Jan 30;132:155-66. doi: 10.1016/j.jprot.2015.11.007. Epub 2015 Nov 12.

PMID:
26581643
5.

Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.

Krauss S, Griesche N, Jastrzebska E, Chen C, Rutschow D, Achmüller C, Dorn S, Boesch SM, Lalowski M, Wanker E, Schneider R, Schweiger S.

Nat Commun. 2013;4:1511. doi: 10.1038/ncomms2514.

PMID:
23443539
6.

Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease.

Pineda JR, Pardo R, Zala D, Yu H, Humbert S, Saudou F.

Mol Brain. 2009 Oct 27;2:33. doi: 10.1186/1756-6606-2-33.

7.

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.

Yin X, Manczak M, Reddy PH.

Hum Mol Genet. 2016 May 1;25(9):1739-53. doi: 10.1093/hmg/ddw045. Epub 2016 Feb 16.

8.

PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD).

Ratovitski T, Arbez N, Stewart JC, Chighladze E, Ross CA.

Cell Cycle. 2015;14(11):1716-29. doi: 10.1080/15384101.2015.1033595.

9.

Huntington's Disease Protein Huntingtin Associates with its own mRNA.

Culver BP, DeClercq J, Dolgalev I, Yu MS, Ma B, Heguy A, Tanese N.

J Huntingtons Dis. 2016;5(1):39-51. doi: 10.3233/JHD-150177.

10.

MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.

Du H, Wu K, Didoronkute A, Levy MV, Todi N, Shchelokova A, Massiah MA.

PLoS One. 2014 Sep 10;9(9):e107428. doi: 10.1371/journal.pone.0107428. eCollection 2014.

11.

The role of Twist1 in mutant huntingtin-induced transcriptional alterations and neurotoxicity.

Pan Y, Zhu Y, Yang W, Tycksen E, Liu S, Palucki J, Zhu L, Sasaki Y, Sharma MK, Kim AH, Zhang B, Yano H.

J Biol Chem. 2018 Jul 27;293(30):11850-11866. doi: 10.1074/jbc.RA117.001211. Epub 2018 Jun 11.

PMID:
29891550
12.

Beta catenin is regulated by its subcellular distribution and mutant huntingtin status in Huntington's disease cell STHdhQ111/HdhQ111.

Ghatak S, Raha S.

Biochem Biophys Res Commun. 2018 Sep 3;503(1):359-364. doi: 10.1016/j.bbrc.2018.06.034. Epub 2018 Jun 15.

PMID:
29894684
13.

Herp Promotes Degradation of Mutant Huntingtin: Involvement of the Proteasome and Molecular Chaperones.

Luo H, Cao L, Liang X, Du A, Peng T, Li H.

Mol Neurobiol. 2018 Oct;55(10):7652-7668. doi: 10.1007/s12035-018-0900-8. Epub 2018 Feb 12.

PMID:
29430620
14.

Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A.

Aranda-Orgillés B, Aigner J, Kunath M, Lurz R, Schneider R, Schweiger S.

PLoS One. 2008;3(10):e3507. doi: 10.1371/journal.pone.0003507. Epub 2008 Oct 24.

15.

Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.

Xifró X, Anglada-Huguet M, Rué L, Saavedra A, Pérez-Navarro E, Alberch J.

Mol Neurodegener. 2011 Oct 31;6:74. doi: 10.1186/1750-1326-6-74.

16.

Cellular Analysis of Silencing the Huntington's Disease Gene Using AAV9 Mediated Delivery of Artificial Micro RNA into the Striatum of Q140/Q140 Mice.

Keeler AM, Sapp E, Chase K, Sottosanti E, Danielson E, Pfister E, Stoica L, DiFiglia M, Aronin N, Sena-Esteves M.

J Huntingtons Dis. 2016 Oct 1;5(3):239-248.

PMID:
27689620
17.

MicroRNA-124 targets CCNA2 and regulates cell cycle in STHdh(Q111)/Hdh(Q111) cells.

Das E, Jana NR, Bhattacharyya NP.

Biochem Biophys Res Commun. 2013 Jul 26;437(2):217-24. doi: 10.1016/j.bbrc.2013.06.041. Epub 2013 Jun 21.

PMID:
23796713
18.

CRISPR-Cas9 Mediated Gene-Silencing of the Mutant Huntingtin Gene in an In Vitro Model of Huntington's Disease.

Kolli N, Lu M, Maiti P, Rossignol J, Dunbar GL.

Int J Mol Sci. 2017 Apr 2;18(4). pii: E754. doi: 10.3390/ijms18040754.

19.

Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C.

Peng C, Zhu G, Liu X, Li H.

Neurosci Bull. 2018 Oct;34(5):747-758. doi: 10.1007/s12264-018-0230-x. Epub 2018 Apr 30.

PMID:
29713895
20.

Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors.

Banerjee M, Datta M, Bhattacharyya NP.

Int J Biochem Cell Biol. 2017 Jan;82:1-9. doi: 10.1016/j.biocel.2016.11.008. Epub 2016 Nov 10.

PMID:
27840155

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