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i-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation.

Kwak M, Hong C, Myeong J, Park EYJ, Jeon JH, So I.

Sci Rep. 2018 Feb 22;8(1):3480. doi: 10.1038/s41598-018-21873-1.


The C-terminal tail of polycystin-1 regulates complement factor B expression by signal transducer and activator of transcription 1.

Wu M, Chen M, Jing Y, Gu J, Mei S, Yao Q, Zhou J, Yang M, Sun L, Wang W, Hu H, Wüthrich RP, Mei C.

Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1284-94. doi: 10.1152/ajprenal.00428.2015. Epub 2016 Mar 16.


Polycystin-1 regulates STAT activity by a dual mechanism.

Talbot JJ, Shillingford JM, Vasanth S, Doerr N, Mukherjee S, Kinter MT, Watnick T, Weimbs T.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7985-90. doi: 10.1073/pnas.1103816108. Epub 2011 Apr 25.


Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.

Jeon JP, Thakur DP, Tian JB, So I, Zhu MX.

Biochem J. 2016 May 15;473(10):1379-90. doi: 10.1042/BCJ20160214. Epub 2016 Mar 17.


A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD.

Parnell SC, Magenheimer BS, Maser RL, Pavlov TS, Havens MA, Hastings ML, Jackson SF, Ward CJ, Peterson KR, Staruschenko A, Calvet JP.

Hum Mol Genet. 2018 Oct 1;27(19):3313-3324. doi: 10.1093/hmg/ddy223.


Close spatio-association of the transient receptor potential canonical 4 (TRPC4) channel with Gαi in TRPC4 activation process.

Myeong J, Kwak M, Jeon JP, Hong C, Jeon JH, So I.

Am J Physiol Cell Physiol. 2015 Jun 1;308(11):C879-89. doi: 10.1152/ajpcell.00374.2014. Epub 2015 Mar 18.


Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1.

Foy RL, Chitalia VC, Panchenko MV, Zeng L, Lopez D, Lee JW, Rana SV, Boletta A, Qian F, Tsiokas L, Piontek KB, Germino GG, Zhou MI, Cohen HT.

Hum Mol Genet. 2012 Dec 15;21(26):5456-71. doi: 10.1093/hmg/dds391. Epub 2012 Sep 21.


Genetic Mechanisms of ADPKD.

Kim DY, Park JH.

Adv Exp Med Biol. 2016;933:13-22. Review.


A single amino acid residue constitutes the third dimerization domain essential for the assembly and function of the tetrameric polycystin-2 (TRPP2) channel.

Feng S, Rodat-Despoix L, Delmas P, Ong AC.

J Biol Chem. 2011 May 27;286(21):18994-9000. doi: 10.1074/jbc.M110.192286. Epub 2011 Apr 7.


Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels.

Thakur DP, Tian JB, Jeon J, Xiong J, Huang Y, Flockerzi V, Zhu MX.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1092-7. doi: 10.1073/pnas.1522294113. Epub 2016 Jan 11.


Activation of TRPC4β by Gαi subunit increases Ca2+ selectivity and controls neurite morphogenesis in cultured hippocampal neuron.

Jeon JP, Roh SE, Wie J, Kim J, Kim H, Lee KP, Yang D, Jeon JH, Cho NH, Kim IG, Kang DE, Kim HJ, So I.

Cell Calcium. 2013 Oct;54(4):307-19. doi: 10.1016/j.ceca.2013.07.006. Epub 2013 Aug 14.


Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the G protein-coupled receptor proteolytic site.

Chapin HC, Rajendran V, Caplan MJ.

Mol Biol Cell. 2010 Dec;21(24):4338-48. doi: 10.1091/mbc.E10-05-0407. Epub 2010 Oct 27.


Polycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathway.

Tang Y, Wang Z, Yang J, Zheng W, Chen D, Wu G, Sandford R, Tang J, Chen XZ.

Sci Rep. 2017 Sep 13;7(1):11493. doi: 10.1038/s41598-017-11526-0.


Regulation of Polycystin-1 Function by Calmodulin Binding.

Doerr N, Wang Y, Kipp KR, Liu G, Benza JJ, Pletnev V, Pavlov TS, Staruschenko A, Mohieldin AM, Takahashi M, Nauli SM, Weimbs T.

PLoS One. 2016 Aug 25;11(8):e0161525. doi: 10.1371/journal.pone.0161525. eCollection 2016.


Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling.

Xu C, Rossetti S, Jiang L, Harris PC, Brown-Glaberman U, Wandinger-Ness A, Bacallao R, Alper SL.

Am J Physiol Renal Physiol. 2007 Mar;292(3):F930-45. Epub 2006 Nov 7.


The cytoplasmic C-terminus of polycystin-1 increases cell proliferation in kidney epithelial cells through serum-activated and Ca(2+)-dependent pathway(s).

Manzati E, Aguiari G, Banzi M, Manzati M, Selvatici R, Falzarano S, Maestri I, Pinton P, Rizzuto R, del Senno L.

Exp Cell Res. 2005 Apr 1;304(2):391-406. Epub 2004 Dec 15.


Functional expression of calcium-permeable canonical transient receptor potential 4-containing channels promotes migration of medulloblastoma cells.

Wei WC, Huang WC, Lin YP, Becker EBE, Ansorge O, Flockerzi V, Conti D, Cenacchi G, Glitsch MD.

J Physiol. 2017 Aug 15;595(16):5525-5544. doi: 10.1113/JP274659. Epub 2017 Jul 20.


Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease.

Bastos AP, Onuchic LF.

Braz J Med Biol Res. 2011 Jul;44(7):606-17. Epub 2011 May 27. Review.


Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.

Streets AJ, Wessely O, Peters DJ, Ong AC.

Hum Mol Genet. 2013 May 15;22(10):1924-39. doi: 10.1093/hmg/ddt031. Epub 2013 Feb 5.


Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.

Fedeles SV, So JS, Shrikhande A, Lee SH, Gallagher AR, Barkauskas CE, Somlo S, Lee AH.

J Clin Invest. 2015 May;125(5):1955-67. doi: 10.1172/JCI78863. Epub 2015 Apr 6.

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