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Items: 1 to 20 of 103

1.

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation.

Ruff EF, Muretta JM, Thompson AR, Lake EW, Cyphers S, Albanese SK, Hanson SM, Behr JM, Thomas DD, Chodera JD, Levinson NM.

Elife. 2018 Feb 21;7. pii: e32766. doi: 10.7554/eLife.32766.

2.

A water-mediated allosteric network governs activation of Aurora kinase A.

Cyphers S, Ruff EF, Behr JM, Chodera JD, Levinson NM.

Nat Chem Biol. 2017 Apr;13(4):402-408. doi: 10.1038/nchembio.2296. Epub 2017 Feb 6.

3.

HRD Motif as the Central Hub of the Signaling Network for Activation Loop Autophosphorylation in Abl Kinase.

La Sala G, Riccardi L, Gaspari R, Cavalli A, Hantschel O, De Vivo M.

J Chem Theory Comput. 2016 Nov 8;12(11):5563-5574. Epub 2016 Oct 11.

PMID:
27682200
4.

Insights into MAPK p38alpha DFG flip mechanism by accelerated molecular dynamics.

Filomia F, De Rienzo F, Menziani MC.

Bioorg Med Chem. 2010 Sep 15;18(18):6805-12. doi: 10.1016/j.bmc.2010.07.047. Epub 2010 Jul 29.

PMID:
20724167
5.

The multifaceted allosteric regulation of Aurora kinase A.

Levinson NM.

Biochem J. 2018 Jun 26;475(12):2025-2042. doi: 10.1042/BCJ20170771. Review.

6.

Allosteric inhibition of c-Met kinase in sub-microsecond molecular dynamics simulations induced by its inhibitor, tivantinib.

Yan M, Wang H, Wang Q, Zhang Z, Zhang C.

Phys Chem Chem Phys. 2016 Apr 21;18(15):10367-74. doi: 10.1039/c5cp07001e. Epub 2016 Mar 31.

PMID:
27029952
7.

A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A.

Martin MP, Zhu JY, Lawrence HR, Pireddu R, Luo Y, Alam R, Ozcan S, Sebti SM, Lawrence NJ, Schönbrunn E.

ACS Chem Biol. 2012 Apr 20;7(4):698-706. doi: 10.1021/cb200508b. Epub 2012 Jan 27.

8.

Dynamics of human protein kinase Aurora A linked to drug selectivity.

Pitsawong W, Buosi V, Otten R, Agafonov RV, Zorba A, Kern N, Kutter S, Kern G, Pádua RA, Meniche X, Kern D.

Elife. 2018 Jun 14;7. pii: e36656. doi: 10.7554/eLife.36656.

9.

Human p38α Mitogen-Activated Protein Kinase in the Asp168-Phe169-Gly170-in (DFG-in) state can bind allosteric inhibitor Doramapimod.

Suplatov D, Kopylov K, Sharapova Y, Švedas V.

J Biomol Struct Dyn. 2018 May 11:1-35. doi: 10.1080/07391102.2018.1475260. [Epub ahead of print]

PMID:
29749295
10.

Molecular dynamics simulations show that conformational selection governs the binding preferences of imatinib for several tyrosine kinases.

Aleksandrov A, Simonson T.

J Biol Chem. 2010 Apr 30;285(18):13807-15. doi: 10.1074/jbc.M110.109660. Epub 2010 Mar 3.

11.

Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state.

Bukhtiyarova M, Karpusas M, Northrop K, Namboodiri HV, Springman EB.

Biochemistry. 2007 May 15;46(19):5687-96. Epub 2007 Apr 19.

PMID:
17441692
12.

Molecular mechanism of D816X mutation-induced c-Kit activation and -mediated inhibitor resistance in gastrointestinal stromal tumor.

Jiang H, Shao W, Wang Y, Xu R, Zhou L, Mu X.

J Mol Graph Model. 2018 Sep;84:189-196. doi: 10.1016/j.jmgm.2018.07.003. Epub 2018 Jul 10.

PMID:
30015051
13.
14.

Bitopic Inhibition of ATP and Substrate Binding in Ser/Thr Kinases through a Conserved Allosteric Mechanism.

Ma N, Lippert LG, Devamani T, Levy B, Lee S, Sandhu M, Vaidehi N, Sivaramakrishnan S.

Biochemistry. 2018 Nov 13;57(45):6387-6390. doi: 10.1021/acs.biochem.8b00729. Epub 2018 Oct 30.

PMID:
30339352
15.

Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy.

Gilburt JAH, Sarkar H, Sheldrake P, Blagg J, Ying L, Dodson CA.

Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11409-11414. doi: 10.1002/anie.201704654. Epub 2017 Aug 7.

16.

Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases.

Oruganty K, Talathi NS, Wood ZA, Kannan N.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):924-9. doi: 10.1073/pnas.1207104110. Epub 2012 Dec 31.

17.

The structure of C290A:C393A Aurora A provides structural insights into kinase regulation.

Burgess SG, Bayliss R.

Acta Crystallogr F Struct Biol Commun. 2015 Mar;71(Pt 3):315-9. doi: 10.1107/S2053230X15002290. Epub 2015 Feb 19.

18.

Emerging issues of connexin channels: biophysics fills the gap.

Harris AL.

Q Rev Biophys. 2001 Aug;34(3):325-472. Review. Erratum in: Q Rev Biophys 2002 Feb;35(1):109.

PMID:
11838236
19.

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.

Zeng K, Bastos RN, Barr FA, Gruneberg U.

J Cell Biol. 2010 Dec 27;191(7):1315-32. doi: 10.1083/jcb.201008106.

20.

Locking the active conformation of c-Src kinase through the phosphorylation of the activation loop.

Meng Y, Roux B.

J Mol Biol. 2014 Jan 23;426(2):423-35. doi: 10.1016/j.jmb.2013.10.001. Epub 2013 Oct 6.

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