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Items: 1 to 20 of 145

1.

Genetic and pharmacologic abrogation of Snail1 inhibits acinar-to-ductal metaplasia in precursor lesions of pancreatic ductal adenocarcinoma and pancreatic injury.

Fendrich V, Jendryschek F, Beeck S, Albers M, Lauth M, Esni F, Heeger K, Dengler J, Slater EP, Holler JPN, Baier A, Bartsch DK, Waldmann J.

Oncogene. 2018 Apr;37(14):1845-1856. doi: 10.1038/s41388-017-0100-4. Epub 2018 Jan 25.

PMID:
29367759
2.

Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice.

He P, Yang JW, Yang VW, Bialkowska AB.

Gastroenterology. 2018 Apr;154(5):1494-1508.e13. doi: 10.1053/j.gastro.2017.12.005. Epub 2017 Dec 15.

3.

Loss of Activin Receptor Type 1B Accelerates Development of Intraductal Papillary Mucinous Neoplasms in Mice With Activated KRAS.

Qiu W, Tang SM, Lee S, Turk AT, Sireci AN, Qiu A, Rose C, Xie C, Kitajewski J, Wen HJ, Crawford HC, Sims PA, Hruban RH, Remotti HE, Su GH.

Gastroenterology. 2016 Jan;150(1):218-228.e12. doi: 10.1053/j.gastro.2015.09.013. Epub 2015 Sep 25.

4.

RAGE gene deletion inhibits the development and progression of ductal neoplasia and prolongs survival in a murine model of pancreatic cancer.

DiNorcia J, Lee MK, Moroziewicz DN, Winner M, Suman P, Bao F, Remotti HE, Zou YS, Yan SF, Qiu W, Su GH, Schmidt AM, Allendorf JD.

J Gastrointest Surg. 2012 Jan;16(1):104-12; discussion 112. doi: 10.1007/s11605-011-1754-9. Epub 2011 Nov 4.

5.

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

Chen NM, Singh G, Koenig A, Liou GY, Storz P, Zhang JS, Regul L, Nagarajan S, Kühnemuth B, Johnsen SA, Hebrok M, Siveke J, Billadeau DD, Ellenrieder V, Hessmann E.

Gastroenterology. 2015 May;148(5):1024-1034.e9. doi: 10.1053/j.gastro.2015.01.033. Epub 2015 Jan 23.

6.

The epidermal growth factor receptor inhibitor gefitinib prevents the progression of pancreatic lesions to carcinoma in a conditional LSL-KrasG12D/+ transgenic mouse model.

Mohammed A, Janakiram NB, Li Q, Madka V, Ely M, Lightfoot S, Crawford H, Steele VE, Rao CV.

Cancer Prev Res (Phila). 2010 Nov;3(11):1417-26. doi: 10.1158/1940-6207.CAPR-10-0038.

7.

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

Hermann PC, Sancho P, Cañamero M, Martinelli P, Madriles F, Michl P, Gress T, de Pascual R, Gandia L, Guerra C, Barbacid M, Wagner M, Vieira CR, Aicher A, Real FX, Sainz B Jr, Heeschen C.

Gastroenterology. 2014 Nov;147(5):1119-33.e4. doi: 10.1053/j.gastro.2014.08.002. Epub 2014 Aug 12.

PMID:
25127677
8.

Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues.

Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P, Bartsch DK, Langer P, Chiblak S, Dürr A, Höfler H, Klöppel G, Müller-Decker K, Brielmeier M, Esposito I.

J Pathol. 2012 Apr;226(5):723-34. doi: 10.1002/path.3017. Epub 2012 Jan 17.

PMID:
21984419
9.

Expression of neuropeptide Y and its receptors Y1 and Y2 in pancreatic intraepithelial neoplasia and invasive pancreatic cancer in a transgenic mouse model and human samples of pancreatic cancer.

Waldmann J, Fendrich V, Reichert M, Hecker A, Bartsch DK, Padberg W, Holler JPN.

J Surg Res. 2018 Mar;223:230-236. doi: 10.1016/j.jss.2017.11.010. Epub 2017 Dec 22.

PMID:
29433879
10.

Simvastatin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer.

Fendrich V, Sparn M, Lauth M, Knoop R, Plassmeier L, Bartsch DK, Waldmann J.

Pancreatology. 2013 Sep-Oct;13(5):502-7. doi: 10.1016/j.pan.2013.08.002. Epub 2013 Aug 20.

PMID:
24075515
11.

Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia.

Zhu L, Shi G, Schmidt CM, Hruban RH, Konieczny SF.

Am J Pathol. 2007 Jul;171(1):263-73.

12.

A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice.

Philip B, Roland CL, Daniluk J, Liu Y, Chatterjee D, Gomez SB, Ji B, Huang H, Wang H, Fleming JB, Logsdon CD, Cruz-Monserrate Z.

Gastroenterology. 2013 Dec;145(6):1449-58. doi: 10.1053/j.gastro.2013.08.018. Epub 2013 Aug 16.

13.

Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor.

Funahashi H, Satake M, Dawson D, Huynh NA, Reber HA, Hines OJ, Eibl G.

Cancer Res. 2007 Aug 1;67(15):7068-71. Epub 2007 Jul 24.

14.

Identification and manipulation of biliary metaplasia in pancreatic tumors.

Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC.

Gastroenterology. 2014 Jan;146(1):233-44.e5. doi: 10.1053/j.gastro.2013.08.053. Epub 2013 Aug 30.

15.

Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia.

Shi G, DiRenzo D, Qu C, Barney D, Miley D, Konieczny SF.

Oncogene. 2013 Apr 11;32(15):1950-8. doi: 10.1038/onc.2012.210. Epub 2012 Jun 4.

16.

Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in Fat-1-p48(Cre/+)-LSL-Kras(G12D/+) mice.

Mohammed A, Janakiram NB, Brewer M, Duff A, Lightfoot S, Brush RS, Anderson RE, Rao CV.

Neoplasia. 2012 Dec;14(12):1249-59.

17.

The biological features of PanIN initiated from oncogenic Kras mutation in genetically engineered mouse models.

Shen R, Wang Q, Cheng S, Liu T, Jiang H, Zhu J, Wu Y, Wang L.

Cancer Lett. 2013 Oct 1;339(1):135-43. doi: 10.1016/j.canlet.2013.07.010. Epub 2013 Jul 22.

18.

GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice.

Shen J, Ha DP, Zhu G, Rangel DF, Kobielak A, Gill PS, Groshen S, Dubeau L, Lee AS.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4020-E4029. doi: 10.1073/pnas.1616060114. Epub 2017 May 1.

19.

Atorvastatin inhibits pancreatic carcinogenesis and increases survival in LSL-KrasG12D-LSL-Trp53R172H-Pdx1-Cre mice.

Liao J, Chung YT, Yang AL, Zhang M, Li H, Zhang W, Yan L, Yang GY.

Mol Carcinog. 2013 Sep;52(9):739-50. doi: 10.1002/mc.21916. Epub 2012 Apr 30.

20.

Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia.

Ding L, Liou GY, Schmitt DM, Storz P, Zhang JS, Billadeau DD.

J Pathol. 2017 Sep;243(1):65-77. doi: 10.1002/path.4928. Epub 2017 Jul 27.

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