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Items: 1 to 20 of 91

1.

Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models.

Zimmerman MI, Hart KM, Sibbald CA, Frederick TE, Jimah JR, Knoverek CR, Tolia NH, Bowman GR.

ACS Cent Sci. 2017 Dec 27;3(12):1311-1321. doi: 10.1021/acscentsci.7b00465. Epub 2017 Nov 21.

2.

A secondary drug resistance mutation of TEM-1 beta-lactamase that suppresses misfolding and aggregation.

Sideraki V, Huang W, Palzkill T, Gilbert HF.

Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):283-8.

3.

A natural polymorphism in beta-lactamase is a global suppressor.

Huang W, Palzkill T.

Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8801-6.

4.

Modelling proteins' hidden conformations to predict antibiotic resistance.

Hart KM, Ho CM, Dutta S, Gross ML, Bowman GR.

Nat Commun. 2016 Oct 6;7:12965. doi: 10.1038/ncomms12965.

5.

Increased folding stability of TEM-1 beta-lactamase by in vitro selection.

Kather I, Jakob RP, Dobbek H, Schmid FX.

J Mol Biol. 2008 Oct 31;383(1):238-51. doi: 10.1016/j.jmb.2008.07.082. Epub 2008 Aug 3.

PMID:
18706424
6.

[Investigation the role of mutations M182T and Q39K in structure of beta-lactamase TEM-72 by molecular dynamics method].

Shcherbinin DS, Rubtsova MY, Grigorenko VG, Uporov IV, Veselovsky AV, Egorov AM.

Biomed Khim. 2016 Jul;62(5):527-534. doi: 10.18097/PBMC20166205527. Russian.

PMID:
27797327
7.

SHV-129: A Gateway to Global Suppressors in the SHV β-Lactamase Family?

Winkler ML, Bonomo RA.

Mol Biol Evol. 2016 Feb;33(2):429-41. doi: 10.1093/molbev/msv235. Epub 2015 Nov 3.

8.

Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.

Dellus-Gur E, Elias M, Caselli E, Prati F, Salverda ML, de Visser JA, Fraser JS, Tawfik DS.

J Mol Biol. 2015 Jul 17;427(14):2396-409. doi: 10.1016/j.jmb.2015.05.011. Epub 2015 May 22.

9.

Predicting the emergence of antibiotic resistance by directed evolution and structural analysis.

Orencia MC, Yoon JS, Ness JE, Stemmer WP, Stevens RC.

Nat Struct Biol. 2001 Mar;8(3):238-42.

PMID:
11224569
10.

Multiple global suppressors of protein stability defects facilitate the evolution of extended-spectrum TEM β-lactamases.

Brown NG, Pennington JM, Huang W, Ayvaz T, Palzkill T.

J Mol Biol. 2010 Dec 17;404(5):832-46. doi: 10.1016/j.jmb.2010.10.008. Epub 2010 Oct 16.

11.

Capturing the mutational landscape of the beta-lactamase TEM-1.

Jacquier H, Birgy A, Le Nagard H, Mechulam Y, Schmitt E, Glodt J, Bercot B, Petit E, Poulain J, Barnaud G, Gros PA, Tenaillon O.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13067-72. doi: 10.1073/pnas.1215206110. Epub 2013 Jul 22.

12.

Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 beta-lactamase.

Marciano DC, Pennington JM, Wang X, Wang J, Chen Y, Thomas VL, Shoichet BK, Palzkill T.

J Mol Biol. 2008 Dec 5;384(1):151-64. doi: 10.1016/j.jmb.2008.09.009. Epub 2008 Sep 16.

13.

Markov state models provide insights into dynamic modulation of protein function.

Shukla D, Hernández CX, Weber JK, Pande VS.

Acc Chem Res. 2015 Feb 17;48(2):414-22. doi: 10.1021/ar5002999. Epub 2015 Jan 3. Review.

14.

Characterization of the global stabilizing substitution A77V and its role in the evolution of CTX-M β-lactamases.

Patel MP, Fryszczyn BG, Palzkill T.

Antimicrob Agents Chemother. 2015 Nov;59(11):6741-8. doi: 10.1128/AAC.00618-15. Epub 2015 Aug 17.

15.

The evolution of cefotaximase activity in the TEM β-lactamase.

Singh MK, Dominy BN.

J Mol Biol. 2012 Jan 6;415(1):205-20. doi: 10.1016/j.jmb.2011.10.041. Epub 2011 Nov 3.

PMID:
22075446
17.

Shifting Fitness and Epistatic Landscapes Reflect Trade-offs along an Evolutionary Pathway.

Steinberg B, Ostermeier M.

J Mol Biol. 2016 Jul 3;428(13):2730-43. doi: 10.1016/j.jmb.2016.04.033. Epub 2016 May 10.

PMID:
27173379
18.

Quantifying the adaptive potential of an antibiotic resistance enzyme.

Schenk MF, Szendro IG, Krug J, de Visser JA.

PLoS Genet. 2012 Jun;8(6):e1002783. doi: 10.1371/journal.pgen.1002783. Epub 2012 Jun 28.

19.

The structural bases of antibiotic resistance in the clinically derived mutant beta-lactamases TEM-30, TEM-32, and TEM-34.

Wang X, Minasov G, Shoichet BK.

J Biol Chem. 2002 Aug 30;277(35):32149-56. Epub 2002 Jun 10.

20.

Natural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevance.

Salverda ML, De Visser JA, Barlow M.

FEMS Microbiol Rev. 2010 Nov;34(6):1015-36. doi: 10.1111/j.1574-6976.2010.00222.x. Review.

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