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Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington's disease model.

Reynolds RH, Petersen MH, Willert CW, Heinrich M, Nymann N, Dall M, Treebak JT, Björkqvist M, Silahtaroglu A, Hasholt L, Nørremølle A.

Mol Cell Neurosci. 2018 Apr;88:118-129. doi: 10.1016/j.mcn.2017.12.009. Epub 2017 Dec 28.


miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease.

Castro RE, Ferreira DM, Afonso MB, Borralho PM, Machado MV, Cortez-Pinto H, Rodrigues CM.

J Hepatol. 2013 Jan;58(1):119-25. doi: 10.1016/j.jhep.2012.08.008. Epub 2012 Aug 15.


miR-34a repression of SIRT1 regulates apoptosis.

Yamakuchi M, Ferlito M, Lowenstein CJ.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13421-6. doi: 10.1073/pnas.0801613105. Epub 2008 Aug 28.


Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents.

Do MT, Kim HG, Choi JH, Jeong HG.

Free Radic Biol Med. 2014 Sep;74:21-34. doi: 10.1016/j.freeradbiomed.2014.06.010. Epub 2014 Jun 24.


Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway.

Kim HJ, Joe Y, Yu JK, Chen Y, Jeong SO, Mani N, Cho GJ, Pae HO, Ryter SW, Chung HT.

Biochim Biophys Acta. 2015 Jul;1852(7):1550-9. doi: 10.1016/j.bbadis.2015.04.017. Epub 2015 Apr 23.


c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver.

Ferreira DM, Afonso MB, Rodrigues PM, Simão AL, Pereira DM, Borralho PM, Rodrigues CM, Castro RE.

Mol Cell Biol. 2014 Mar;34(6):1100-20. doi: 10.1128/MCB.00420-13. Epub 2014 Jan 13.


MicroRNA-34a: a novel tumor suppressor in p53-mutant glioma cell line U251.

Luan S, Sun L, Huang F.

Arch Med Res. 2010 Feb;41(2):67-74. doi: 10.1016/j.arcmed.2010.02.007.


Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs.

Tian XF, Ji FJ, Zang HL, Cao H.

PLoS One. 2016 Jul 7;11(7):e0158657. doi: 10.1371/journal.pone.0158657. eCollection 2016.


SIRT1 inhibition restores apoptotic sensitivity in p53-mutated human keratinocytes.

Herbert KJ, Cook AL, Snow ET.

Toxicol Appl Pharmacol. 2014 Jun 15;277(3):288-97. doi: 10.1016/j.taap.2014.04.001. Epub 2014 Apr 12.


A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition.

Lee J, Padhye A, Sharma A, Song G, Miao J, Mo YY, Wang L, Kemper JK.

J Biol Chem. 2010 Apr 23;285(17):12604-11. doi: 10.1074/jbc.M109.094524. Epub 2010 Feb 25.


5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-Sirt1 axis.

Hu Z, Fan H, Lv G, Zhou Q, Yang B, Zheng J, Cao W.

J Dermatol Sci. 2015 Aug;79(2):155-62. doi: 10.1016/j.jdermsci.2015.04.010. Epub 2015 May 1.


0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop.

Xia C, Shui L, Lou G, Ye B, Zhu W, Wang J, Wu S, Xu X, Mao L, Xu W, Chen Z, Liu Y, Zheng M.

Sci Rep. 2017 Jun 30;7(1):4396. doi: 10.1038/s41598-017-04487-x.


The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis.

Lou G, Liu Y, Wu S, Xue J, Yang F, Fu H, Zheng M, Chen Z.

Cell Physiol Biochem. 2015;35(6):2192-202. doi: 10.1159/000374024. Epub 2015 Apr 7.


Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss.

Xiong H, Pang J, Yang H, Dai M, Liu Y, Ou Y, Huang Q, Chen S, Zhang Z, Xu Y, Lai L, Zheng Y.

Neurobiol Aging. 2015 Apr;36(4):1692-1701. doi: 10.1016/j.neurobiolaging.2014.12.034. Epub 2015 Jan 6.


MiR-34a inhibits migration and invasion by regulating the SIRT1/p53 pathway in human SW480 cells.

Lai M, Du G, Shi R, Yao J, Yang G, Wei Y, Zhang D, Xu Z, Zhang R, Li Y, Li Z, Wang L.

Mol Med Rep. 2015 May;11(5):3301-7. doi: 10.3892/mmr.2015.3182. Epub 2015 Jan 12.


MiR-34, SIRT1 and p53: the feedback loop.

Yamakuchi M, Lowenstein CJ.

Cell Cycle. 2009 Mar 1;8(5):712-5. Epub 2009 Mar 2.


MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis.

Yan S, Wang M, Zhao J, Zhang H, Zhou C, Jin L, Zhang Y, Qiu X, Ma B, Fan Q.

Int J Mol Med. 2016 Jul;38(1):201-9. doi: 10.3892/ijmm.2016.2618. Epub 2016 May 31.


Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.

Jeong H, Cohen DE, Cui L, Supinski A, Savas JN, Mazzulli JR, Yates JR 3rd, Bordone L, Guarente L, Krainc D.

Nat Med. 2011 Dec 18;18(1):159-65. doi: 10.1038/nm.2559.


Long non-coding RNA HNF1A-AS1 mediated repression of miR-34a/SIRT1/p53 feedback loop promotes the metastatic progression of colon cancer by functioning as a competing endogenous RNA.

Fang C, Qiu S, Sun F, Li W, Wang Z, Yue B, Wu X, Yan D.

Cancer Lett. 2017 Dec 1;410:50-62. doi: 10.1016/j.canlet.2017.09.012. Epub 2017 Sep 21.


miR-34a regulates mouse neural stem cell differentiation.

Aranha MM, Santos DM, Solá S, Steer CJ, Rodrigues CM.

PLoS One. 2011;6(8):e21396. doi: 10.1371/journal.pone.0021396. Epub 2011 Aug 3.

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