Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 103

1.

The 17-residue-long N terminus in huntingtin controls stepwise aggregation in solution and on membranes via different mechanisms.

Pandey NK, Isas JM, Rawat A, Lee RV, Langen J, Pandey P, Langen R.

J Biol Chem. 2018 Feb 16;293(7):2597-2605. doi: 10.1074/jbc.M117.813667. Epub 2017 Dec 27.

PMID:
29282287
2.

An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation.

Vieweg S, Ansaloni A, Wang ZM, Warner JB, Lashuel HA.

J Biol Chem. 2016 Jun 3;291(23):12074-86. doi: 10.1074/jbc.M116.713982. Epub 2016 Mar 21.

3.

Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington's disease.

Chen M, Wolynes PG.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4406-4411. doi: 10.1073/pnas.1702237114. Epub 2017 Apr 11.

4.
5.

Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.

Branco-Santos J, Herrera F, Poças GM, Pires-Afonso Y, Giorgini F, Domingos PM, Outeiro TF.

Hum Mol Genet. 2017 Oct 1;26(19):3763-3775. doi: 10.1093/hmg/ddx260.

PMID:
28934390
6.

Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective.

Baias M, Smith PE, Shen K, Joachimiak LA, Żerko S, Koźmiński W, Frydman J, Frydman L.

J Am Chem Soc. 2017 Jan 25;139(3):1168-1176. doi: 10.1021/jacs.6b10893. Epub 2017 Jan 13.

PMID:
28085263
7.

Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core.

Lin HK, Boatz JC, Krabbendam IE, Kodali R, Hou Z, Wetzel R, Dolga AM, Poirier MA, van der Wel PCA.

Nat Commun. 2017 May 24;8:15462. doi: 10.1038/ncomms15462.

8.

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation.

Peskett TR, Rau F, O'Driscoll J, Patani R, Lowe AR, Saibil HR.

Mol Cell. 2018 May 17;70(4):588-601.e6. doi: 10.1016/j.molcel.2018.04.007. Epub 2018 May 10.

9.

Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths.

Warner JB 4th, Ruff KM, Tan PS, Lemke EA, Pappu RV, Lashuel HA.

J Am Chem Soc. 2017 Oct 18;139(41):14456-14469. doi: 10.1021/jacs.7b06659. Epub 2017 Oct 9.

10.

Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding.

Chaibva M, Jawahery S, Pilkington AW 4th, Arndt JR, Sarver O, Valentine S, Matysiak S, Legleiter J.

Biophys J. 2016 Jul 26;111(2):349-362. doi: 10.1016/j.bpj.2016.06.018.

11.

Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways.

Moily NS, Ormsby AR, Stojilovic A, Ramdzan YM, Diesch J, Hannan RD, Zajac MS, Hannan AJ, Oshlack A, Hatters DM.

Mol Cell Neurosci. 2017 Sep;83:103-112. doi: 10.1016/j.mcn.2017.07.004. Epub 2017 Jul 23.

PMID:
28743452
12.

Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation.

Crick SL, Ruff KM, Garai K, Frieden C, Pappu RV.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20075-80. doi: 10.1073/pnas.1320626110. Epub 2013 Nov 26.

13.

Wild type huntingtin toxicity in yeast: Implications for the role of amyloid cross-seeding in polyQ diseases.

Alexandrov AI, Serpionov GV, Kushnirov VV, Ter-Avanesyan MD.

Prion. 2016 May 3;10(3):221-7. doi: 10.1080/19336896.2016.1176659.

14.

Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils.

Isas JM, Langen A, Isas MC, Pandey NK, Siemer AB.

Biochemistry. 2017 Jul 18;56(28):3579-3586. doi: 10.1021/acs.biochem.7b00138. Epub 2017 Jul 7.

15.

The emerging role of the first 17 amino acids of huntingtin in Huntington's disease.

Arndt JR, Chaibva M, Legleiter J.

Biomol Concepts. 2015 Mar;6(1):33-46. doi: 10.1515/bmc-2015-0001. Review.

16.

Polyglutamine tracts regulate beclin 1-dependent autophagy.

Ashkenazi A, Bento CF, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, Squitieri F, Hardenberg MC, Imarisio S, Menzies FM, Rubinsztein DC.

Nature. 2017 May 4;545(7652):108-111. doi: 10.1038/nature22078. Epub 2017 Apr 26.

17.

Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments.

Jayaraman M, Kodali R, Sahoo B, Thakur AK, Mayasundari A, Mishra R, Peterson CB, Wetzel R.

J Mol Biol. 2012 Feb 3;415(5):881-99. doi: 10.1016/j.jmb.2011.12.010. Epub 2011 Dec 9.

18.

Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences.

Lakhani VV, Ding F, Dokholyan NV.

PLoS Comput Biol. 2010 Apr 29;6(4):e1000772. doi: 10.1371/journal.pcbi.1000772.

19.

N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion.

Chen MZ, Mok SA, Ormsby AR, Muchowski PJ, Hatters DM.

J Huntingtons Dis. 2017;6(1):79-91. doi: 10.3233/JHD-160207.

PMID:
28339398
20.

The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract.

Bravo-Arredondo JM, Kegulian NC, Schmidt T, Pandey NK, Situ AJ, Ulmer TS, Langen R.

J Biol Chem. 2018 Dec 21;293(51):19613-19623. doi: 10.1074/jbc.RA118.004808. Epub 2018 Oct 12.

PMID:
30315108

Supplemental Content

Support Center